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Malignant ovarian serous tumor

MedGen UID:
309396
•Concept ID:
C1518234
•
Neoplastic Process
Synonyms: Malignant Ovarian Serous Tumor; malignant ovarian serous tumor; ovarian serous tumor, malignant
 
Monarch Initiative: MONDO:0024885

Definition

An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. It includes serous adenocarcinoma and serous adenocarcinofibroma. [from NCI]

Professional guidelines

PubMed

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698

Recent clinical studies

Etiology

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints.
Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C
Int J Mol Sci 2019 Feb 22;20(4) doi: 10.3390/ijms20040952. PMID: 30813239Free PMC Article
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Giant Ovarian Tumor.
Kluz T, Bogaczyk A, Wita-Popów B, Habało P, Kluz-Barłowska M
Medicina (Kaunas) 2023 Oct 15;59(10) doi: 10.3390/medicina59101833. PMID: 37893550Free PMC Article
Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Rare ovarian tumors: an update on diagnosis and treatment.
Debuquoy C, Romeo C, Vanacker H, Ray-Coquard I
Int J Gynecol Cancer 2020 Jun;30(6):879-887. Epub 2020 May 26 doi: 10.1136/ijgc-2020-001235. PMID: 32461259
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Therapy

Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation.
Kandalaft LE, Dangaj Laniti D, Coukos G
Nat Rev Cancer 2022 Nov;22(11):640-656. Epub 2022 Sep 15 doi: 10.1038/s41568-022-00503-z. PMID: 36109621
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.
Konstantinopoulos PA, Ceccaldi R, Shapiro GI, D'Andrea AD
Cancer Discov 2015 Nov;5(11):1137-54. Epub 2015 Oct 13 doi: 10.1158/2159-8290.CD-15-0714. PMID: 26463832Free PMC Article

Prognosis

Spatial heterogeneity of infiltrating T cells in high-grade serous ovarian cancer revealed by multi-omics analysis.
Yang B, Li X, Zhang W, Fan J, Zhou Y, Li W, Yin J, Yang X, Guo E, Li X, Fu Y, Liu S, Hu D, Qin X, Dou Y, Xiao R, Lu F, Wang Z, Qin T, Wang W, Zhang Q, Li S, Ma D, Mills GB, Chen G, Sun C
Cell Rep Med 2022 Dec 20;3(12):100856. doi: 10.1016/j.xcrm.2022.100856. PMID: 36543113Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Prognostic indicators in ovarian serous borderline tumours.
Malpica A, Longacre TA
Pathology 2018 Feb;50(2):205-213. Epub 2017 Dec 28 doi: 10.1016/j.pathol.2017.12.001. PMID: 29289348
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307

Clinical prediction guides

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Whence High-Grade Serous Ovarian Cancer.
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Recent systematic reviews

Bevacizumab Treatment for Low-Grade Serous Ovarian Cancer: A Systematic Review.
Lazurko C, Linder R, Pulman K, Lennox G, Feigenberg T, Fazelzad R, May T, Zigras T
Curr Oncol 2023 Sep 3;30(9):8159-8171. doi: 10.3390/curroncol30090592. PMID: 37754507Free PMC Article
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.
Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, Chang DK, Garsed DW, Jonkers J, Ledermann JA, Nik-Zainal S, Ray-Coquard I, Shah SP, Matias-Guiu X, Swisher EM, Yates LR
Ann Oncol 2020 Dec;31(12):1606-1622. Epub 2020 Sep 28 doi: 10.1016/j.annonc.2020.08.2102. PMID: 33004253
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Perineal Talc Use and Ovarian Cancer: A Systematic Review and Meta-Analysis.
Penninkilampi R, Eslick GD
Epidemiology 2018 Jan;29(1):41-49. doi: 10.1097/EDE.0000000000000745. PMID: 28863045
Systematic review: Tumor-associated antigen autoantibodies and ovarian cancer early detection.
Fortner RT, Damms-Machado A, Kaaks R
Gynecol Oncol 2017 Nov;147(2):465-480. Epub 2017 Aug 8 doi: 10.1016/j.ygyno.2017.07.138. PMID: 28800944

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