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Malignant ovarian serous tumor

MedGen UID:
309396
Concept ID:
C1518234
Neoplastic Process
Synonyms: Malignant Ovarian Serous Tumor; malignant ovarian serous tumor; ovarian serous tumor, malignant
 
Monarch Initiative: MONDO:0024885

Definition

An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. It includes serous adenocarcinoma and serous adenocarcinofibroma. [from NCI]

Professional guidelines

PubMed

Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Recent clinical studies

Etiology

Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C
Int J Mol Sci 2019 Feb 22;20(4) doi: 10.3390/ijms20040952. PMID: 30813239Free PMC Article
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Debuquoy C, Romeo C, Vanacker H, Ray-Coquard I
Int J Gynecol Cancer 2020 Jun;30(6):879-887. Epub 2020 May 26 doi: 10.1136/ijgc-2020-001235. PMID: 32461259
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Therapy

Kandalaft LE, Dangaj Laniti D, Coukos G
Nat Rev Cancer 2022 Nov;22(11):640-656. Epub 2022 Sep 15 doi: 10.1038/s41568-022-00503-z. PMID: 36109621
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
Konstantinopoulos PA, Ceccaldi R, Shapiro GI, D'Andrea AD
Cancer Discov 2015 Nov;5(11):1137-54. Epub 2015 Oct 13 doi: 10.1158/2159-8290.CD-15-0714. PMID: 26463832Free PMC Article

Prognosis

Yang B, Li X, Zhang W, Fan J, Zhou Y, Li W, Yin J, Yang X, Guo E, Li X, Fu Y, Liu S, Hu D, Qin X, Dou Y, Xiao R, Lu F, Wang Z, Qin T, Wang W, Zhang Q, Li S, Ma D, Mills GB, Chen G, Sun C
Cell Rep Med 2022 Dec 20;3(12):100856. doi: 10.1016/j.xcrm.2022.100856. PMID: 36543113Free PMC Article
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Malpica A, Longacre TA
Pathology 2018 Feb;50(2):205-213. Epub 2017 Dec 28 doi: 10.1016/j.pathol.2017.12.001. PMID: 29289348
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073

Clinical prediction guides

Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480
Gloss BS, Samimi G
Cancer Lett 2014 Jan 28;342(2):257-63. Epub 2012 Jan 12 doi: 10.1016/j.canlet.2011.12.036. PMID: 22245949

Recent systematic reviews

Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, Chang DK, Garsed DW, Jonkers J, Ledermann JA, Nik-Zainal S, Ray-Coquard I, Shah SP, Matias-Guiu X, Swisher EM, Yates LR
Ann Oncol 2020 Dec;31(12):1606-1622. Epub 2020 Sep 28 doi: 10.1016/j.annonc.2020.08.2102. PMID: 33004253
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Abu Hassaan SO
Dan Med J 2018 Apr;65(4) PMID: 29619933
Fortner RT, Damms-Machado A, Kaaks R
Gynecol Oncol 2017 Nov;147(2):465-480. Epub 2017 Aug 8 doi: 10.1016/j.ygyno.2017.07.138. PMID: 28800944

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