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Early Favorable Non-Hodgkin Lymphoma

MedGen UID:
328321
•Concept ID:
C1711314
•
Neoplastic Process
Synonym: Early Favorable Non-Hodgkin's Lymphoma

Definition

A clinical stage I or II non-Hodgkin lymphoma without any of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Favorable Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Challenges and Opportunities in the Management of Diffuse Large B-Cell Lymphoma in Older Patients.
Di M, Huntington SF, Olszewski AJ
Oncologist 2021 Feb;26(2):120-132. Epub 2020 Dec 9 doi: 10.1002/onco.13610. PMID: 33230948Free PMC Article
Early Progression of Follicular Lymphoma: Biology and Treatment.
Lipof JJ, Barr PM
Hematol Oncol Clin North Am 2020 Aug;34(4):757-769. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.009. PMID: 32586579
Treatment of patch-stage mycosis fungoides with topical corticosteroids.
Zackheim HS
Dermatol Ther 2003;16(4):283-7. doi: 10.1111/j.1396-0296.2003.01639.x. PMID: 14686970

Recent clinical studies

Etiology

ROSEWOOD: A Phase II Randomized Study of Zanubrutinib Plus Obinutuzumab Versus Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma.
Zinzani PL, Mayer J, Flowers CR, Bijou F, De Oliveira AC, Song Y, Zhang Q, Merli M, Bouabdallah K, Ganly P, Zhang H, Johnson R, Martín García-Sancho A, Provencio Pulla M, Trněný M, Yuen S, Tilly H, Kingsley E, Tumyan G, Assouline SE, Auer R, Ivanova E, Kim P, Huang S, Delarue R, Trotman J
J Clin Oncol 2023 Nov 20;41(33):5107-5117. Epub 2023 Jul 28 doi: 10.1200/JCO.23.00775. PMID: 37506346
Challenges and Opportunities in the Management of Diffuse Large B-Cell Lymphoma in Older Patients.
Di M, Huntington SF, Olszewski AJ
Oncologist 2021 Feb;26(2):120-132. Epub 2020 Dec 9 doi: 10.1002/onco.13610. PMID: 33230948Free PMC Article
Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias.
Fogarty H, Dowling A, O'Brien D, Langabeer S, Bacon CL, Flavin R, O'Dwyer M, Hennessy B, O'Leary H, Crotty G, Henderson R, Nolan J, Thornton P, Vandenberghe E, Quinn F
Ir J Med Sci 2021 Aug;190(3):1087-1094. Epub 2020 Oct 17 doi: 10.1007/s11845-020-02386-1. PMID: 33068240
Refining patient selection for CAR T-cell therapy in aggressive large B-cell lymphoma.
Cahill KE, Leukam MJ, Riedell PA
Leuk Lymphoma 2020 Apr;61(4):799-807. Epub 2019 Nov 21 doi: 10.1080/10428194.2019.1691201. PMID: 31750749
Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert A, Plütschow A, Eich HT, Lohri A, Dörken B, Borchmann P, Berger B, Greil R, Willborn KC, Wilhelm M, Debus J, Eble MJ, Sökler M, Ho A, Rank A, Ganser A, Trümper L, Bokemeyer C, Kirchner H, Schubert J, Král Z, Fuchs M, Müller-Hermelink HK, Müller RP, Diehl V
N Engl J Med 2010 Aug 12;363(7):640-52. doi: 10.1056/NEJMoa1000067. PMID: 20818855

Diagnosis

Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma.
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Duodenal Follicular Lymphoma: Track or Treat?
Varanese M, Lauro A, Lattina I, Tripodi D, Daralioti T, Khouzam S, Marino IR, Stigliano V, D'Andrea V, Frattaroli S, Sorrenti S
Dig Dis Sci 2022 May;67(5):1733-1738. Epub 2022 Apr 8 doi: 10.1007/s10620-022-07498-5. PMID: 35394594
Diffuse Large B-cell Lymphoma Presenting as Peritoneal Lymphomatosis: A Case Report and Literature Review.
Ichikawa S, Fukuhara N, Saito K, Onodera K, Onishi Y, Yokoyama H, Ichinohasama R, Harigae H
Intern Med 2022 Jul 1;61(13):2057-2060. Epub 2021 Dec 11 doi: 10.2169/internalmedicine.8793-21. PMID: 34897156Free PMC Article
Challenges and Opportunities in the Management of Diffuse Large B-Cell Lymphoma in Older Patients.
Di M, Huntington SF, Olszewski AJ
Oncologist 2021 Feb;26(2):120-132. Epub 2020 Dec 9 doi: 10.1002/onco.13610. PMID: 33230948Free PMC Article
Hodgkin's disease: management of first relapse.
Yuen AR, Horning SJ
Oncology (Williston Park) 1996 Feb;10(2):233-40, 245; discussion 245-6, 249-. PMID: 8838268

