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Inhibition of Amyloidogenesis

MedGen UID:
313308
•Concept ID:
C1708512
•
Molecular Function

Definition

Inhibition of Amyloidogenesis is a process that prevents the formation or growth of amyloid structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInhibition of Amyloidogenesis

Professional guidelines

PubMed

The antidepressant drug; trazodone inhibits Tau amyloidogenesis: Prospects for prophylaxis and treatment of AD.
Akbari V, Ghobadi S, Mohammadi S, Khodarahmi R
Arch Biochem Biophys 2020 Jan 15;679:108218. Epub 2019 Dec 2 doi: 10.1016/j.abb.2019.108218. PMID: 31805267
Current strategies for the treatment of Alzheimer's disease and other tauopathies.
Dickey CA, Petrucelli L
Expert Opin Ther Targets 2006 Oct;10(5):665-76. doi: 10.1517/14728222.10.5.665. PMID: 16981824
Pathogenesis, diagnosis and treatment of systemic amyloidosis.
Pepys MB
Philos Trans R Soc Lond B Biol Sci 2001 Feb 28;356(1406):203-10; discussion 210-1. doi: 10.1098/rstb.2000.0766. PMID: 11260801Free PMC Article

Recent clinical studies

Etiology

Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature.
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Kitakami R, Inui K, Nakagawa Y, Sawai Y, Katayama W, Yokoyama T, Okada T, Kanamitsu K, Nakagawa S, Toyooka N, Mizuguchi M
Bioorg Med Chem 2021 Aug 15;44:116292. Epub 2021 Jun 26 doi: 10.1016/j.bmc.2021.116292. PMID: 34225167
Sequence and structure-based peptides as potent amyloid inhibitors: A review.
Mitra A, Sarkar N
Arch Biochem Biophys 2020 Nov 30;695:108614. Epub 2020 Sep 30 doi: 10.1016/j.abb.2020.108614. PMID: 33010227
α-Synuclein chaperone suppresses nucleation and amyloidogenesis of prion protein.
Shirasaka M, Kuwata K, Honda R
Biochem Biophys Res Commun 2020 Jan 1;521(1):259-264. Epub 2019 Oct 18 doi: 10.1016/j.bbrc.2019.10.120. PMID: 31635805
Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1.
Mompeán M, Ramírez de Mingo D, Hervás R, Fernández-Ramírez MDC, Carrión-Vázquez M, Laurents DV
Arch Biochem Biophys 2019 Oct 30;675:108113. Epub 2019 Sep 27 doi: 10.1016/j.abb.2019.108113. PMID: 31568752

Diagnosis

Dual Role of a Fluorescent Small Molecule as a Sensor and Inhibitor of Protein Fibrillation.
Das A, Sah P, Saraogi I
Chem Asian J 2023 Feb 14;18(4):e202201309. Epub 2023 Jan 18 doi: 10.1002/asia.202201309. PMID: 36594929
Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics.
Gandhi J, Antonelli AC, Afridi A, Vatsia S, Joshi G, Romanov V, Murray IVJ, Khan SA
Rev Neurosci 2019 May 27;30(4):339-358. doi: 10.1515/revneuro-2016-0035. PMID: 30742586
The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity.
Bi TM, Daggett V
Yale J Biol Med 2018 Sep;91(3):247-255. Epub 2018 Sep 21 PMID: 30258312Free PMC Article
Modulating the Amyloidogenesis of α-Synuclein.
Sivanesam K, Andersen NH
Curr Neuropharmacol 2016;14(3):226-37. doi: 10.2174/1570159x13666151030103153. PMID: 26517049Free PMC Article
Pathogenesis, diagnosis and treatment of systemic amyloidosis.
Pepys MB
Philos Trans R Soc Lond B Biol Sci 2001 Feb 28;356(1406):203-10; discussion 210-1. doi: 10.1098/rstb.2000.0766. PMID: 11260801Free PMC Article

