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Receptor Tyrosine Kinase Gene Rearrangement

MedGen UID:
1655862
Concept ID:
C4744517
Cell or Molecular Dysfunction
Synonyms: Receptor Tyrosine Kinase Family Gene Rearrangement; Receptor Tyrosine Kinase Rearrangement; RTK Family Gene Rearrangement; RTK Family Rearrangement; RTK Gene Rearrangement; RTK Rearrangement; Tyrosine Kinase Receptor Family Rearrangement; Tyrosine Kinase Receptor Gene Rearrangement; Tyrosine Kinase Receptor Rearrangement

Definition

A molecular abnormality indicating rearrangement of a receptor tyrosine kinase family gene. [from NCI]

Professional guidelines

PubMed

Doebele RC, Lu X, Sumey C, Maxson DA, Weickhardt AJ, Oton AB, Bunn PA Jr, Barón AE, Franklin WA, Aisner DL, Varella-Garcia M, Camidge DR
Cancer 2012 Sep 15;118(18):4502-11. Epub 2012 Jan 26 doi: 10.1002/cncr.27409. PMID: 22282022Free PMC Article

Recent clinical studies

Etiology

Shi Y, Lei Y, Liu L, Zhang S, Wang W, Zhao J, Zhao S, Dong X, Yao M, Wang K, Zhou Q
Cancer Med 2021 Apr;10(7):2216-2231. Epub 2021 Mar 2 doi: 10.1002/cam4.3649. PMID: 33655698Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Silverman IM, Hollebecque A, Friboulet L, Owens S, Newton RC, Zhen H, Féliz L, Zecchetto C, Melisi D, Burn TC
Cancer Discov 2021 Feb;11(2):326-339. Epub 2020 Nov 20 doi: 10.1158/2159-8290.CD-20-0766. PMID: 33218975
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article
Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, Riely GJ, Tan EH, Seto T, James LP, Clancy JS, Abbattista A, Martini JF, Chen J, Peltz G, Thurm H, Ou SI, Shaw AT
Lancet Oncol 2018 Dec;19(12):1654-1667. Epub 2018 Nov 6 doi: 10.1016/S1470-2045(18)30649-1. PMID: 30413378

Diagnosis

Davis JL, Al-Ibraheemi A, Rudzinski ER, Surrey LF
Histopathology 2022 Jan;80(1):4-18. doi: 10.1111/his.14443. PMID: 34958503
Golding B, Luu A, Jones R, Viloria-Petit AM
Mol Cancer 2018 Feb 19;17(1):52. doi: 10.1186/s12943-018-0810-4. PMID: 29455675Free PMC Article
Cerrato A, Merolla F, Morra F, Celetti A
Int J Cancer 2018 Apr 1;142(7):1300-1308. Epub 2017 Oct 26 doi: 10.1002/ijc.31106. PMID: 29044514
Shaw AT, Felip E, Bauer TM, Besse B, Navarro A, Postel-Vinay S, Gainor JF, Johnson M, Dietrich J, James LP, Clancy JS, Chen J, Martini JF, Abbattista A, Solomon BJ
Lancet Oncol 2017 Dec;18(12):1590-1599. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30680-0. PMID: 29074098Free PMC Article
Weiss JM, Stinchcombe TE
Oncologist 2013;18(8):947-53. Epub 2013 Aug 5 doi: 10.1634/theoncologist.2013-0096. PMID: 23918070Free PMC Article

Therapy

Mizuta H, Okada K, Araki M, Adachi J, Takemoto A, Kutkowska J, Maruyama K, Yanagitani N, Oh-Hara T, Watanabe K, Tamai K, Friboulet L, Katayama K, Ma B, Sasakura Y, Sagae Y, Kukimoto-Niino M, Shirouzu M, Takagi S, Simizu S, Nishio M, Okuno Y, Fujita N, Katayama R
Nat Commun 2021 Feb 24;12(1):1261. doi: 10.1038/s41467-021-21396-w. PMID: 33627640Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Du X, Shao Y, Qin HF, Tai YH, Gao HJ
Thorac Cancer 2018 Apr;9(4):423-430. Epub 2018 Feb 28 doi: 10.1111/1759-7714.12613. PMID: 29488330Free PMC Article
Du Z, Lovly CM
Mol Cancer 2018 Feb 19;17(1):58. doi: 10.1186/s12943-018-0782-4. PMID: 29455648Free PMC Article
Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ
N Engl J Med 2014 Nov 20;371(21):1963-71. Epub 2014 Sep 27 doi: 10.1056/NEJMoa1406766. PMID: 25264305Free PMC Article

