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Impacted teeth, multiple

MedGen UID:
327004
Concept ID:
C1839965
Finding
Synonym: IMPACTED TEETH, MULTIPLE
 
HPO: HP:0001571
Monarch Initiative: MONDO:0010629
OMIM®: 308280

Definition

The presence of multiple impacted teeth. [from HPO]

Clinical features

From HPO
Teeth, supernumerary
MedGen UID:
21210
Concept ID:
C0040457
Anatomical Abnormality
The presence of one or more teeth additional to the normal number.
Impacted teeth, multiple
MedGen UID:
327004
Concept ID:
C1839965
Finding
The presence of multiple impacted teeth.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpacted teeth, multiple

Conditions with this feature

Fibrous dysplasia of jaw
MedGen UID:
40219
Concept ID:
C0008029
Disease or Syndrome
Cherubism is a childhood-onset, autoinflammatory bone disease characterized by bilateral and symmetric proliferative fibroosseous lesions limited to the mandible and maxilla. The enlargement is usually symmetric in nature. The phenotype ranges from no clinical manifestations to severe mandibular and maxillary overgrowth with respiratory, vision, speech, and swallowing problems. In most affected persons, teeth are displaced, unerupted, unformed, or absent, or may appear to be floating in cystlike spaces; malocclusion, premature exfoliation of deciduous teeth, and root resorption have also been reported. The course and duration of the active process of bone destruction varies between affected individuals; the onset is usually in early childhood, and typically new lesions can occur until puberty. Regression of the lesions occurs as they become filled with bone and remodel during the second and third decade of life. By age 30 years, the facial abnormalities associated with cherubism are not usually recognizable and residual deformity of the jaws is rare. Typically, cherubism is an isolated benign condition; the affected person has normal intellectual skills and is without other physical anomalies.
Oto-palato-digital syndrome, type I
MedGen UID:
78542
Concept ID:
C0265251
Disease or Syndrome
The X-linked otopalatodigital (X-OPD) spectrum disorders, characterized primarily by skeletal dysplasia, include the following: Otopalatodigital syndrome type 1 (OPD1). Otopalatodigital syndrome type 2 (OPD2). Frontometaphyseal dysplasia type 1 (FMD1). Melnick-Needles syndrome (MNS). Terminal osseous dysplasia with pigmentary skin defects (TODPD). In OPD1, most manifestations are present at birth; females can present with severity similar to affected males, although some have only mild manifestations. In OPD2, females are less severely affected than related affected males. Most males with OPD2 die during the first year of life, usually from thoracic hypoplasia resulting in pulmonary insufficiency. Males who live beyond the first year of life are usually developmentally delayed and require respiratory support and assistance with feeding. In FMD1, females are less severely affected than related affected males. Males do not experience a progressive skeletal dysplasia but may have joint contractures and hand and foot malformations. Progressive scoliosis is observed in both affected males and females. In MNS, wide phenotypic variability is observed; some individuals are diagnosed in adulthood, while others require respiratory support and have reduced longevity. MNS in males results in perinatal lethality in all recorded cases. TODPD, seen only in females, is characterized by a skeletal dysplasia that is most prominent in the digits, pigmentary defects of the skin, and recurrent digital fibromata.
Elsahy-Waters syndrome
MedGen UID:
923028
Concept ID:
C0809936
Disease or Syndrome
The core phenotype of Elsahy-Waters syndrome consists of brachycephaly, facial asymmetry, marked hypertelorism, proptosis, blepharochalasis, midface hypoplasia, broad nose with concave nasal ridge, and prognathism; radicular dentin dysplasia with consequent obliterated pulp chambers, apical translucent cysts, recurrent infections, and early loss of teeth; vertebral fusions, particularly at C2-C3; and moderate mental retardation. Skin wrinkling over the glabellar region seems common, and in males, hypospadias has always been present. Inter- and intrafamilial variability has been reported regarding the presence of vertebral fusions, hearing loss, and dentigerous cysts. Midface hypoplasia, facial asymmetry, progressive dental anomalies, and impaired cognitive development become more evident in adulthood (summary by Castori et al., 2010).
Eiken syndrome
MedGen UID:
325097
Concept ID:
C1838779
Congenital Abnormality
Eiken syndrome (EKNS) is an autosomal recessive skeletal dysplasia characterized by delayed ossification of bones, epiphyseal dysplasia, and bone remodeling abnormalities. Type A1 brachydactyly (see 112500), supernumerary epiphyses of proximal phalanges and metacarpals, and failure of eruption of primary teeth have also been described. Defining radiologic features include delayed ossification of epiphyses and primary ossification centers of short tubular bones, modeling abnormalities of tubular bones, and angel-shaped phalanges (Jacob et al., 2019). See 603740 for a disorder with similar radiologic features.
Impacted teeth, multiple
MedGen UID:
327004
Concept ID:
C1839965
Finding
The presence of multiple impacted teeth.
Brachydactyly type E1
MedGen UID:
396291
Concept ID:
C1862102
Finding
Any brachydactyly type E in which the cause of the disease is a mutation in the HOXD13 gene.
Gigantiform cementoma
MedGen UID:
501159
Concept ID:
C3495361
Neoplastic Process
Familial gigantiform cementoma (FGC) is a rare autosomal dominant tumor that is benign but can result in disfigurement of the facial skeleton. Onset of symptoms usually occurs in adolescence, with rapid growth causing expansion of the maxilla and mandible, resulting in significant facial deformity and malocclusion. Radiologic examination defines 3 stages of the lesions: osteolytic, with well-defined radiolucent areas; cementoblastic, in which cementum is formed within the fibrous tissue, represented by radiopacities within the radiolucent zones; and mature, in which the fibrous tissue is almost completely replaced by cementum, represented by a large radioopaque area surrounded by a radiolucent space separating the tumor from normal bone. Histologic examination shows confluent sclerotic avascular cementum, with distinct areas of lamellar bone in some cases. Examination under polarized light reveals a varied birefringent pattern typical of cementum (summary by Finical et al., 1999). Affected individuals may develop osteopenia and sustain long bone fractures after minor trauma (Moshref et al., 2008; Wang et al., 2015).

