Micronodular Thymoma with Lymphoid Stroma

MedGen UID:: 311007
•Concept ID:: C1709024
•: Neoplastic Process

Synonyms:	Micronodular Thymoma; Micronodular Thymoma with Lymphoid B-Cell Hyperplasia; Micronodular thymoma with lymphoid stroma
SNOMED CT:	Micronodular thymoma with lymphoid stroma (726423000)

Definition

A rare type of thymoma characterized by the presence of multiple, well formed epithelial nodules separated by a lymphocytic stroma that usually contains germinal centers. Reported cases have not been associated with recurrences or metastases. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMicronodular Thymoma with Lymphoid Stroma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Thymoma
        Micronodular Thymoma with Lymphoid Stroma

Recent clinical studies

Etiology

GTF2I mutation in micronodular thymoma with lymphoid stroma.

Bille A, Fryer K, Wallace A, Nonaka D
J Clin Pathol 2024 Jan 18;77(2):125-127. doi: 10.1136/jcp-2022-208655. PMID: 36600564

Clinicopathologic and prognostic factors of thymoma in Tunisia.

Braham E, Kilani T, El Mezni F
Tunis Med 2016 Feb;94(2):118-22. PMID: 27532527

See all (2)

Diagnosis

GTF2I mutation in micronodular thymoma with lymphoid stroma.

Bille A, Fryer K, Wallace A, Nonaka D
J Clin Pathol 2024 Jan 18;77(2):125-127. doi: 10.1136/jcp-2022-208655. PMID: 36600564

Constant p.L424H Mutation in GTF2I in Micronodular Thymomas With Lymphoid Stroma: Evidence Supporting Close Relationship With Type A and AB Thymomas.

Hsieh MS, Kao HL, Huang WC, Wang SY, Lin SY, Chu PY, Pan CC, Chou TY, Ho HL, Yeh YC
Mod Pathol 2023 Feb;36(2):100008. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100008. PMID: 36853782

Micronodular Thymoma with Lymphoid Stroma: A Case Report.

Tsuchiya T, Sano A, Kawashima M
Tokai J Exp Clin Med 2021 Jul 20;46(2):94-96. PMID: 34216482

Difference in the distribution of tumor-infiltrating CD8+ T cells and FOXP3+ T cells between micronodular thymoma with lymphoid stroma and micronodular thymic carcinoma with lymphoid stroma.

Yagi H, Nakaguro M, Ito M, Okumura Y, Takahashi S, Aoshima Y, Enomoto Y, Meguro S, Kawasaki H, Kosugi I, Shimoyama Y, Ogawa H, Tateyama H, Iwashita T
Pathol Int 2021 Jul;71(7):453-462. Epub 2021 Apr 5 doi: 10.1111/pin.13099. PMID: 33819365 Free PMC Article

Micronodular Thymoma With Lymphoid Stroma: A Trio of Cases, With Diverse-associated Histological Features.

Bakshi N, Dhawan S, Rao S, Singh Rawat K
Int J Surg Pathol 2021 Sep;29(6):693-697. Epub 2021 Mar 8 doi: 10.1177/10668969211001110. PMID: 33683925

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Prognosis

The clinicopathological significance of thymic epithelial markers expression in thymoma and thymic carcinoma.

Li H, Ren B, Yu S, Gao H, Sun PL
BMC Cancer 2023 Feb 16;23(1):161. doi: 10.1186/s12885-023-10619-6. PMID: 36797681 Free PMC Article

Micronodular Thymoma with Lymphoid Stroma: A Case Report.

Tsuchiya T, Sano A, Kawashima M
Tokai J Exp Clin Med 2021 Jul 20;46(2):94-96. PMID: 34216482

Micronodular Thymoma With Lymphoid Stroma: A Trio of Cases, With Diverse-associated Histological Features.

Bakshi N, Dhawan S, Rao S, Singh Rawat K
Int J Surg Pathol 2021 Sep;29(6):693-697. Epub 2021 Mar 8 doi: 10.1177/10668969211001110. PMID: 33683925

Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review.

Qu L, Xiong Y, Yao Q, Zhang B, Li T
Thorac Cancer 2017 Nov;8(6):734-740. Epub 2017 Sep 20 doi: 10.1111/1759-7714.12517. PMID: 28941195 Free PMC Article

Cystic thymoma.

Rieker RJ, Aulmann S, Schnabel PA, Sack FU, Otto HF, Mechtersheimer G, Schirmacher P, Bläker H
Pathol Oncol Res 2005;11(1):57-60. Epub 2005 Mar 31 doi: 10.1007/BF03032408. PMID: 15800684

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