Prognosis

Pellerino A, Bruno F, Rudà R, Soffietti R
Curr Treat Options Oncol 2021 Oct 25;22(12):110. doi: 10.1007/s11864-021-00911-7. PMID: 34693454
Shi Y, Lei Y, Liu L, Zhang S, Wang W, Zhao J, Zhao S, Dong X, Yao M, Wang K, Zhou Q
Cancer Med 2021 Apr;10(7):2216-2231. Epub 2021 Mar 2 doi: 10.1002/cam4.3649. PMID: 33655698Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Frost N, Zhamurashvili T, von Laffert M, Klauschen F, Ruwwe-Glösenkamp C, Raspe M, Brunn M, Ochsenreither S, Temmesfeld-Wollbrück B, Suttorp N, Grohé C, Witzenrath M
Clin Lung Cancer 2020 Nov;21(6):e607-e621. Epub 2020 May 22 doi: 10.1016/j.cllc.2020.05.014. PMID: 32620471
Shaw AT, Felip E, Bauer TM, Besse B, Navarro A, Postel-Vinay S, Gainor JF, Johnson M, Dietrich J, James LP, Clancy JS, Chen J, Martini JF, Abbattista A, Solomon BJ
Lancet Oncol 2017 Dec;18(12):1590-1599. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30680-0. PMID: 29074098Free PMC Article

Clinical prediction guides

Shi Y, Lei Y, Liu L, Zhang S, Wang W, Zhao J, Zhao S, Dong X, Yao M, Wang K, Zhou Q
Cancer Med 2021 Apr;10(7):2216-2231. Epub 2021 Mar 2 doi: 10.1002/cam4.3649. PMID: 33655698Free PMC Article
Mizuta H, Okada K, Araki M, Adachi J, Takemoto A, Kutkowska J, Maruyama K, Yanagitani N, Oh-Hara T, Watanabe K, Tamai K, Friboulet L, Katayama K, Ma B, Sasakura Y, Sagae Y, Kukimoto-Niino M, Shirouzu M, Takagi S, Simizu S, Nishio M, Okuno Y, Fujita N, Katayama R
Nat Commun 2021 Feb 24;12(1):1261. doi: 10.1038/s41467-021-21396-w. PMID: 33627640Free PMC Article
Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, Riely GJ, Tan EH, Seto T, James LP, Clancy JS, Abbattista A, Martini JF, Chen J, Peltz G, Thurm H, Ou SI, Shaw AT
Lancet Oncol 2018 Dec;19(12):1654-1667. Epub 2018 Nov 6 doi: 10.1016/S1470-2045(18)30649-1. PMID: 30413378
Drilon A, Hu ZI, Lai GGY, Tan DSW
Nat Rev Clin Oncol 2018 Mar;15(3):151-167. Epub 2017 Nov 14 doi: 10.1038/nrclinonc.2017.175. PMID: 29134959Free PMC Article
Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ
N Engl J Med 2014 Nov 20;371(21):1963-71. Epub 2014 Sep 27 doi: 10.1056/NEJMoa1406766. PMID: 25264305Free PMC Article

Recent systematic reviews

White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Zhu VW, Zhao JJ, Gao Y, Syn NL, Zhang SS, Ou SI, Bauer KA, Nagasaka M
Lung Cancer 2021 Jul;157:147-155. Epub 2021 May 20 doi: 10.1016/j.lungcan.2021.05.019. PMID: 34049720
Li G, Dai WR, Shao FC
Eur Rev Med Pharmacol Sci 2017 Aug;21(15):3496-3503. PMID: 28829490
Ma H, Yao WX, Huang L, Jin SH, Liu DH, Liu Y, Tian X, Tian JH, Zhou JG
Oncotarget 2016 Oct 25;7(43):70128-70142. doi: 10.18632/oncotarget.11806. PMID: 27602773Free PMC Article
Pyo JS, Kang G, Sohn JH
Int J Biol Markers 2016 Dec 23;31(4):e413-e421. doi: 10.5301/jbm.5000218. PMID: 27338643

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