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Appendix Traditional Serrated Adenoma

MedGen UID:
313962
•Concept ID:
C1711169
•
Neoplastic Process
Synonyms: Appendix Serrated Adenoma; Appendix Serrated Adenoma Type II; Appendix TSA

Definition

An adenoma that arises from the appendix. It is characterized by prominent serration of the glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Traditional Serrated Adenoma

Recent clinical studies

Etiology

Serrated lesions of the appendix in serrated polyposis patients.
Bettington M, Brown IS, Rosty C
Pathology 2016 Jan;48(1):30-4. Epub 2015 Dec 18 doi: 10.1016/j.pathol.2015.11.012. PMID: 27020206
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix.
Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Downs-Kelly E, Goldblum JR, Liu X, Patil DT, Bennett AE, Plesec TP, Kuan SF, Nikiforova MN, Shadrach B, Pai RK
Hum Pathol 2014 Feb;45(2):227-35. Epub 2013 Oct 30 doi: 10.1016/j.humpath.2013.10.021. PMID: 24439221

Diagnosis

The inverted appendix - a potentially problematic diagnosis: clinicopathologic analysis of 21 cases.
Birkness J, Lam-Himlin D, Byrnes K, Wood L, Voltaggio L
Histopathology 2019 May;74(6):853-860. Epub 2019 Mar 20 doi: 10.1111/his.13824. PMID: 30667075
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix.
Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Downs-Kelly E, Goldblum JR, Liu X, Patil DT, Bennett AE, Plesec TP, Kuan SF, Nikiforova MN, Shadrach B, Pai RK
Hum Pathol 2014 Feb;45(2):227-35. Epub 2013 Oct 30 doi: 10.1016/j.humpath.2013.10.021. PMID: 24439221
Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia.
Longacre TA, Fenoglio-Preiser CM
Am J Surg Pathol 1990 Jun;14(6):524-37. doi: 10.1097/00000478-199006000-00003. PMID: 2186644

Clinical prediction guides

Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127

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