U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neuroectodermal Differentiation

MedGen UID:
317949
•Concept ID:
C1709217
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroectodermal Differentiation

Professional guidelines

PubMed

Malignant gastrointestinal neuroectodermal tumor in head and neck: two challenging cases with diverse morphology and different considerations for differential diagnosis.
Kuo CT, Kao YC, Huang HY, Hsiao CH, Lee JC
Virchows Arch 2022 Jul;481(1):131-136. Epub 2022 Jan 18 doi: 10.1007/s00428-022-03274-y. PMID: 35039897

Recent clinical studies

Etiology

Glioblastoma with Primitive Neuroectodermal Component Treated with Adjuvant Radiotherapy and Temozolomide: A Pooled Analysis of 23 Patients.
Benson R, Mallick S, Purkait S, Haresh KP, Gupta S, Sharma MC, Suri V, Sharma D, Rath GK
Neurol India 2021 Jul-Aug;69(4):856-860. doi: 10.4103/0028-3886.323892. PMID: 34507401
DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
Pancaldi A, Peng L, Rhee DS, Dunn E, Forcucci JA, Belchis D, Pratilas CA
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005603. PMID: 33028642Free PMC Article
Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29-year-old Chinese female: a case report and published work review.
Yi T, Wang P, Lin L, Jiang W
J Obstet Gynaecol Res 2015 Mar;41(3):478-82. Epub 2014 Oct 10 doi: 10.1111/jog.12552. PMID: 25303625
A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma.
Sprecher E, Ishida-Yamamoto A, Mizrahi-Koren M, Rapaport D, Goldsher D, Indelman M, Topaz O, Chefetz I, Keren H, O'brien TJ, Bercovich D, Shalev S, Geiger D, Bergman R, Horowitz M, Mandel H
Am J Hum Genet 2005 Aug;77(2):242-51. Epub 2005 Jun 20 doi: 10.1086/432556. PMID: 15968592Free PMC Article
Peripheral neuroectodermal tumors of the chest wall in childhood.
Gonzalez-Crussi F, Wolfson SL, Misugi K, Nakajima T
Cancer 1984 Dec 1;54(11):2519-27. doi: 10.1002/1097-0142(19841201)54:11<2519::aid-cncr2820541135>3.0.co;2-v. PMID: 6093982

Diagnosis

Primary retroperitoneal Ewings sarcoma.
Spacek J, Kopeckova K, Kosina J, Pacovsky J, Petera J, Krbal L, Mrhalová M, Dvorak P, Broďák M
Rozhl Chir 2019 Winter;98(3):121-124. PMID: 31018644
Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29-year-old Chinese female: a case report and published work review.
Yi T, Wang P, Lin L, Jiang W
J Obstet Gynaecol Res 2015 Mar;41(3):478-82. Epub 2014 Oct 10 doi: 10.1111/jog.12552. PMID: 25303625
Ewing sarcoma family of tumors.
Khoury JD
Adv Anat Pathol 2005 Jul;12(4):212-20. doi: 10.1097/01.pap.0000175114.55541.52. PMID: 16096383
Neuroendocrine neoplasms of the lung.
Cerilli LA, Ritter JH, Mills SE, Wick MR
Am J Clin Pathol 2001 Dec;116 Suppl:S65-96. doi: 10.1309/BPY4-VGTB-PATF-VUXU. PMID: 11993704
Carcinosarcoma of the uterus with extensive neuroectodermal differentiation.
Fukunaga M, Nomura K, Endo Y, Ushigome S, Aizawa S
Histopathology 1996 Dec;29(6):565-70. doi: 10.1046/j.1365-2559.1996.d01-532.x. PMID: 8971564

