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Columnar cell hyperplasia of the breast

MedGen UID:
310623
•Concept ID:
C1707446
•
Neoplastic Process
Synonyms: Breast Columnar Cell Hyperplasia; CCH; Columnar Cell Hyperplasia of Breast; columnar cell hyperplasia of breast; Columnar Cell Hyperplasia of the Breast; columnar cell hyperplasia of the breast
 
Monarch Initiative: MONDO:0006166

Definition

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini. The acini are lined by more than two layers of columnar epithelial cells. Prominent apical cytoplasmic snouts are present. Secretions are often present in the lumina of the dilated acini. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColumnar cell hyperplasia of the breast

Professional guidelines

PubMed

Pre-operative diagnosis of breast cancer in screening: problems and pitfalls.
Provenzano E, Pinder SE
Pathology 2009 Jan;41(1):3-17. doi: 10.1080/00313020802563478. PMID: 19089735
Criteria for the diagnosis of fibroepithelial lesions of the breast with liquid-based cytology.
Ali AS, Yin D, Yao D, Vazquez M
Acta Cytol 2004 Jul-Aug;48(4):481-6. doi: 10.1159/000326408. PMID: 15296337
The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.
Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037Free PMC Article

Recent clinical studies

Etiology

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Atypical epithelial hyperplasia of the breast: state of the art.
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Flat epithelial atypia of the breast: characteristics and behaviors.
Sudarshan M, Meguerditchian AN, Mesurolle B, Meterissian S
Am J Surg 2011 Feb;201(2):245-50. Epub 2010 Sep 22 doi: 10.1016/j.amjsurg.2010.02.009. PMID: 20864078
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Diagnosis

Challenges and Clinical Relevance of Modern Breast Pathology Reporting: Your Questions Answered.
Deb R, Laokulrath N, Chagla L, Tan PH
Pathobiology 2024;91(4):299-312. Epub 2024 Feb 8 doi: 10.1159/000536638. PMID: 38330933
Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Atypical epithelial hyperplasia of the breast: state of the art.
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736
Columnar cell lesions of the breast.
Schnitt SJ, Vincent-Salomon A
Adv Anat Pathol 2003 May;10(3):113-24. doi: 10.1097/00125480-200305000-00001. PMID: 12717115

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Postoperative spindle cell nodule of the breast: Pseudosarcomatous myofibroblastic proliferation following endo-surgery.
Garijo MF, Val-Bernal JF, Vega A, Val D
Pathol Int 2008 Dec;58(12):787-91. doi: 10.1111/j.1440-1827.2008.02312.x. PMID: 19067854

Prognosis

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast.
Gomes DS, Porto SS, Balabram D, Gobbi H
Diagn Pathol 2014 Jun 19;9:121. doi: 10.1186/1746-1596-9-121. PMID: 24948027Free PMC Article
Progression risk of columnar cell lesions of the breast diagnosed in core needle biopsies.
Verschuur-Maes AH, Witkamp AJ, de Bruin PC, van der Wall E, van Diest PJ
Int J Cancer 2011 Dec 1;129(11):2674-80. Epub 2011 Mar 25 doi: 10.1002/ijc.25926. PMID: 21225627

Clinical prediction guides

Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens.
Samples LS, Rendi MH, Frederick PD, Allison KH, Nelson HD, Morgan TR, Weaver DL, Elmore JG
Breast 2017 Aug;34:34-43. Epub 2017 May 3 doi: 10.1016/j.breast.2017.04.004. PMID: 28475933Free PMC Article
Atypical hyperplasia of the breast: the black hole of routine breast cancer screening.
Picouleau E, Denis M, Lavoue V, Tas P, Mesbah H, Poree P, Leveque J, Morcel K
Anticancer Res 2012 Dec;32(12):5441-6. PMID: 23225449
Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast.
O'Malley FP, Mohsin SK, Badve S, Bose S, Collins LC, Ennis M, Kleer CG, Pinder SE, Schnitt SJ
Mod Pathol 2006 Feb;19(2):172-9. doi: 10.1038/modpathol.3800514. PMID: 16424892
Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?
Tan PH, Ho BC, Selvarajan S, Yap WM, Hanby A
J Clin Pathol 2005 Jul;58(7):705-9. doi: 10.1136/jcp.2004.025239. PMID: 15976336Free PMC Article
The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.
Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037Free PMC Article

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