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Enchondroma

MedGen UID:
316457
•Concept ID:
C1704356
•
Neoplastic Process
Synonym: Enchondromas
SNOMED CT: Enchondroma (423699002); True chondroma (423699002)
 
HPO: HP:0030038

Definition

A solitary, benign, intramedullary cartilage tumor that is often found in the short tubular bones of the hands and feet, distal femur, and proximal humerus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnchondroma

Professional guidelines

PubMed

Conventional Cartilaginous Tumors: Evaluation and Treatment.
Wells ME, Eckhoff MD, Kafchinski LA, Polfer EM, Potter BK
JBJS Rev 2021 May 6;9(5) doi: 10.2106/JBJS.RVW.20.00159. PMID: 34881859
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Current management of hand enchondroma: a review.
Tang C, Chan M, Fok M, Fung B
Hand Surg 2015;20(1):191-5. doi: 10.1142/S0218810415300028. PMID: 25609298

Recent clinical studies

Etiology

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Update on the imaging features of the enchondromatosis syndromes.
Sharif B, Lindsay D, Saifuddin A
Skeletal Radiol 2022 Apr;51(4):747-762. Epub 2021 Jul 24 doi: 10.1007/s00256-021-03870-0. PMID: 34302201
Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178

Diagnosis

Chondroid Tumors of Bone.
Haygood TM, Amini B
Semin Ultrasound CT MR 2021 Apr;42(2):123-133. Epub 2020 Aug 29 doi: 10.1053/j.sult.2020.08.017. PMID: 33814100
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Biomarkers of chondrosarcoma.
Jeong W, Kim HJ
J Clin Pathol 2018 Jul;71(7):579-583. Epub 2018 Mar 28 doi: 10.1136/jclinpath-2018-205071. PMID: 29593061Free PMC Article
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Enchondroma and chondrosarcoma.
Flemming DJ, Murphey MD
Semin Musculoskelet Radiol 2000;4(1):59-71. doi: 10.1055/s-2000-6855. PMID: 11061692

Therapy

Clinical and Radiological Outcome of Osteoscopic-Assisted Treatment of Enchondroma in Hand with Artificial Bone Substitute or Bone Graft: A 7-Year Case Series and Literature Review.
Yung WTB, Koo SCJJ, Mak CKM, Yu WPF, Tse WL, Ho PC
J Hand Surg Asian Pac Vol 2023 Apr;28(2):214-224. doi: 10.1142/S2424835523500236. PMID: 37120310
Impact of Patient and Tumor Characteristics on Range of Motion and Recurrence Following Treatment of Enchondromas of the Hand.
Wessel LE, Christ AB, Athanasian EA
J Hand Surg Am 2023 May;48(5):512.e1-512.e7. Epub 2022 Jan 31 doi: 10.1016/j.jhsa.2021.11.027. PMID: 35115192Free PMC Article
Large enchondroma of the thoracic spine: a rare case report and review of the literature.
Guo J, Gao JZ, Guo LJ, Yin ZX, He EX
BMC Musculoskelet Disord 2017 Apr 13;18(1):155. doi: 10.1186/s12891-017-1519-z. PMID: 28407736Free PMC Article
Current management of hand enchondroma: a review.
Tang C, Chan M, Fok M, Fung B
Hand Surg 2015;20(1):191-5. doi: 10.1142/S0218810415300028. PMID: 25609298
The etiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:15-32. doi: 10.1007/978-1-4419-0284-9_2. PMID: 20213384

Prognosis

Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature.
El Abiad JM, Robbins SM, Cohen B, Levin AS, Valle DL, Morris CD, de Macena Sobreira NL
Am J Med Genet A 2020 May;182(5):1093-1103. Epub 2020 Mar 7 doi: 10.1002/ajmg.a.61530. PMID: 32144835Free PMC Article
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Biomarkers of chondrosarcoma.
Jeong W, Kim HJ
J Clin Pathol 2018 Jul;71(7):579-583. Epub 2018 Mar 28 doi: 10.1136/jclinpath-2018-205071. PMID: 29593061Free PMC Article
Ollier disease.
D'Angelo L, Massimi L, Narducci A, Di Rocco C
Childs Nerv Syst 2009 Jun;25(6):647-53. Epub 2009 Mar 27 doi: 10.1007/s00381-009-0873-z. PMID: 19326125

Clinical prediction guides

Solitary enchondromas-diagnosis and surveillance : Danish guidelines.
Jurik AG, Hansen BH, Weber K
Radiologe 2020 Nov;60(Suppl 1):26-32. doi: 10.1007/s00117-020-00681-7. PMID: 32322923
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Biomarkers of chondrosarcoma.
Jeong W, Kim HJ
J Clin Pathol 2018 Jul;71(7):579-583. Epub 2018 Mar 28 doi: 10.1136/jclinpath-2018-205071. PMID: 29593061Free PMC Article
Enchondroma of the Foot.
Chun KA, Stephanie S, Choi JY, Nam JH, Suh JS
J Foot Ankle Surg 2015 Sep-Oct;54(5):836-9. Epub 2015 May 27 doi: 10.1053/j.jfas.2015.01.002. PMID: 26024560
The etiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:15-32. doi: 10.1007/978-1-4419-0284-9_2. PMID: 20213384

Recent systematic reviews

F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature.
Subhawong TK, Winn A, Shemesh SS, Pretell-Mazzini J
Skeletal Radiol 2017 Sep;46(9):1233-1239. Epub 2017 Jun 12 doi: 10.1007/s00256-017-2685-7. PMID: 28608242

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