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Loss of Chromosome 9q

MedGen UID:
309331
Concept ID:
C1517995
Cell or Molecular Dysfunction
Synonym: del(9q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 9 (9q). It is associated with the development of acute myeloid leukemia and various types of carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 9q

Professional guidelines

PubMed

Huh J, Jung CW, Kim JW, Kim HJ, Kim SH, Shin MG, Kim YK, Kim HJ, Suh JS, Moon JH, Sohn SK, Nam GH, Lee JE, Kim DH
Ann Hematol 2011 Nov;90(11):1255-64. Epub 2011 Mar 8 doi: 10.1007/s00277-011-1195-2. PMID: 21384125
LeBron C, Pal P, Brait M, Dasgupta S, Guerrero-Preston R, Looijenga LH, Kowalski J, Netto G, Hoque MO
Genomics 2011 Jun;97(6):341-9. Epub 2011 Mar 2 doi: 10.1016/j.ygeno.2011.02.011. PMID: 21376111
Alers JC, Krijtenburg PJ, Vis AN, Hoedemaeker RF, Wildhagen MF, Hop WC, van Der Kwast TT, Schröder FH, Tanke HJ, van Dekken H
Am J Pathol 2001 Feb;158(2):399-406. doi: 10.1016/s0002-9440(10)63983-1. PMID: 11159178Free PMC Article

Recent clinical studies

Etiology

Kulkarni NV, Shetty VV, Prasad Hl K, Arumugam M, Krishna R, Shetty RA, Kalal AA, Shetty DP
Pol J Pathol 2023;74(2):89-97. doi: 10.5114/pjp.2023.129425. PMID: 37728468
Ambele MA, Robinson L, van Heerden MB, Pepper MS, van Heerden WFP
Mod Pathol 2023 Jan;36(1):100002. doi: 10.1016/j.modpat.2022.100002. PMID: 36788060
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365
Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J
Curr Probl Cancer 1997 Sep-Oct;21(5):233-300. doi: 10.1016/s0147-0272(97)80003-7. PMID: 9438104

Diagnosis

Kulkarni NV, Shetty VV, Prasad Hl K, Arumugam M, Krishna R, Shetty RA, Kalal AA, Shetty DP
Pol J Pathol 2023;74(2):89-97. doi: 10.5114/pjp.2023.129425. PMID: 37728468
Ambele MA, Robinson L, van Heerden MB, Pepper MS, van Heerden WFP
Mod Pathol 2023 Jan;36(1):100002. doi: 10.1016/j.modpat.2022.100002. PMID: 36788060
Waszak SM, Robinson GW, Gudenas BL, Smith KS, Forget A, Kojic M, Garcia-Lopez J, Hadley J, Hamilton KV, Indersie E, Buchhalter I, Kerssemakers J, Jäger N, Sharma T, Rausch T, Kool M, Sturm D, Jones DTW, Vasilyeva A, Tatevossian RG, Neale G, Lombard B, Loew D, Nakitandwe J, Rusch M, Bowers DC, Bendel A, Partap S, Chintagumpala M, Crawford J, Gottardo NG, Smith A, Dufour C, Rutkowski S, Eggen T, Wesenberg F, Kjaerheim K, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Remke M, Puget S, Pajtler KW, Milde T, Witt O, Ryzhova M, Korshunov A, Orr BA, Ellison DW, Brugieres L, Lichter P, Nichols KE, Gajjar A, Wainwright BJ, Ayrault O, Korbel JO, Northcott PA, Pfister SM
Nature 2020 Apr;580(7803):396-401. Epub 2020 Apr 1 doi: 10.1038/s41586-020-2164-5. PMID: 32296180Free PMC Article
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Castillo-Martin M, Domingo-Domenech J, Karni-Schmidt O, Matos T, Cordon-Cardo C
Urol Oncol 2010 Jul-Aug;28(4):401-8. doi: 10.1016/j.urolonc.2009.04.019. PMID: 20610278

Therapy

Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
van Tilborg AA, de Vries A, de Bont M, Groenfeld LE, Zwarthoff EC
J Pathol 2002 Nov;198(3):352-8. doi: 10.1002/path.1215. PMID: 12375268
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365
Hoogerwerf WA, Hawkins AL, Perlman EJ, Griffin CA
Genes Chromosomes Cancer 1994 Feb;9(2):88-92. doi: 10.1002/gcc.2870090203. PMID: 7513549
Sidransky D, Frost P, Von Eschenbach A, Oyasu R, Preisinger AC, Vogelstein B
N Engl J Med 1992 Mar 12;326(11):737-40. doi: 10.1056/NEJM199203123261104. PMID: 1445507

Prognosis

Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Kuroki T, Tajima Y, Matsuo K, Kanematsu T
Surg Today 2005;35(2):101-5. doi: 10.1007/s00595-004-2906-2. PMID: 15674488
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365
Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J
Curr Probl Cancer 1997 Sep-Oct;21(5):233-300. doi: 10.1016/s0147-0272(97)80003-7. PMID: 9438104
Pollak C, Hagemeijer A
Leukemia 1987 Jul;1(7):541-8. PMID: 3312844

Clinical prediction guides

Ambele MA, Robinson L, van Heerden MB, Pepper MS, van Heerden WFP
Mod Pathol 2023 Jan;36(1):100002. doi: 10.1016/j.modpat.2022.100002. PMID: 36788060
Gollin SM
Head Neck 2001 Mar;23(3):238-53. doi: 10.1002/1097-0347(200103)23:3<238::aid-hed1025>3.0.co;2-h. PMID: 11428456
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365
Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J
Curr Probl Cancer 1997 Sep-Oct;21(5):233-300. doi: 10.1016/s0147-0272(97)80003-7. PMID: 9438104
Saran KK, Gould D, Godec CJ, Verma RS
J Mol Med (Berl) 1996 Aug;74(8):441-5. doi: 10.1007/BF00217519. PMID: 8872857

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