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FUS-ERG Fusion Protein Expression

MedGen UID:
313186
•Concept ID:
C1708030
•
Cell or Molecular Dysfunction
Synonym: FUS/ERG Fusion Protein Expression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFUS-ERG Fusion Protein Expression

Recent clinical studies

Etiology

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.
Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A
J Cancer Res Clin Oncol 2019 May;145(5):1273-1281. Epub 2019 Mar 20 doi: 10.1007/s00432-019-02895-2. PMID: 30895378Free PMC Article
Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients.
Chen X, Wang F, Zhang Y, Wang M, Tian W, Teng W, Ma X, Guo L, Fang J, Zhang Y, Zhu P, Liu H
Leuk Lymphoma 2019 Apr;60(4):1071-1078. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1516876. PMID: 30277115
Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group.
Noort S, Zimmermann M, Reinhardt D, Cuccuini W, Pigazzi M, Smith J, Ries RE, Alonzo TA, Hirsch B, Tomizawa D, Locatelli F, Gruber TA, Raimondi S, Sonneveld E, Cheuk DK, Dworzak M, Stary J, Abrahamsson J, Arad-Cohen N, Czogala M, De Moerloose B, Hasle H, Meshinchi S, van den Heuvel-Eibrink M, Zwaan CM
Blood 2018 Oct 11;132(15):1584-1592. Epub 2018 Aug 27 doi: 10.1182/blood-2018-05-849059. PMID: 30150206Free PMC Article
Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia.
Matsuo H, Iijima-Yamashita Y, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K
Pediatr Int 2018 Jan;60(1):41-46. doi: 10.1111/ped.13440. PMID: 29067751
Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).
Ichikawa H, Shimizu K, Katsu R, Ohki M
Mol Cell Biol 1999 Nov;19(11):7639-50. doi: 10.1128/MCB.19.11.7639. PMID: 10523652Free PMC Article

Diagnosis

Gene of the month: ERG.
Mullen D, Nowak K, Chetty R
J Clin Pathol 2022 Sep;75(9):577-580. Epub 2022 Jun 23 doi: 10.1136/jcp-2022-208350. PMID: 35738886
DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.
Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A
J Cancer Res Clin Oncol 2019 May;145(5):1273-1281. Epub 2019 Mar 20 doi: 10.1007/s00432-019-02895-2. PMID: 30895378Free PMC Article
Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients.
Chen X, Wang F, Zhang Y, Wang M, Tian W, Teng W, Ma X, Guo L, Fang J, Zhang Y, Zhu P, Liu H
Leuk Lymphoma 2019 Apr;60(4):1071-1078. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1516876. PMID: 30277115
Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia.
Matsuo H, Iijima-Yamashita Y, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K
Pediatr Int 2018 Jan;60(1):41-46. doi: 10.1111/ped.13440. PMID: 29067751
CD56 antigen expression and hemophagocytosis of leukemic cells in acute myeloid leukemia with t(16;21)(p11;q22).
Jekarl DW, Kim M, Lim J, Kim Y, Han K, Lee AW, Kim HJ, Min WS
Int J Hematol 2010 Sep;92(2):306-13. Epub 2010 Aug 10 doi: 10.1007/s12185-010-0650-5. PMID: 20694842

Therapy

ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.
Magistroni V, Mologni L, Sanselicio S, Reid JF, Redaelli S, Piazza R, Viltadi M, Bovo G, Strada G, Grasso M, Gariboldi M, Gambacorti-Passerini C
PLoS One 2011;6(11):e28162. Epub 2011 Nov 30 doi: 10.1371/journal.pone.0028162. PMID: 22140532Free PMC Article
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y
Blood 1997 Aug 1;90(3):1192-9. PMID: 9242552

Prognosis

Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group.
Noort S, Zimmermann M, Reinhardt D, Cuccuini W, Pigazzi M, Smith J, Ries RE, Alonzo TA, Hirsch B, Tomizawa D, Locatelli F, Gruber TA, Raimondi S, Sonneveld E, Cheuk DK, Dworzak M, Stary J, Abrahamsson J, Arad-Cohen N, Czogala M, De Moerloose B, Hasle H, Meshinchi S, van den Heuvel-Eibrink M, Zwaan CM
Blood 2018 Oct 11;132(15):1584-1592. Epub 2018 Aug 27 doi: 10.1182/blood-2018-05-849059. PMID: 30150206Free PMC Article
Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia.
Matsuo H, Iijima-Yamashita Y, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K
Pediatr Int 2018 Jan;60(1):41-46. doi: 10.1111/ped.13440. PMID: 29067751
Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia.
Liu F, Gao L, Jing Y, Xu YY, Ding Y, Zhou MH, Ma C, Li MY, Sun JZ, Wang LL, Yu L
Leuk Lymphoma 2013 Jul;54(7):1521-6. Epub 2013 Jan 7 doi: 10.3109/10428194.2012.754888. PMID: 23210573
CD56 antigen expression and hemophagocytosis of leukemic cells in acute myeloid leukemia with t(16;21)(p11;q22).
Jekarl DW, Kim M, Lim J, Kim Y, Han K, Lee AW, Kim HJ, Min WS
Int J Hematol 2010 Sep;92(2):306-13. Epub 2010 Aug 10 doi: 10.1007/s12185-010-0650-5. PMID: 20694842
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y
Blood 1997 Aug 1;90(3):1192-9. PMID: 9242552

Clinical prediction guides

Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia.
Matsuo H, Iijima-Yamashita Y, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K
Pediatr Int 2018 Jan;60(1):41-46. doi: 10.1111/ped.13440. PMID: 29067751
Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias.
Yi H, Fujimura Y, Ouchida M, Prasad DD, Rao VN, Reddy ES
Oncogene 1997 Mar 20;14(11):1259-68. doi: 10.1038/sj.onc.1201099. PMID: 9178886

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