Therapy

Cardiotoxicity of BTK inhibitors: ibrutinib and beyond.
Christensen BW, Zaha VG, Awan FT
Expert Rev Hematol 2022 Apr;15(4):321-331. Epub 2022 Apr 22 doi: 10.1080/17474086.2022.2067526. PMID: 35437106
Duodenal Follicular Lymphoma: Track or Treat?
Varanese M, Lauro A, Lattina I, Tripodi D, Daralioti T, Khouzam S, Marino IR, Stigliano V, D'Andrea V, Frattaroli S, Sorrenti S
Dig Dis Sci 2022 May;67(5):1733-1738. Epub 2022 Apr 8 doi: 10.1007/s10620-022-07498-5. PMID: 35394594
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Challenges and Opportunities in the Management of Diffuse Large B-Cell Lymphoma in Older Patients.
Di M, Huntington SF, Olszewski AJ
Oncologist 2021 Feb;26(2):120-132. Epub 2020 Dec 9 doi: 10.1002/onco.13610. PMID: 33230948Free PMC Article
Thrombocytopenia and fever: not just another infection….
Sriskandarajah P, Davies R
BMJ Case Rep 2016 May 12;2016 doi: 10.1136/bcr-2016-214669. PMID: 27174453Free PMC Article

Prognosis

Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Motamedi M, Xiao MZX, Deschenes J, Hardin J, Sterrett R, Street L, Taparia M, Mahe E, Ferrara G, Barrie JR, Gniadecki R
Dermatology 2024;240(3):468-473. Epub 2024 Feb 29 doi: 10.1159/000537893. PMID: 38422999
Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma.
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Duodenal Follicular Lymphoma: Track or Treat?
Varanese M, Lauro A, Lattina I, Tripodi D, Daralioti T, Khouzam S, Marino IR, Stigliano V, D'Andrea V, Frattaroli S, Sorrenti S
Dig Dis Sci 2022 May;67(5):1733-1738. Epub 2022 Apr 8 doi: 10.1007/s10620-022-07498-5. PMID: 35394594
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Hodgkin's disease: management of first relapse.
Yuen AR, Horning SJ
Oncology (Williston Park) 1996 Feb;10(2):233-40, 245; discussion 245-6, 249-. PMID: 8838268

Clinical prediction guides

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Phase II NIVAHL Trial.
Bröckelmann PJ, Bühnen I, Meissner J, Trautmann-Grill K, Herhaus P, Halbsguth TV, Schaub V, Kerkhoff A, Mathas S, Bormann M, Dickhut A, Kaul H, Fuchs M, Kobe C, Baues C, Borchmann P, Engert A, von Tresckow B
J Clin Oncol 2023 Feb 20;41(6):1193-1199. Epub 2022 Dec 12 doi: 10.1200/JCO.22.02355. PMID: 36508302
Validation of POD24 as a robust early clinical end point of poor survival in FL from 5225 patients on 13 clinical trials.
Casulo C, Dixon JG, Le-Rademacher J, Hoster E, Hochster HS, Hiddemann W, Marcus R, Kimby E, Herold M, Sebban C, Gyan E, Foon K, Nielsen T, Vitolo U, Salles GA, Shi Q, Flowers CR
Blood 2022 Mar 17;139(11):1684-1693. doi: 10.1182/blood.2020010263. PMID: 34614146Free PMC Article
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Time-Resolved scRNA-Seq Tracks the Adaptation of a Sensitive MCL Cell Line to Ibrutinib Treatment.
Fuhr V, Vafadarnejad E, Dietrich O, Arampatzi P, Riedel A, Saliba AE, Rosenwald A, Rauert-Wunderlich H
Int J Mol Sci 2021 Feb 25;22(5) doi: 10.3390/ijms22052276. PMID: 33668876Free PMC Article
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753

Recent systematic reviews

Clinical Presentation, Management, and Outcome in Neurolymphomatosis: A Systematic Review.
Kaulen LD, Hielscher T, Doubrovinskaia S, Hoffmann DC, Kessler T, Traub BL, Baehring JM, Wick W
Neurology 2024 Aug 27;103(4):e209698. Epub 2024 Aug 5 doi: 10.1212/WNL.0000000000209698. PMID: 39102613
Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Motamedi M, Xiao MZX, Deschenes J, Hardin J, Sterrett R, Street L, Taparia M, Mahe E, Ferrara G, Barrie JR, Gniadecki R
Dermatology 2024;240(3):468-473. Epub 2024 Feb 29 doi: 10.1159/000537893. PMID: 38422999
Primary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challenges.
Petrillo M, Fara AM, Fedeli MA, Fozza C, Cossu A, Gulotta A, Dessole F, Piana A, Capobianco G, Tanda F, Dessole S
Histol Histopathol 2019 Jul;34(7):723-730. Epub 2019 Jan 18 doi: 10.14670/HH-18-085. PMID: 30656635
Positron emission tomography-adapted therapy for first-line treatment in individuals with Hodgkin lymphoma.
Sickinger MT, von Tresckow B, Kobe C, Engert A, Borchmann P, Skoetz N
Cochrane Database Syst Rev 2015 Jan 9;1(1):CD010533. doi: 10.1002/14651858.CD010533.pub2. PMID: 25572491Free PMC Article
Systematic review of efficacy of dose-dense versus non-dose-dense chemotherapy in breast cancer, non-Hodgkin lymphoma, and non-small cell lung cancer.
Lyman GH, Barron RL, Natoli JL, Miller RM
Crit Rev Oncol Hematol 2012 Mar;81(3):296-308. Epub 2011 Jun 1 doi: 10.1016/j.critrevonc.2011.04.010. PMID: 21636289

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