Therapy

Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature.
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Kitakami R, Inui K, Nakagawa Y, Sawai Y, Katayama W, Yokoyama T, Okada T, Kanamitsu K, Nakagawa S, Toyooka N, Mizuguchi M
Bioorg Med Chem 2021 Aug 15;44:116292. Epub 2021 Jun 26 doi: 10.1016/j.bmc.2021.116292. PMID: 34225167
Sequence and structure-based peptides as potent amyloid inhibitors: A review.
Mitra A, Sarkar N
Arch Biochem Biophys 2020 Nov 30;695:108614. Epub 2020 Sep 30 doi: 10.1016/j.abb.2020.108614. PMID: 33010227
Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases.
Moradi Majd R, Mayeli M, Rahmani F
Metab Brain Dis 2020 Dec;35(8):1241-1250. Epub 2020 Jul 17 doi: 10.1007/s11011-020-00600-8. PMID: 32681467
Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.
Yokoyama T, Mizuguchi M
Biol Pharm Bull 2018;41(7):979-984. doi: 10.1248/bpb.b18-00166. PMID: 29962408

Prognosis

Identification of novel amyloidosis in dogs: α-S1-casein acquires amyloidogenicity in mammary tumor by overexpression and N-terminal truncation.
Murakami T, Kaku T, Tsukakoshi K, Iwaide S, Itoh Y, Hisada M, Nomura K, Kubo R, Ikebukuro K, Sassa-O'Brien Y, Kametani F
Vet Pathol 2023 Mar;60(2):203-213. Epub 2023 Jan 21 doi: 10.1177/03009858221148511. PMID: 36680468
Is It Possible to Create Antimicrobial Peptides Based on the Amyloidogenic Sequence of Ribosomal S1 Protein of P. aeruginosa?
Grishin SY, Domnin PA, Kravchenko SV, Azev VN, Mustaeva LG, Gorbunova EY, Kobyakova MI, Surin AK, Makarova MA, Kurpe SR, Fadeev RS, Vasilchenko AS, Firstova VV, Ermolaeva SA, Galzitskaya OV
Int J Mol Sci 2021 Sep 10;22(18) doi: 10.3390/ijms22189776. PMID: 34575940Free PMC Article
A novel phytochemical from Dipteris wallichii inhibits human β-secretase 1: Implications for the treatment of Alzheimer's disease.
Chetia P, Mazumder MK, Mahanta S, De B, Dutta Choudhury M
Med Hypotheses 2020 Oct;143:109839. Epub 2020 May 18 doi: 10.1016/j.mehy.2020.109839. PMID: 32473508
The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity.
Bi TM, Daggett V
Yale J Biol Med 2018 Sep;91(3):247-255. Epub 2018 Sep 21 PMID: 30258312Free PMC Article
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW
J Am Chem Soc 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. PMID: 20043671Free PMC Article

Clinical prediction guides

Synthesis and biological evaluation of quinolone derivatives as transthyretin amyloidogenesis inhibitors and fluorescence sensors.
Reum Han A, Hee Jeon E, Woo Kim K, Ki Lee S, Ohn CY, Jean Park S, Sook Kang N, Koo TS, Bum Hong K, Choi S
Bioorg Med Chem 2022 Jan 1;53:116550. Epub 2021 Dec 4 doi: 10.1016/j.bmc.2021.116550. PMID: 34890995
In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis.
Bezerra F, Niemietz C, Schmidt HHJ, Zibert A, Guo S, Monia BP, Gonçalves P, Saraiva MJ, Almeida MR
Int J Mol Sci 2021 Aug 31;22(17) doi: 10.3390/ijms22179488. PMID: 34502397Free PMC Article
Sequence and structure-based peptides as potent amyloid inhibitors: A review.
Mitra A, Sarkar N
Arch Biochem Biophys 2020 Nov 30;695:108614. Epub 2020 Sep 30 doi: 10.1016/j.abb.2020.108614. PMID: 33010227
Pre-structured hydrophobic peptide β-strands: A universal amyloid trap?
Sivanesam K, Andersen N
Arch Biochem Biophys 2019 Mar 30;664:51-61. Epub 2019 Jan 29 doi: 10.1016/j.abb.2019.01.032. PMID: 30707943Free PMC Article
The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity.
Bi TM, Daggett V
Yale J Biol Med 2018 Sep;91(3):247-255. Epub 2018 Sep 21 PMID: 30258312Free PMC Article

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