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Columnar cell hyperplasia of the breast

MedGen UID:
310623
Concept ID:
C1707446
Neoplastic Process
Synonyms: Breast Columnar Cell Hyperplasia; CCH; Columnar Cell Hyperplasia of Breast; columnar cell hyperplasia of breast; Columnar Cell Hyperplasia of the Breast; columnar cell hyperplasia of the breast
 
Monarch Initiative: MONDO:0006166

Definition

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini. The acini are lined by more than two layers of columnar epithelial cells. Prominent apical cytoplasmic snouts are present. Secretions are often present in the lumina of the dilated acini. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColumnar cell hyperplasia of the breast

Recent clinical studies

Etiology

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Verschuur-Maes AH, Witkamp AJ, de Bruin PC, van der Wall E, van Diest PJ
Int J Cancer 2011 Dec 1;129(11):2674-80. Epub 2011 Mar 25 doi: 10.1002/ijc.25926. PMID: 21225627
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Diagnosis

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Verschuur-Maes AH, Witkamp AJ, de Bruin PC, van der Wall E, van Diest PJ
Int J Cancer 2011 Dec 1;129(11):2674-80. Epub 2011 Mar 25 doi: 10.1002/ijc.25926. PMID: 21225627
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736
Schnitt SJ, Vincent-Salomon A
Adv Anat Pathol 2003 May;10(3):113-24. doi: 10.1097/00125480-200305000-00001. PMID: 12717115

Therapy

Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Garijo MF, Val-Bernal JF, Vega A, Val D
Pathol Int 2008 Dec;58(12):787-91. doi: 10.1111/j.1440-1827.2008.02312.x. PMID: 19067854

Prognosis

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Gomes DS, Porto SS, Balabram D, Gobbi H
Diagn Pathol 2014 Jun 19;9:121. doi: 10.1186/1746-1596-9-121. PMID: 24948027Free PMC Article
Verschuur-Maes AH, Witkamp AJ, de Bruin PC, van der Wall E, van Diest PJ
Int J Cancer 2011 Dec 1;129(11):2674-80. Epub 2011 Mar 25 doi: 10.1002/ijc.25926. PMID: 21225627

Clinical prediction guides

Samples LS, Rendi MH, Frederick PD, Allison KH, Nelson HD, Morgan TR, Weaver DL, Elmore JG
Breast 2017 Aug;34:34-43. Epub 2017 May 3 doi: 10.1016/j.breast.2017.04.004. PMID: 28475933Free PMC Article
Picouleau E, Denis M, Lavoue V, Tas P, Mesbah H, Poree P, Leveque J, Morcel K
Anticancer Res 2012 Dec;32(12):5441-6. PMID: 23225449
O'Malley FP, Mohsin SK, Badve S, Bose S, Collins LC, Ennis M, Kleer CG, Pinder SE, Schnitt SJ
Mod Pathol 2006 Feb;19(2):172-9. doi: 10.1038/modpathol.3800514. PMID: 16424892
Tan PH, Ho BC, Selvarajan S, Yap WM, Hanby A
J Clin Pathol 2005 Jul;58(7):705-9. doi: 10.1136/jcp.2004.025239. PMID: 15976336Free PMC Article
Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037Free PMC Article

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