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Legionnaire disease, susceptibility to

MedGen UID:
325276
Concept ID:
C1837872
Finding
Synonym: LEGIONNAIRE DISEASE, SUSCEPTIBILITY TO
 
Gene (location): TLR5 (1q41)
 
Monarch Initiative: MONDO:0012057
OMIM®: 608556

Definition

Legionnaire disease (LD) is a type of pneumonia caused by Legionella pneumophila, a flagellated gram-negative bacterium found primarily in warm water environments. The disease and the bacterium were discovered following an outbreak traced to a 1976 American Legion convention in Philadelphia. A number of risk factors for acquiring LD have been identified, including age, smoking, chronic lung disease, cancer, and immunosuppression (summary by Hawn et al., 2003). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Guillemot J, Ginevra C, Allam C, Kay E, Gilbert C, Doublet P, Jarraud S, Chapalain A
Virulence 2022 Dec;13(1):160-173. doi: 10.1080/21505594.2021.2022861. PMID: 35030980Free PMC Article
Phin N, Parry-Ford F, Harrison T, Stagg HR, Zhang N, Kumar K, Lortholary O, Zumla A, Abubakar I
Lancet Infect Dis 2014 Oct;14(10):1011-21. Epub 2014 Jun 23 doi: 10.1016/S1473-3099(14)70713-3. PMID: 24970283
Roig J, Carreres A, Domingo C
Drugs 1993 Jul;46(1):63-79. doi: 10.2165/00003495-199346010-00005. PMID: 7691508

Recent clinical studies

Etiology

Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686
Halperin JJ
Infect Dis Clin North Am 2017 Mar;31(1):55-68. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.005. PMID: 27979685
Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463
Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877
Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390

Diagnosis

Dunne WM Jr, Picot N, van Belkum A
Infect Dis Clin North Am 2017 Mar;31(1):167-178. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.012. PMID: 27979684
Agarwal S, Abell V, File TM Jr
Infect Dis Clin North Am 2017 Mar;31(1):155-165. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.011. PMID: 27979683
Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463
Phin N, Parry-Ford F, Harrison T, Stagg HR, Zhang N, Kumar K, Lortholary O, Zumla A, Abubakar I
Lancet Infect Dis 2014 Oct;14(10):1011-21. Epub 2014 Jun 23 doi: 10.1016/S1473-3099(14)70713-3. PMID: 24970283
Stout JE, Yu VL
Curr Opin Infect Dis 2003 Aug;16(4):337-41. doi: 10.1097/00001432-200308000-00005. PMID: 12861086

Therapy

Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686
Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463
Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877
Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390
Roig J, Carreres A, Domingo C
Drugs 1993 Jul;46(1):63-79. doi: 10.2165/00003495-199346010-00005. PMID: 7691508

Prognosis

Deecker SR, Urbanus ML, Nicholson B, Ensminger AW
Appl Environ Microbiol 2021 Aug 11;87(17):e0046721. doi: 10.1128/AEM.00467-21. PMID: 34132590Free PMC Article
Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463
Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877
Vanfleteren LE, Linssen CF
Curr Opin Pulm Med 2010 Sep;16(5):489-95. doi: 10.1097/MCP.0b013e32833b1c54. PMID: 20592601
Roig J, Carreres A, Domingo C
Drugs 1993 Jul;46(1):63-79. doi: 10.2165/00003495-199346010-00005. PMID: 7691508

Clinical prediction guides

Deecker SR, Urbanus ML, Nicholson B, Ensminger AW
Appl Environ Microbiol 2021 Aug 11;87(17):e0046721. doi: 10.1128/AEM.00467-21. PMID: 34132590Free PMC Article
Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877
Breiman RF, Butler JC
Semin Respir Infect 1998 Jun;13(2):84-9. PMID: 9643385
Roig J, Carreres A, Domingo C
Drugs 1993 Jul;46(1):63-79. doi: 10.2165/00003495-199346010-00005. PMID: 7691508
Friedman H, Klein TW, Widen R, Newton C, Blanchard DK, Yamamoto Y
Adv Exp Med Biol 1988;239:327-41. doi: 10.1007/978-1-4757-5421-6_32. PMID: 3059772

Recent systematic reviews

Pappa O, Chochlakis D, Sandalakis V, Dioli C, Psaroulaki A, Mavridou A
Int J Environ Res Public Health 2020 Aug 11;17(16) doi: 10.3390/ijerph17165809. PMID: 32796666Free PMC Article

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