Therapy

Glioblastoma with Primitive Neuroectodermal Component Treated with Adjuvant Radiotherapy and Temozolomide: A Pooled Analysis of 23 Patients.
Benson R, Mallick S, Purkait S, Haresh KP, Gupta S, Sharma MC, Suri V, Sharma D, Rath GK
Neurol India 2021 Jul-Aug;69(4):856-860. doi: 10.4103/0028-3886.323892. PMID: 34507401
Primary vaginal Ewing sarcoma: case report and review of the literature.
Bancalari E, de Álava E, Tardío JC
Int J Surg Pathol 2012 Jun;20(3):305-10. Epub 2011 Oct 17 doi: 10.1177/1066896911424898. PMID: 22007080
Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype.
Amant F, Tousseyn T, Coenegrachts L, Decloedt J, Moerman P, Debiec-Rychter M
Anticancer Res 2011 Jun;31(6):2367-71. PMID: 21737666
Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategies.
Hermann A, List C, Habisch HJ, Vukicevic V, Ehrhart-Bornstein M, Brenner R, Bernstein P, Fickert S, Storch A
Cytotherapy 2010;12(1):17-30. doi: 10.3109/14653240903313941. PMID: 19878082
Coordinate changes in neuronal phenotype and surface antigen expression in human neuroblastoma cell variants.
Rettig WJ, Spengler BA, Chesa PG, Old LJ, Biedler JL
Cancer Res 1987 Mar 1;47(5):1383-9. PMID: 3028608

Prognosis

DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
Pancaldi A, Peng L, Rhee DS, Dunn E, Forcucci JA, Belchis D, Pratilas CA
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005603. PMID: 33028642Free PMC Article
Immature teratoma presenting as a soft-tissue mass with no evidence of other sites of involvement: a case report.
Zuquello RÁ, Tagliari G, Bagatini R, Camiña RH, Caron R, Lorencette NA, Baptistella AR, Manfro G
Diagn Pathol 2016 Aug 15;11(1):76. doi: 10.1186/s13000-016-0527-x. PMID: 27528018Free PMC Article
Embryonal tumor with abundant neuropil and true rosettes with melanotic (retinal) differentiation.
Majumdar K, Batra VV, Tyagi I, Sharma A
Fetal Pediatr Pathol 2013 Dec;32(6):429-36. Epub 2013 May 20 doi: 10.3109/15513815.2013.799250. PMID: 23688420
Ovarian malignant mixed mullerian tumor with primitive neuroectodermal differentiation: case report with review of the literature.
Nasser H, Morris RT, Fathallah L
Pathol Res Pract 2011 Mar 15;207(3):202-6. Epub 2010 Oct 14 doi: 10.1016/j.prp.2010.08.003. PMID: 20950943
Ewing sarcoma family of tumors.
Khoury JD
Adv Anat Pathol 2005 Jul;12(4):212-20. doi: 10.1097/01.pap.0000175114.55541.52. PMID: 16096383

Clinical prediction guides

Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation.
Beck DB, Basar MA, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network, Matsumoto N, Inazawa J, Walkiewicz M, Õunap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A
Sci Adv 2021 Jan;7(4) Epub 2021 Jan 20 doi: 10.1126/sciadv.abe2116. PMID: 33523931Free PMC Article
Primary vaginal Ewing sarcoma: case report and review of the literature.
Bancalari E, de Álava E, Tardío JC
Int J Surg Pathol 2012 Jun;20(3):305-10. Epub 2011 Oct 17 doi: 10.1177/1066896911424898. PMID: 22007080
Ovarian malignant mixed mullerian tumor with primitive neuroectodermal differentiation: case report with review of the literature.
Nasser H, Morris RT, Fathallah L
Pathol Res Pract 2011 Mar 15;207(3):202-6. Epub 2010 Oct 14 doi: 10.1016/j.prp.2010.08.003. PMID: 20950943
Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells.
Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH
FEBS Lett 2006 Oct 30;580(25):5869-74. Epub 2006 Oct 2 doi: 10.1016/j.febslet.2006.09.053. PMID: 17027979
Coordinate changes in neuronal phenotype and surface antigen expression in human neuroblastoma cell variants.
Rettig WJ, Spengler BA, Chesa PG, Old LJ, Biedler JL
Cancer Res 1987 Mar 1;47(5):1383-9. PMID: 3028608

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...