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Myopia 6(MYP6)

MedGen UID:
324696
•Concept ID:
C1837148
•
Disease or Syndrome
Synonyms: Myopia, susceptibility to; MYP6
 
Gene (location): SCO2 (22q13.33)
 
Monarch Initiative: MONDO:0012154
OMIM®: 608908

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. [from OMIM]

Clinical features

From HPO
High myopia
MedGen UID:
78759
•Concept ID:
C0271183
•
Disease or Syndrome
A severe form of myopia with greater than -6.00 diopters.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Primary retinopexy in preventing retinal detachment in a tertiary eye hospital: a study of 1157 eyes.
Moussa G, Samia-Aly E, Ch'ng SW, Lett KS, Mitra A, Tyagi AK, Sharma A, Andreatta W
Eye (Lond) 2022 May;36(5):1080-1085. Epub 2021 May 25 doi: 10.1038/s41433-021-01581-3. PMID: 34035492Free PMC Article
Choice of Primary Rhegmatogenous Retinal Detachment Repair Method in US Commercially Insured and Medicare Advantage Patients, 2003-2016.
Reeves MG, Pershing S, Afshar AR
Am J Ophthalmol 2018 Dec;196:82-90. Epub 2018 Aug 23 doi: 10.1016/j.ajo.2018.08.024. PMID: 30144442
Visual quality of Q-value-guided LASIK in the treatment of high myopia.
Zheng H, Song L
Eye Sci 2011 Dec;26(4):208-10, 216. doi: 10.3969/j.issn.1000-4432.2011.04.005. PMID: 22187304

Recent clinical studies

Etiology

IMI-Management and Investigation of High Myopia in Infants and Young Children.
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Changes in retinal vascular bifurcation in eyes with myopia.
Sun C, Chen T, Cong J, Wu X, Wang J, Yuan Y
BMC Ophthalmol 2022 Oct 21;22(1):408. doi: 10.1186/s12886-022-02629-y. PMID: 36271390Free PMC Article
Monochromatic higher order aberrations in highly myopic eyes with Staphyloma.
Delgado-Tirado S, López-Miguel A, Báez-Peralta Y, González-Buendía L, Fernández I, Alió JL, Maldonado MJ, Coco-Martín RM
BMC Ophthalmol 2021 May 18;21(1):223. doi: 10.1186/s12886-021-01965-9. PMID: 34006229Free PMC Article
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Study of the relationship between myopia and personality.
Rodríguez Uña I, Pérez Bartolomé F, Urriés Ortiz M, Arriola Villalobos P, Bermúdez Vallecilla M, Fernández-Vega Cueto L, Martín Villaescusa C, Marticorena Álvarez P
Arch Soc Esp Oftalmol 2015 Aug;90(8):365-72. Epub 2015 Mar 24 doi: 10.1016/j.oftal.2015.01.005. PMID: 25817967

Diagnosis

Prevalence and associated factors of myopia in children and adolescents in Russia: the Ural Children Eye Study.
Bikbov MM, Kazakbaeva GM, Fakhretdinova AA, Tuliakova AM, Iakupova EM, Panda-Jonas S, Gilemzianova LI, Garipova LA, Khakimov DA, Islamova LI, Jonas JB
Br J Ophthalmol 2024 Mar 20;108(4):593-598. doi: 10.1136/bjo-2022-322945. PMID: 37019624
IMI-Management and Investigation of High Myopia in Infants and Young Children.
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Prevalence and related factors of myopic retinopathy - a hospital-based cross-section study in Vietnam.
Nguyen HTT, Hoang TT, Pham CM, Nguyen TM, Dang TM, Fricke TR
Clin Exp Optom 2023 May;106(4):427-430. Epub 2022 Feb 20 doi: 10.1080/08164622.2022.2039555. PMID: 35188078
Predictors of Pseudophakic Retinal Tears at a Tertiary Care Academic Medical Center.
Fonteh CN, Patnaik JL, Grove NC, Lynch AM, Christopher KL
Ophthalmol Retina 2022 Jun;6(6):450-456. Epub 2022 Jan 31 doi: 10.1016/j.oret.2022.01.010. PMID: 35093584
Optical Coherence Tomography Angiography of Choroidal Neovascularization Secondary to Pathologic Myopia.
Querques G, Corvi F, Querques L, Souied EH, Bandello F
Dev Ophthalmol 2016;56:101-6. Epub 2016 Mar 15 doi: 10.1159/000442800. PMID: 27023343

