U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Primary focal segmental glomerulosclerosis

MedGen UID:
313617
•Concept ID:
C1709661
•
Disease or Syndrome
Synonyms: Idiopathic Focal Segmental Glomerulosclerosis; Primary Focal Segmental Glomerulosclerosis; primary focal segmental glomerulosclerosis
 
Monarch Initiative: MONDO:0100324

Definition

Focal scarring of the glomerulus, which may result in isolated proteinuria or nephrotic syndrome, which affects only part of the glomerulus and only some of the glomeruli. The condition is considered primary in cases for which no underlying cause has been identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary focal segmental glomerulosclerosis

Professional guidelines

PubMed

Immune-mediated entities of (primary) focal segmental glomerulosclerosis.
Braun F, Homeyer I, Alachkar N, Huber TB
Cell Tissue Res 2021 Aug;385(2):423-434. Epub 2021 Apr 27 doi: 10.1007/s00441-021-03454-3. PMID: 33907872Free PMC Article
Mycophenolate mofetil for primary focal segmental glomerulosclerosis: systematic review.
Lau EW, Ma PH, Wu X, Chung VC, Wong SY
Ren Fail 2013 Jul;35(6):914-29. Epub 2013 May 28 doi: 10.3109/0886022X.2013.794687. PMID: 23751146
Immunosuppressive treatment in primary focal segmental glomerulosclerosis.
Xu S, Xu G, Zeng L
J Nephrol 2012 Sep-Oct;25(5):626-35. doi: 10.5301/jn.5000092. PMID: 22344540

Recent clinical studies

Etiology

Primary Focal Segmental Glomerulosclerosis Recurrence After Pediatric Renal Transplantation.
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
The Symptoms and Impact of Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Conceptual Model of the Patient Experience.
English M, Hawryluk E, Krupnick R, Kumar MSA, Schwartz J
Adv Ther 2019 Dec;36(12):3390-3408. Epub 2019 Oct 14 doi: 10.1007/s12325-019-01110-5. PMID: 31612357Free PMC Article
Disease Recurrence-The Sword of Damocles in Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis.
Kienzl-Wagner K, Waldegger S, Schneeberger S
Front Immunol 2019;10:1669. Epub 2019 Jul 17 doi: 10.3389/fimmu.2019.01669. PMID: 31379860Free PMC Article
Immunosuppressive treatment in primary focal segmental glomerulosclerosis.
Xu S, Xu G, Zeng L
J Nephrol 2012 Sep-Oct;25(5):626-35. doi: 10.5301/jn.5000092. PMID: 22344540
Focal segmental glomerulosclerosis and renal transplantation.
Crosson JT
Transplant Proc 2007 Apr;39(3):737-43. doi: 10.1016/j.transproceed.2007.02.010. PMID: 17445586

Diagnosis

Rituximab treatment of adults with primary focal segmental glomerulosclerosis.
Wang L, Yu L, Wang Y, Guo Y, Zhai Z, Tang L
Sci Rep 2023 Apr 25;13(1):6740. doi: 10.1038/s41598-023-33678-y. PMID: 37185370Free PMC Article
Extracellular vesicles from focal segmental glomerulosclerosis pediatric patients induce STAT3 activation and mesangial cell proliferation.
Pekkucuksen NT, Liu LP, Aly R, Shoemaker LR, Alli AA
PLoS One 2022;17(11):e0274598. Epub 2022 Nov 14 doi: 10.1371/journal.pone.0274598. PMID: 36374911Free PMC Article
Potential Urine Proteomic Biomarkers for Focal Segmental Glomerulosclerosis and Minimal Change Disease.
Chebotareva NV, Vinogradov A, Brzhozovskiy AG, Kashirina DN, Indeykina MI, Bugrova AE, Lebedeva M, Moiseev S, Nikolaev EN, Kononikhin AS
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012607. PMID: 36293475Free PMC Article
Primary Focal Segmental Glomerulosclerosis Recurrence After Pediatric Renal Transplantation.
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
Lupus Podocytopathy: An Overview.
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article