Professional guidelines

PubMed

Pan W, Yu L, Chen S, Zhou J, Chi J, Voliere G, Du W, Gong Y, Lin H, Hu R
Am J Orthod Dentofacial Orthop 2023 Dec;164(6):783-792. Epub 2023 Jul 26 doi: 10.1016/j.ajodo.2023.05.027. PMID: 37498252

Recent clinical studies

Etiology

Du W, Chi J, He S, Wu G, Pan W, Wang Y, Voliere G, Hu R
Am J Orthod Dentofacial Orthop 2022 Dec;162(6):907-916. Epub 2022 Sep 16 doi: 10.1016/j.ajodo.2021.07.028. PMID: 36123228
Kiencało A, Jamka-Kasprzyk M, Panaś M, Wyszyńska-Pawelec G
Dent Med Probl 2021 Jan-Mar;58(1):75-80. doi: 10.17219/dmp/127028. PMID: 33789003
Synan W, Stein K
Oral Maxillofac Surg Clin North Am 2020 Nov;32(4):519-559. Epub 2020 Sep 9 doi: 10.1016/j.coms.2020.07.002. PMID: 32919832
Chen KC, Huang JS, Chen MY, Cheng KH, Wong TY, Huang TT
J Oral Maxillofac Surg 2019 May;77(5):920-931. Epub 2018 Dec 27 doi: 10.1016/j.joms.2018.12.014. PMID: 30682325
Phillips C, White RP Jr
J Oral Maxillofac Surg 2012 Sep;70(9 Suppl 1):S11-4. Epub 2012 Jun 16 doi: 10.1016/j.joms.2012.04.024. PMID: 22705213

Diagnosis

Zhu J, Chen Z, Zhao J, Yu Y, Li X, Shi K, Zhang F, Yu F, Shi K, Sun Z, Lin N, Zheng Y
BMC Oral Health 2023 Jun 3;23(1):358. doi: 10.1186/s12903-023-03027-6. PMID: 37270488Free PMC Article
Ono S, Hirose K, Sukegawa S, Nakamura S, Motooka D, Iwamoto Y, Hori Y, Oya K, Fukuda Y, Toyosawa S
Diagn Pathol 2022 Oct 14;17(1):82. doi: 10.1186/s13000-022-01261-0. PMID: 36242048Free PMC Article
Synan W, Stein K
Oral Maxillofac Surg Clin North Am 2020 Nov;32(4):519-559. Epub 2020 Sep 9 doi: 10.1016/j.coms.2020.07.002. PMID: 32919832
Chen KC, Huang JS, Chen MY, Cheng KH, Wong TY, Huang TT
J Oral Maxillofac Surg 2019 May;77(5):920-931. Epub 2018 Dec 27 doi: 10.1016/j.joms.2018.12.014. PMID: 30682325
Cammarata-Scalisi F, Avendaño A, Callea M
Arch Argent Pediatr 2018 Dec 1;116(6):437-444. doi: 10.5546/aap.2018.eng.437. PMID: 30457727