Therapy

Clinical Evaluation of MyoCare in Europe (CEME): study protocol for a prospective, multicenter, randomized, double-blinded, and controlled clinical trial.
Alvarez-Peregrina C, Sanchez-Tena MA, Martinez-Perez C, Villa-Collar C; Clinical Evaluation of MyoCare in Europe –the CEME Study Group, Ohlendorf A
Trials 2023 Oct 17;24(1):674. doi: 10.1186/s13063-023-07696-0. PMID: 37848908Free PMC Article
Evolution of the Prevalence of Myopia among Taiwanese Schoolchildren: A Review of Survey Data from 1983 through 2017.
Tsai TH, Liu YL, Ma IH, Su CC, Lin CW, Lin LL, Hsiao CK, Wang IJ
Ophthalmology 2021 Feb;128(2):290-301. Epub 2020 Jul 15 doi: 10.1016/j.ophtha.2020.07.017. PMID: 32679159
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Influence of the extent of myopia on the progression of normal-tension glaucoma.
Sohn SW, Song JS, Kee C
Am J Ophthalmol 2010 May;149(5):831-8. Epub 2010 Mar 15 doi: 10.1016/j.ajo.2009.12.033. PMID: 20231010
A critical evaluation of the evidence supporting the practice of behavioural vision therapy.
Barrett BT
Ophthalmic Physiol Opt 2009 Jan;29(1):4-25. doi: 10.1111/j.1475-1313.2008.00607.x. PMID: 19154276

Prognosis

Predictors of Pseudophakic Retinal Tears at a Tertiary Care Academic Medical Center.
Fonteh CN, Patnaik JL, Grove NC, Lynch AM, Christopher KL
Ophthalmol Retina 2022 Jun;6(6):450-456. Epub 2022 Jan 31 doi: 10.1016/j.oret.2022.01.010. PMID: 35093584
Association Between Hay Fever and High Myopia in United States Adolescents and Adults.
Shafer BM, Qiu M, Rapuano CJ, Shields CL
Eye Contact Lens 2017 May;43(3):186-191. doi: 10.1097/ICL.0000000000000251. PMID: 26974535
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Myopia and Cognitive Performance: Results From the Gutenberg Health Study.
Mirshahi A, Ponto KA, Laubert-Reh D, Rahm B, Lackner KJ, Binder H, Pfeiffer N, Unterrainer JM
Invest Ophthalmol Vis Sci 2016 Oct 1;57(13):5230-5236. doi: 10.1167/iovs.16-19507. PMID: 27701634
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Changes in retinal vascular bifurcation in eyes with myopia.
Sun C, Chen T, Cong J, Wu X, Wang J, Yuan Y
BMC Ophthalmol 2022 Oct 21;22(1):408. doi: 10.1186/s12886-022-02629-y. PMID: 36271390Free PMC Article
Monochromatic higher order aberrations in highly myopic eyes with Staphyloma.
Delgado-Tirado S, López-Miguel A, Báez-Peralta Y, González-Buendía L, Fernández I, Alió JL, Maldonado MJ, Coco-Martín RM
BMC Ophthalmol 2021 May 18;21(1):223. doi: 10.1186/s12886-021-01965-9. PMID: 34006229Free PMC Article
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Study of the relationship between myopia and personality.
Rodríguez Uña I, Pérez Bartolomé F, Urriés Ortiz M, Arriola Villalobos P, Bermúdez Vallecilla M, Fernández-Vega Cueto L, Martín Villaescusa C, Marticorena Álvarez P
Arch Soc Esp Oftalmol 2015 Aug;90(8):365-72. Epub 2015 Mar 24 doi: 10.1016/j.oftal.2015.01.005. PMID: 25817967
Regulation of scleral metabolism in myopia and the role of transforming growth factor-beta.
McBrien NA
Exp Eye Res 2013 Sep;114:128-40. Epub 2013 Feb 8 doi: 10.1016/j.exer.2013.01.014. PMID: 23399866

Recent systematic reviews

Duration of topical steroid application after photorefractive keratectomy with mitomycin C.
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpour E, Aghamirsalim M, Seyedian MA, Hashemi H
J Cataract Refract Surg 2020 Apr;46(4):622-632. doi: 10.1097/j.jcrs.0000000000000060. PMID: 32271298
Do findings on routine examination identify patients at risk for primary open-angle glaucoma? The rational clinical examination systematic review.
Hollands H, Johnson D, Hollands S, Simel DL, Jinapriya D, Sharma S
JAMA 2013 May 15;309(19):2035-42. doi: 10.1001/jama.2013.5099. PMID: 23677315

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      Clinical tests in GTR
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      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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