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Vaginal Undifferentiated Carcinoma

MedGen UID:
311448
Concept ID:
C1519934
Neoplastic Process

Definition

A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Undifferentiated Carcinoma

Professional guidelines

PubMed

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

Rios-Doria E, Cun HT, Filippova OT, Mueller JJ, Alektiar KM, Ellenson LH, Makker V, Lakhman Y, Leitao MM Jr, Jhingran A, Soliman PT, Abu-Rustum NR
Gynecol Oncol 2023 Dec;179:9-15. Epub 2023 Oct 20 doi: 10.1016/j.ygyno.2023.10.011. PMID: 37864854Free PMC Article
Fuller AE, Dunsmoor-Su R
Curr Opin Obstet Gynecol 2023 Apr 1;35(2):164-168. doi: 10.1097/GCO.0000000000000847. PMID: 36924412
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Wortman BG, Creutzberg CL, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LCHW, van der Steen-Banasik EM, Mens JWM, Slot A, Kroese MCS, van Triest B, Nijman HW, Stelloo E, Bosse T, de Boer SM, van Putten WLJ, Smit VTHBM, Nout RA; PORTEC Study Group
Br J Cancer 2018 Oct;119(9):1067-1074. Epub 2018 Oct 25 doi: 10.1038/s41416-018-0310-8. PMID: 30356126Free PMC Article
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Diagnosis

Jhingran A
Int J Gynecol Cancer 2022 Mar;32(3):344-351. doi: 10.1136/ijgc-2021-002517. PMID: 35256422Free PMC Article
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Therapy

van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Randall ME, Filiaci V, McMeekin DS, von Gruenigen V, Huang H, Yashar CM, Mannel RS, Kim JW, Salani R, DiSilvestro PA, Burke JJ, Rutherford T, Spirtos NM, Terada K, Anderson PR, Brewster WR, Small W, Aghajanian CA, Miller DS
J Clin Oncol 2019 Jul 20;37(21):1810-1818. Epub 2019 Apr 17 doi: 10.1200/JCO.18.01575. PMID: 30995174Free PMC Article
Wortman BG, Creutzberg CL, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LCHW, van der Steen-Banasik EM, Mens JWM, Slot A, Kroese MCS, van Triest B, Nijman HW, Stelloo E, Bosse T, de Boer SM, van Putten WLJ, Smit VTHBM, Nout RA; PORTEC Study Group
Br J Cancer 2018 Oct;119(9):1067-1074. Epub 2018 Oct 25 doi: 10.1038/s41416-018-0310-8. PMID: 30356126Free PMC Article
Gurumurthy M, Cruickshank ME
J Low Genit Tract Dis 2012 Jul;16(3):306-12. doi: 10.1097/LGT.0b013e31823da7fb. PMID: 22460272
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Prognosis

Lorentzen GM, Łaniewski P, Cui H, Mahnert ND, Mourad J, Borst MP, Willmott L, Chase DM, Roe DJ, Herbst-Kralovetz MM
Clin Cancer Res 2024 Jul 15;30(14):3073-3087. doi: 10.1158/1078-0432.CCR-23-2934. PMID: 38687603Free PMC Article
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Testa AC, Di Legge A, De Blasis I, Moruzzi MC, Bonatti M, Collarino A, Rufini V, Manfredi R
Best Pract Res Clin Obstet Gynaecol 2014 Jul;28(5):741-68. Epub 2014 May 4 doi: 10.1016/j.bpobgyn.2014.04.009. PMID: 24861248
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Clinical prediction guides

Lorentzen GM, Łaniewski P, Cui H, Mahnert ND, Mourad J, Borst MP, Willmott L, Chase DM, Roe DJ, Herbst-Kralovetz MM
Clin Cancer Res 2024 Jul 15;30(14):3073-3087. doi: 10.1158/1078-0432.CCR-23-2934. PMID: 38687603Free PMC Article
Gomez Cherey JF, Payalef SN, Fleider L, Reyes AP, Maldonado VA, Losada MO, Chen X, Cardinal LH, Wang Y, Tatti SA, Perazzi BE
Int J Gynecol Cancer 2023 Apr 3;33(4):482-488. doi: 10.1136/ijgc-2022-003760. PMID: 36604120
Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S, Schlumbrecht MP
Cancer Res Commun 2022 Jun;2(6):447-455. Epub 2022 Jun 16 doi: 10.1158/2767-9764.CRC-22-0075. PMID: 35928983Free PMC Article
Bruyniks N, Biglia N, Palacios S, Mueck AO
Climacteric 2017 Jun;20(3):195-204. Epub 2017 Mar 7 doi: 10.1080/13697137.2017.1284780. PMID: 28267367
Mody DR
Cancer 1999 Oct 25;87(5):243-4. doi: 10.1002/(sici)1097-0142(19991025)87:5<243::aid-cncr1>3.0.co;2-5. PMID: 10536347

Recent systematic reviews

Simon JA, Ferenczy A, Black D, Castonguay A, Royer C, Marouf R, Beauchemin C
Menopause 2023 Aug 1;30(8):855-866. Epub 2023 Jun 27 doi: 10.1097/GME.0000000000002211. PMID: 37369079Free PMC Article
Frigerio M, Inzoli A, Barba M
Int J Gynaecol Obstet 2022 Nov;159(2):365-371. Epub 2022 Feb 28 doi: 10.1002/ijgo.14137. PMID: 35167139
Inayama Y, Yamanishi Y, Nakatani E, Aratake J, Sasagasako N, Yamada K, Gou R, Kawamura A, Yamanishi M, Kosaka K
Gynecol Oncol 2021 Jan;160(1):140-147. Epub 2020 Oct 1 doi: 10.1016/j.ygyno.2020.09.031. PMID: 33010966
Frias-Gomez J, Benavente Y, Ponce J, Brunet J, Ibáñez R, Peremiquel-Trillas P, Baixeras N, Zanca A, Piulats JM, Aytés Á, Matias-Guiu X, Bosch FX, de Sanjosé S, Alemany L, Costas L; Screenwide Team
Cancer Cytopathol 2020 Nov;128(11):792-802. Epub 2020 Mar 23 doi: 10.1002/cncy.22266. PMID: 32202704
Guerri S, Perrone AM, Buwenge M, Ferioli M, Macchia G, Tagliaferri L, Ferrandina G, Galuppi A, Andrulli AD, Frakulli R, Cammelli S, Arcelli A, De Iaco P, Morganti AG
Oncologist 2019 Jan;24(1):132-141. Epub 2018 Aug 23 doi: 10.1634/theoncologist.2017-0546. PMID: 30139838Free PMC Article

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