U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Receptor Tyrosine Kinase Gene Rearrangement

MedGen UID:
1655862
Concept ID:
C4744517
Cell or Molecular Dysfunction
Synonyms: Receptor Tyrosine Kinase Family Gene Rearrangement; Receptor Tyrosine Kinase Rearrangement; RTK Family Gene Rearrangement; RTK Family Rearrangement; RTK Gene Rearrangement; RTK Rearrangement; Tyrosine Kinase Receptor Family Rearrangement; Tyrosine Kinase Receptor Gene Rearrangement; Tyrosine Kinase Receptor Rearrangement

Definition

A molecular abnormality indicating rearrangement of a receptor tyrosine kinase family gene. [from NCI]

Professional guidelines

PubMed

Doebele RC, Lu X, Sumey C, Maxson DA, Weickhardt AJ, Oton AB, Bunn PA Jr, Barón AE, Franklin WA, Aisner DL, Varella-Garcia M, Camidge DR
Cancer 2012 Sep 15;118(18):4502-11. Epub 2012 Jan 26 doi: 10.1002/cncr.27409. PMID: 22282022Free PMC Article

Recent clinical studies

Etiology

Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article
Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, Riely GJ, Tan EH, Seto T, James LP, Clancy JS, Abbattista A, Martini JF, Chen J, Peltz G, Thurm H, Ou SI, Shaw AT
Lancet Oncol 2018 Dec;19(12):1654-1667. Epub 2018 Nov 6 doi: 10.1016/S1470-2045(18)30649-1. PMID: 30413378
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM, Chen H, Wilner KD, Kwak EL, Clark JW, Carbone DP, Ji H, Engelman JA, Mino-Kenudson M, Pao W, Iafrate AJ
J Clin Oncol 2012 Mar 10;30(8):863-70. Epub 2012 Jan 3 doi: 10.1200/JCO.2011.35.6345. PMID: 22215748Free PMC Article

Diagnosis

Davis JL, Al-Ibraheemi A, Rudzinski ER, Surrey LF
Histopathology 2022 Jan;80(1):4-18. doi: 10.1111/his.14443. PMID: 34958503
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Golding B, Luu A, Jones R, Viloria-Petit AM
Mol Cancer 2018 Feb 19;17(1):52. doi: 10.1186/s12943-018-0810-4. PMID: 29455675Free PMC Article
Hechtman JF, Benayed R, Hyman DM, Drilon A, Zehir A, Frosina D, Arcila ME, Dogan S, Klimstra DS, Ladanyi M, Jungbluth AA
Am J Surg Pathol 2017 Nov;41(11):1547-1551. doi: 10.1097/PAS.0000000000000911. PMID: 28719467Free PMC Article
Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM, Chen H, Wilner KD, Kwak EL, Clark JW, Carbone DP, Ji H, Engelman JA, Mino-Kenudson M, Pao W, Iafrate AJ
J Clin Oncol 2012 Mar 10;30(8):863-70. Epub 2012 Jan 3 doi: 10.1200/JCO.2011.35.6345. PMID: 22215748Free PMC Article

Therapy

Gendarme S, Bylicki O, Chouaid C, Guisier F
Curr Oncol 2022 Jan 28;29(2):641-658. doi: 10.3390/curroncol29020057. PMID: 35200557Free PMC Article
Du X, Shao Y, Qin HF, Tai YH, Gao HJ
Thorac Cancer 2018 Apr;9(4):423-430. Epub 2018 Feb 28 doi: 10.1111/1759-7714.12613. PMID: 29488330Free PMC Article
Du Z, Lovly CM
Mol Cancer 2018 Feb 19;17(1):58. doi: 10.1186/s12943-018-0782-4. PMID: 29455648Free PMC Article
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ
N Engl J Med 2014 Nov 20;371(21):1963-71. Epub 2014 Sep 27 doi: 10.1056/NEJMoa1406766. PMID: 25264305Free PMC Article

Prognosis

Shi Y, Lei Y, Liu L, Zhang S, Wang W, Zhao J, Zhao S, Dong X, Yao M, Wang K, Zhou Q
Cancer Med 2021 Apr;10(7):2216-2231. Epub 2021 Mar 2 doi: 10.1002/cam4.3649. PMID: 33655698Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Hechtman JF, Benayed R, Hyman DM, Drilon A, Zehir A, Frosina D, Arcila ME, Dogan S, Klimstra DS, Ladanyi M, Jungbluth AA
Am J Surg Pathol 2017 Nov;41(11):1547-1551. doi: 10.1097/PAS.0000000000000911. PMID: 28719467Free PMC Article
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030

Clinical prediction guides

Mizuta H, Okada K, Araki M, Adachi J, Takemoto A, Kutkowska J, Maruyama K, Yanagitani N, Oh-Hara T, Watanabe K, Tamai K, Friboulet L, Katayama K, Ma B, Sasakura Y, Sagae Y, Kukimoto-Niino M, Shirouzu M, Takagi S, Simizu S, Nishio M, Okuno Y, Fujita N, Katayama R
Nat Commun 2021 Feb 24;12(1):1261. doi: 10.1038/s41467-021-21396-w. PMID: 33627640Free PMC Article
Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, Riely GJ, Tan EH, Seto T, James LP, Clancy JS, Abbattista A, Martini JF, Chen J, Peltz G, Thurm H, Ou SI, Shaw AT
Lancet Oncol 2018 Dec;19(12):1654-1667. Epub 2018 Nov 6 doi: 10.1016/S1470-2045(18)30649-1. PMID: 30413378
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ
N Engl J Med 2014 Nov 20;371(21):1963-71. Epub 2014 Sep 27 doi: 10.1056/NEJMoa1406766. PMID: 25264305Free PMC Article

Recent systematic reviews

White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Kim TH, Woo S, Yoon SH, Halpenny DF, Han S, Suh CH
AJR Am J Roentgenol 2019 Nov;213(5):1059-1072. Epub 2019 Aug 15 doi: 10.2214/AJR.19.21485. PMID: 31414902Free PMC Article
Li G, Dai WR, Shao FC
Eur Rev Med Pharmacol Sci 2017 Aug;21(15):3496-3503. PMID: 28829490
Ma H, Yao WX, Huang L, Jin SH, Liu DH, Liu Y, Tian X, Tian JH, Zhou JG
Oncotarget 2016 Oct 25;7(43):70128-70142. doi: 10.18632/oncotarget.11806. PMID: 27602773Free PMC Article
Pyo JS, Kang G, Sohn JH
Int J Biol Markers 2016 Dec 23;31(4):e413-e421. doi: 10.5301/jbm.5000218. PMID: 27338643

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...