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RET/PTC Rearrangement

MedGen UID:
318094
•Concept ID:
C1709815
•
Cell or Molecular Dysfunction
Synonyms: RET Gene Rearrangement; Ret Proto-Oncogene Rearrangement; RET Rearrangement

Definition

A gene rearrangement involving the RET proto-oncogene. RET gene rearrangements are associated with several different neoplastic conditions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRET/PTC Rearrangement

Professional guidelines

PubMed

Pharmacological and clinical profile of lenvatinib (E-7080) in the treatment of advanced, radioiodine-refractory, differentiated thyroid cancer.
Hegazi M, Azadi A, Jain D, Redman R, Perez CA
Drugs Today (Barc) 2015 Dec;51(12):689-94. doi: 10.1358/dot.2015.51.12.2420390. PMID: 26798849
Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis.
Nikiforova MN, Nikiforov YE
Expert Rev Mol Diagn 2008 Jan;8(1):83-95. doi: 10.1586/14737159.8.1.83. PMID: 18088233

Recent clinical studies

Etiology

Ultrasound images-based deep learning radiomics nomogram for preoperative prediction of RET rearrangement in papillary thyroid carcinoma.
Yu J, Zhang Y, Zheng J, Jia M, Lu X
Front Endocrinol (Lausanne) 2022;13:1062571. Epub 2022 Dec 20 doi: 10.3389/fendo.2022.1062571. PMID: 36605945Free PMC Article
Detection of RET rearrangements in papillary thyroid carcinoma using RT-PCR and FISH techniques - A molecular and clinical analysis.
Musholt TJ, Staubitz JI, Antonio Cámara RJ, Musholt PB, Humberg D, Springer E, Schad A
Eur J Surg Oncol 2019 Jun;45(6):1018-1024. Epub 2018 Nov 16 doi: 10.1016/j.ejso.2018.11.009. PMID: 30472213
RET/PTC Rearrangements Are Associated with Elevated Postoperative TSH Levels and Multifocal Lesions in Papillary Thyroid Cancer without Concomitant Thyroid Benign Disease.
Su X, He C, Ma J, Tang T, Zhang X, Ye Z, Long Y, Shao Q, Shao J, Yang A
PLoS One 2016;11(11):e0165596. Epub 2016 Nov 1 doi: 10.1371/journal.pone.0165596. PMID: 27802347Free PMC Article
The thyroid gland: a crossroad in inflammation-induced carcinoma? An ongoing debate with new therapeutic potential.
Bozec A, Lassalle S, Hofman V, Ilie M, Santini J, Hofman P
Curr Med Chem 2010;17(30):3449-61. doi: 10.2174/092986710792927804. PMID: 20738253
BRAF mutation in thyroid cancer.
Xing M
Endocr Relat Cancer 2005 Jun;12(2):245-62. doi: 10.1677/erc.1.0978. PMID: 15947100

Diagnosis

Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770
Pediatric thyroid cancer.
Diesen DL, Skinner MA
Semin Pediatr Surg 2012 Feb;21(1):44-50. doi: 10.1053/j.sempedsurg.2011.10.004. PMID: 22248969
RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint.
Marotta V, Guerra A, Sapio MR, Vitale M
Eur J Endocrinol 2011 Oct;165(4):499-507. Epub 2011 Jul 12 doi: 10.1530/EJE-11-0499. PMID: 21750045
Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application.
Guerra A, Sapio MR, Marotta V, Campanile E, Moretti MI, Deandrea M, Motta M, Limone PP, Fenzi G, Rossi G, Vitale M
Endocr J 2011;58(1):31-8. Epub 2010 Dec 14 doi: 10.1507/endocrj.k10e-260. PMID: 21173509
BRAF mutation in thyroid cancer.
Xing M
Endocr Relat Cancer 2005 Jun;12(2):245-62. doi: 10.1677/erc.1.0978. PMID: 15947100