Therapy

Primary Focal Segmental Glomerulosclerosis Recurrence After Pediatric Renal Transplantation.
Baskın E, Avcı B, Gülleroğlu K, Akdur A, Moray G, Haberal M
Exp Clin Transplant 2022 Mar;20(Suppl 1):55-60. doi: 10.6002/ect.MESOT2021.O24. PMID: 35384808
The Symptoms and Impact of Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Conceptual Model of the Patient Experience.
English M, Hawryluk E, Krupnick R, Kumar MSA, Schwartz J
Adv Ther 2019 Dec;36(12):3390-3408. Epub 2019 Oct 14 doi: 10.1007/s12325-019-01110-5. PMID: 31612357Free PMC Article
Disease Recurrence-The Sword of Damocles in Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis.
Kienzl-Wagner K, Waldegger S, Schneeberger S
Front Immunol 2019;10:1669. Epub 2019 Jul 17 doi: 10.3389/fimmu.2019.01669. PMID: 31379860Free PMC Article
Mycophenolate mofetil for primary focal segmental glomerulosclerosis: systematic review.
Lau EW, Ma PH, Wu X, Chung VC, Wong SY
Ren Fail 2013 Jul;35(6):914-29. Epub 2013 May 28 doi: 10.3109/0886022X.2013.794687. PMID: 23751146
Immunosuppressive treatment in primary focal segmental glomerulosclerosis.
Xu S, Xu G, Zeng L
J Nephrol 2012 Sep-Oct;25(5):626-35. doi: 10.5301/jn.5000092. PMID: 22344540

Prognosis

Kidney Outcome in Primary Focal Segmental Glomerulosclerosis (FSGS) by Using a Predictive Model.
Ossareh S, Yahyaei M, Asgari M, Bagherzadegan H, Afghahi H
Iran J Kidney Dis 2021 Dec;15(6):408-418. PMID: 34930852
Lupus Podocytopathy: An Overview.
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Recent Advances in Treatments of Primary Focal Segmental Glomerulosclerosis in Children.
Han KH, Kim SH
Biomed Res Int 2016;2016:3053706. Epub 2016 Apr 18 doi: 10.1155/2016/3053706. PMID: 27195285Free PMC Article
Treatment of idiopathic focal segmental glomerulosclerosis: options in the event of resistance to corticosteroids and calcineurin inhibitors.
Segarra-Medrano A, Jatem-Escalante E, Agraz-Pamplona I, Carnicer-Cáceres C, Ramos-Terrades N, Ostos-Roldán E, Quiles-Pérez MT, Arbós-Via MA
Nefrologia 2013;33(4):448-61. doi: 10.3265/Nefrologia.pre2013.Jan.11871. PMID: 23897176
Primary focal segmental glomerulosclerosis.
Korbet SM
J Am Soc Nephrol 1998 Jul;9(7):1333-40. doi: 10.1681/ASN.V971333. PMID: 9644647

Clinical prediction guides

Potential Urine Proteomic Biomarkers for Focal Segmental Glomerulosclerosis and Minimal Change Disease.
Chebotareva NV, Vinogradov A, Brzhozovskiy AG, Kashirina DN, Indeykina MI, Bugrova AE, Lebedeva M, Moiseev S, Nikolaev EN, Kononikhin AS
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012607. PMID: 36293475Free PMC Article
Clinical Significance of Urinary Biomarkers in Patients With Primary Focal Segmental Glomerulosclerosis.
Zhang Q, Jiang C, Tang T, Wang H, Xia Y, Shao Q, Zhang M
Am J Med Sci 2018 Apr;355(4):314-321. Epub 2017 Dec 30 doi: 10.1016/j.amjms.2017.12.019. PMID: 29661344
Recent Advances in Treatments of Primary Focal Segmental Glomerulosclerosis in Children.
Han KH, Kim SH
Biomed Res Int 2016;2016:3053706. Epub 2016 Apr 18 doi: 10.1155/2016/3053706. PMID: 27195285Free PMC Article
Primary focal segmental glomerulosclerosis: clinical course, predictors of renal outcome and treatment.
Shiiki H, Dohi K
Intern Med 2000 Aug;39(8):606-11. doi: 10.2169/internalmedicine.39.606. PMID: 10939532
Clinical picture and outcome of primary focal segmental glomerulosclerosis.
Korbet SM
Nephrol Dial Transplant 1999;14 Suppl 3:68-73. doi: 10.1093/ndt/14.suppl_3.68. PMID: 10382985

Recent systematic reviews

Efficacy of extracorporeal plasma therapy for adult native kidney patients with Primary FSGS: a Systematic review.
Miao J, Krisanapan P, Tangpanithandee S, Thongprayoon C, Mao MA, Cheungpasitporn W
Ren Fail 2023 Dec;45(1):2176694. doi: 10.1080/0886022X.2023.2176694. PMID: 36762994Free PMC Article
Treatment Strategies of Adult Primary Focal Segmental Glomerulosclerosis: A Systematic Review Focusing on the Last Two Decades.
Beer A, Mayer G, Kronbichler A
Biomed Res Int 2016;2016:4192578. Epub 2016 Apr 7 doi: 10.1155/2016/4192578. PMID: 27144166Free PMC Article
Mycophenolate mofetil for primary focal segmental glomerulosclerosis: systematic review.
Lau EW, Ma PH, Wu X, Chung VC, Wong SY
Ren Fail 2013 Jul;35(6):914-29. Epub 2013 May 28 doi: 10.3109/0886022X.2013.794687. PMID: 23751146

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...