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Breast Columnar Cell Lesion

MedGen UID:
317529
•Concept ID:
C1707448
•
Neoplastic Process
Synonyms: Columnar Cell Lesion of Breast; Columnar Cell Lesion of the Breast

Definition

A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma. These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units. Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ. Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known. [from NCI]

Professional guidelines

PubMed

Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.
Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037Free PMC Article

Recent clinical studies

Etiology

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Precursor Lesions of the Low-Grade Breast Neoplasia Pathway.
Collins LC
Surg Pathol Clin 2018 Mar;11(1):177-197. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.007. PMID: 29413656
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736
Columnar cell lesions of the breast.
Feeley L, Quinn CM
Histopathology 2008 Jan;52(1):11-9. doi: 10.1111/j.1365-2559.2007.02890.x. PMID: 18171413

Diagnosis

Papillomatous breast lesions with atypical columnar cell features.
de Boer M, Verschuur-Maes AHJ, Moelans C, van Diest PJ
J Clin Pathol 2023 Apr;76(4):228-233. Epub 2023 Jan 24 doi: 10.1136/jcp-2022-208389. PMID: 36693714
Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Blunt duct adenosis: a separate entity from columnar cell lesions?
de Boer M, van Diest PJ
J Clin Pathol 2022 Jan;75(1):5-9. Epub 2021 Apr 15 doi: 10.1136/jclinpath-2020-207359. PMID: 33858936Free PMC Article
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
HPV and cervical cancer.
Petry KU
Scand J Clin Lab Invest Suppl 2014;244:59-62; discussion 62. doi: 10.3109/00365513.2014.936683. PMID: 25083895
A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.
Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540Free PMC Article
Columnar cell lesions, mammographic density and breast cancer risk.
Turashvili G, McKinney S, Martin L, Gelmon KA, Watson P, Boyd N, Aparicio S
Breast Cancer Res Treat 2009 Jun;115(3):561-71. Epub 2008 Jun 28 doi: 10.1007/s10549-008-0099-x. PMID: 18587641

Prognosis

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Columnar cell-like changes in the male breast.
Ni YB, Mujtaba S, Shao MM, Lacambra M, Tsang JY, Chan SK, Tse GM
J Clin Pathol 2014 Jan;67(1):45-8. Epub 2013 Aug 6 doi: 10.1136/jclinpath-2013-201631. PMID: 23922357
Current issues in diagnostic breast pathology.
Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO; National Coordinating Committee for Breast Pathology Research Subgroup
J Clin Pathol 2012 Sep;65(9):771-85. Epub 2012 Jul 19 doi: 10.1136/jclinpath-2012-200733. PMID: 22813732

Clinical prediction guides

Nuclear morphology in breast lesions: refining its assessment to improve diagnostic concordance.
Katayama A, Toss MS, Parkin M, Sano T, Oyama T, Quinn CM, Ellis IO, Rakha EA
Histopathology 2022 Feb;80(3):515-528. Epub 2021 Dec 2 doi: 10.1111/his.14577. PMID: 34605058
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Current issues in diagnostic breast pathology.
Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO; National Coordinating Committee for Breast Pathology Research Subgroup
J Clin Pathol 2012 Sep;65(9):771-85. Epub 2012 Jul 19 doi: 10.1136/jclinpath-2012-200733. PMID: 22813732
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436
Non-operative breast pathology: columnar cell lesions.
Pinder SE, Reis-Filho JS
J Clin Pathol 2007 Dec;60(12):1307-12. Epub 2006 Dec 20 doi: 10.1136/jcp.2006.040634. PMID: 17182657Free PMC Article

Recent systematic reviews

Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review.
Verschuur-Maes AH, van Deurzen CH, Monninkhof EM, van Diest PJ
Ann Surg 2012 Feb;255(2):259-65. doi: 10.1097/SLA.0b013e318233523f. PMID: 21989373

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