Therapy

Lu Z, Bingquan H, Jun T, Fei G
Int Wound J 2024 Jan;21(1):e14651. doi: 10.1111/iwj.14651. PMID: 38272792Free PMC Article
Tsai KZ, Huang RY, Cheng WC, Han CL, Huang WC, Sui X, Lavie CJ, Lin GM
Am J Hypertens 2023 Feb 13;36(2):102-108. doi: 10.1093/ajh/hpac119. PMID: 36270011
Hadad H, Santos AFP, de Jesus LK, Poli PP, Mariano RC, Theodoro LH, Maiorana C, Souza FÁ
J Oral Maxillofac Surg 2022 Jan;80(1):37.e1-37.e12. Epub 2021 Sep 6 doi: 10.1016/j.joms.2021.08.267. PMID: 34656515
Defne YY, Ilknur E, Melike K, Simeyya B, Fatmanur K, Yener U
Niger J Clin Pract 2021 Apr;24(4):483-488. doi: 10.4103/njcp.njcp_262_20. PMID: 33851668
Kiencało A, Jamka-Kasprzyk M, Panaś M, Wyszyńska-Pawelec G
Dent Med Probl 2021 Jan-Mar;58(1):75-80. doi: 10.17219/dmp/127028. PMID: 33789003

Prognosis

Nishimoto RN, Moshman AT, Dodson TB, Beirne OR
J Oral Maxillofac Surg 2020 Nov;78(11):1886-1891. Epub 2020 Jun 11 doi: 10.1016/j.joms.2020.05.046. PMID: 32640205
Alqerban A, Storms AS, Voet M, Fieuws S, Willems G
Dentomaxillofac Radiol 2016;45(3):20150232. Epub 2015 Dec 18 doi: 10.1259/dmfr.20150232. PMID: 26683426Free PMC Article
Carter K, Worthington S
J Dent Res 2016 Mar;95(3):267-76. Epub 2015 Nov 11 doi: 10.1177/0022034515615857. PMID: 26561441
Rallan M, Rallan NS, Goswami M, Rawat K
BMJ Case Rep 2013 May 22;2013 doi: 10.1136/bcr-2013-009995. PMID: 23704467Free PMC Article
Phillips C, White RP Jr
J Oral Maxillofac Surg 2012 Sep;70(9 Suppl 1):S11-4. Epub 2012 Jun 16 doi: 10.1016/j.joms.2012.04.024. PMID: 22705213

Clinical prediction guides

Kiencało A, Jamka-Kasprzyk M, Panaś M, Wyszyńska-Pawelec G
Dent Med Probl 2021 Jan-Mar;58(1):75-80. doi: 10.17219/dmp/127028. PMID: 33789003
Nishimoto RN, Moshman AT, Dodson TB, Beirne OR
J Oral Maxillofac Surg 2020 Nov;78(11):1886-1891. Epub 2020 Jun 11 doi: 10.1016/j.joms.2020.05.046. PMID: 32640205
Alqerban A, Storms AS, Voet M, Fieuws S, Willems G
Dentomaxillofac Radiol 2016;45(3):20150232. Epub 2015 Dec 18 doi: 10.1259/dmfr.20150232. PMID: 26683426Free PMC Article
Carter K, Worthington S
J Dent Res 2016 Mar;95(3):267-76. Epub 2015 Nov 11 doi: 10.1177/0022034515615857. PMID: 26561441
Phillips C, White RP Jr
J Oral Maxillofac Surg 2012 Sep;70(9 Suppl 1):S11-4. Epub 2012 Jun 16 doi: 10.1016/j.joms.2012.04.024. PMID: 22705213

Recent systematic reviews

Carter K, Worthington S
J Dent Res 2016 Mar;95(3):267-76. Epub 2015 Nov 11 doi: 10.1177/0022034515615857. PMID: 26561441
Kalantar Motamedi MR, Heidarpour M, Siadat S, Kalantar Motamedi A, Bahreman AA
J Oral Maxillofac Surg 2015 Sep;73(9):1672-85. Epub 2015 Mar 24 doi: 10.1016/j.joms.2015.03.031. PMID: 25882437

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