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Primary focal segmental glomerulosclerosis

MedGen UID:
313617
Concept ID:
C1709661
Disease or Syndrome
Synonyms: Idiopathic Focal Segmental Glomerulosclerosis; Primary Focal Segmental Glomerulosclerosis; primary focal segmental glomerulosclerosis
 
Monarch Initiative: MONDO:0100324

Definition

Focal scarring of the glomerulus, which may result in isolated proteinuria or nephrotic syndrome, which affects only part of the glomerulus and only some of the glomeruli. The condition is considered primary in cases for which no underlying cause has been identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary focal segmental glomerulosclerosis

Professional guidelines

PubMed

Wada T, Shimizu S, Koizumi M, Sofue T, Nishiwaki H, Sasaki S, Nakaya I, Oe Y, Ishimoto T, Furuichi K, Okada H, Kurita N
Clin Exp Nephrol 2023 Sep;27(9):767-775. Epub 2023 Jun 13 doi: 10.1007/s10157-023-02366-6. PMID: 37310570
Wang L, Yu L, Wang Y, Guo Y, Zhai Z, Tang L
Sci Rep 2023 Apr 25;13(1):6740. doi: 10.1038/s41598-023-33678-y. PMID: 37185370Free PMC Article
Braun F, Homeyer I, Alachkar N, Huber TB
Cell Tissue Res 2021 Aug;385(2):423-434. Epub 2021 Apr 27 doi: 10.1007/s00441-021-03454-3. PMID: 33907872Free PMC Article

Recent clinical studies

Etiology

Boussetta A, Ben Njima K, Jellouli M, Gargah T
Tunis Med 2023 Mar 5;101(3):373-378. PMID: 38263915Free PMC Article
Wang L, Yu L, Wang Y, Guo Y, Zhai Z, Tang L
Sci Rep 2023 Apr 25;13(1):6740. doi: 10.1038/s41598-023-33678-y. PMID: 37185370Free PMC Article
Batal I, Khairallah P, Weins A, Andeen NK, Stokes MB
Front Immunol 2023;14:1124249. Epub 2023 Feb 23 doi: 10.3389/fimmu.2023.1124249. PMID: 36911713Free PMC Article
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
Crosson JT
Transplant Proc 2007 Apr;39(3):737-43. doi: 10.1016/j.transproceed.2007.02.010. PMID: 17445586

Diagnosis

Boussetta A, Ben Njima K, Jellouli M, Gargah T
Tunis Med 2023 Mar 5;101(3):373-378. PMID: 38263915Free PMC Article
Wang L, Yu L, Wang Y, Guo Y, Zhai Z, Tang L
Sci Rep 2023 Apr 25;13(1):6740. doi: 10.1038/s41598-023-33678-y. PMID: 37185370Free PMC Article
Chebotareva NV, Vinogradov A, Brzhozovskiy AG, Kashirina DN, Indeykina MI, Bugrova AE, Lebedeva M, Moiseev S, Nikolaev EN, Kononikhin AS
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012607. PMID: 36293475Free PMC Article
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article

Therapy

Salfi G, Casiraghi F, Remuzzi G
Front Immunol 2023;14:1247606. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1247606. PMID: 37795085Free PMC Article
Wang L, Yu L, Wang Y, Guo Y, Zhai Z, Tang L
Sci Rep 2023 Apr 25;13(1):6740. doi: 10.1038/s41598-023-33678-y. PMID: 37185370Free PMC Article
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
Lau EW, Ma PH, Wu X, Chung VC, Wong SY
Ren Fail 2013 Jul;35(6):914-29. Epub 2013 May 28 doi: 10.3109/0886022X.2013.794687. PMID: 23751146
Xu S, Xu G, Zeng L
J Nephrol 2012 Sep-Oct;25(5):626-35. doi: 10.5301/jn.5000092. PMID: 22344540

Prognosis

Boussetta A, Ben Njima K, Jellouli M, Gargah T
Tunis Med 2023 Mar 5;101(3):373-378. PMID: 38263915Free PMC Article
Durand A, Winkler CA, Vince N, Douillard V, Geffard E, Binns-Roemer E, Ng DK, Gourraud PA, Reidy K, Warady B, Furth S, Kopp JB, Kaskel FJ, Limou S
Am J Kidney Dis 2023 Jun;81(6):635-646.e1. Epub 2023 Jan 6 doi: 10.1053/j.ajkd.2022.11.003. PMID: 36623684
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Han KH, Kim SH
Biomed Res Int 2016;2016:3053706. Epub 2016 Apr 18 doi: 10.1155/2016/3053706. PMID: 27195285Free PMC Article
Ren H, Shen P, Li X, Pan X, Zhang Q, Feng X, Zhang W, Chen N
Contrib Nephrol 2013;181:109-18. Epub 2013 May 8 doi: 10.1159/000348468. PMID: 23689573

Clinical prediction guides

Boussetta A, Ben Njima K, Jellouli M, Gargah T
Tunis Med 2023 Mar 5;101(3):373-378. PMID: 38263915Free PMC Article
Durand A, Winkler CA, Vince N, Douillard V, Geffard E, Binns-Roemer E, Ng DK, Gourraud PA, Reidy K, Warady B, Furth S, Kopp JB, Kaskel FJ, Limou S
Am J Kidney Dis 2023 Jun;81(6):635-646.e1. Epub 2023 Jan 6 doi: 10.1053/j.ajkd.2022.11.003. PMID: 36623684
Han KH, Kim SH
Biomed Res Int 2016;2016:3053706. Epub 2016 Apr 18 doi: 10.1155/2016/3053706. PMID: 27195285Free PMC Article
Shiiki H, Dohi K
Intern Med 2000 Aug;39(8):606-11. doi: 10.2169/internalmedicine.39.606. PMID: 10939532
Korbet SM
Nephrol Dial Transplant 1999;14 Suppl 3:68-73. doi: 10.1093/ndt/14.suppl_3.68. PMID: 10382985

Recent systematic reviews

Miao J, Krisanapan P, Tangpanithandee S, Thongprayoon C, Mao MA, Cheungpasitporn W
Ren Fail 2023 Dec;45(1):2176694. doi: 10.1080/0886022X.2023.2176694. PMID: 36762994Free PMC Article
Beer A, Mayer G, Kronbichler A
Biomed Res Int 2016;2016:4192578. Epub 2016 Apr 7 doi: 10.1155/2016/4192578. PMID: 27144166Free PMC Article
Lau EW, Ma PH, Wu X, Chung VC, Wong SY
Ren Fail 2013 Jul;35(6):914-29. Epub 2013 May 28 doi: 10.3109/0886022X.2013.794687. PMID: 23751146

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