Therapy

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.
Iancu IV, Botezatu A, Plesa A, Huica I, Fudulu A, Albulescu A, Bostan M, Mihaila M, Grancea C, Manda DA, Dobrescu R, Vladoiu SV, Anton G, Badiu CV
Cancer Biomark 2020;28(2):255-268. doi: 10.3233/CBM-190871. PMID: 32390600
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
Cui D, Zhao Y, Xu J
Cancer Biol Ther 2019;20(5):608-616. Epub 2018 Nov 7 doi: 10.1080/15384047.2018.1539289. PMID: 30404567Free PMC Article
Pharmacological and clinical profile of lenvatinib (E-7080) in the treatment of advanced, radioiodine-refractory, differentiated thyroid cancer.
Hegazi M, Azadi A, Jain D, Redman R, Perez CA
Drugs Today (Barc) 2015 Dec;51(12):689-94. doi: 10.1358/dot.2015.51.12.2420390. PMID: 26798849
Thyroid carcinoma: molecular pathways and therapeutic targets.
Nikiforov YE
Mod Pathol 2008 May;21 Suppl 2(Suppl 2):S37-43. doi: 10.1038/modpathol.2008.10. PMID: 18437172Free PMC Article
RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults.
Elisei R, Romei C, Vorontsova T, Cosci B, Veremeychik V, Kuchinskaya E, Basolo F, Demidchik EP, Miccoli P, Pinchera A, Pacini F
J Clin Endocrinol Metab 2001 Jul;86(7):3211-6. doi: 10.1210/jcem.86.7.7678. PMID: 11443191

Prognosis

Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770
Pediatric thyroid cancer.
Diesen DL, Skinner MA
Semin Pediatr Surg 2012 Feb;21(1):44-50. doi: 10.1053/j.sempedsurg.2011.10.004. PMID: 22248969
Clinical prognosis in BRAF-mutated PTC.
Puxeddu E, Moretti S
Arq Bras Endocrinol Metabol 2007 Jul;51(5):736-47. doi: 10.1590/s0004-27302007000500011. PMID: 17891237
BRAF mutation in thyroid cancer.
Xing M
Endocr Relat Cancer 2005 Jun;12(2):245-62. doi: 10.1677/erc.1.0978. PMID: 15947100
RET/PTC rearrangement in thyroid tumors.
Nikiforov YE
Endocr Pathol 2002 Spring;13(1):3-16. doi: 10.1385/ep:13:1:03. PMID: 12114746

Clinical prediction guides

Ultrasound images-based deep learning radiomics nomogram for preoperative prediction of RET rearrangement in papillary thyroid carcinoma.
Yu J, Zhang Y, Zheng J, Jia M, Lu X
Front Endocrinol (Lausanne) 2022;13:1062571. Epub 2022 Dec 20 doi: 10.3389/fendo.2022.1062571. PMID: 36605945Free PMC Article
Emerging Role of Oxidative Stress on EGFR and OGG1-BER Cross-Regulation: Implications in Thyroid Physiopathology.
Moscatello C, Di Marcantonio MC, Savino L, D'Amico E, Spacco G, Simeone P, Lanuti P, Muraro R, Mincione G, Cotellese R, Aceto GM
Cells 2022 Feb 26;11(5) doi: 10.3390/cells11050822. PMID: 35269445Free PMC Article
RET/PTC Gene Rearrangements in Thyroid Carcinogenesis: Assessment and Clinico-Pathological Correlations.
Khan MS, Qadri Q, Makhdoomi MJ, Wani MA, Malik AA, Niyaz M, Masoodi SR, Andrabi KI, Ahmad R, Mudassar S
Pathol Oncol Res 2020 Jan;26(1):507-513. Epub 2018 Nov 22 doi: 10.1007/s12253-018-0540-3. PMID: 30467698
HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.
Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, Koenig RJ, Nikiforov YE
Endocr Relat Cancer 2007 Jun;14(2):445-52. doi: 10.1677/ERC-07-0039. PMID: 17639057
RET/PTC rearrangement in thyroid tumors.
Nikiforov YE
Endocr Pathol 2002 Spring;13(1):3-16. doi: 10.1385/ep:13:1:03. PMID: 12114746

Recent systematic reviews

Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770

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