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Intracranial arteriosclerosis

MedGen UID:
3319
Concept ID:
C0007771
Disease or Syndrome
Synonyms: Arterioscleroses, Intracranial; Arteriosclerosis, Intracranial; Intracranial Arterioscleroses; Intracranial Arteriosclerosis
 
Monarch Initiative: MONDO:0001632

Definition

Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis. [from MONDO]

Professional guidelines

PubMed

Al Kasab S, Nguyen TN, Derdeyn CP, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat OO, de Havenon A
Stroke 2024 Feb;55(2):355-365. Epub 2024 Jan 22 doi: 10.1161/STROKEAHA.123.043635. PMID: 38252763
Wabnitz AM, Turan TN
Stroke 2024 Feb;55(2):335-343. Epub 2024 Jan 22 doi: 10.1161/STROKEAHA.123.043633. PMID: 38252762
Huang J, Jiao S, Chen Y, Lu J, Song Y, Zhang J, Zhang C, Liu C, Gong T, Wang D, Zhu J, Chen M
Eur Radiol 2023 Apr;33(4):2478-2488. Epub 2022 Nov 23 doi: 10.1007/s00330-022-09218-z. PMID: 36418621

Recent clinical studies

Etiology

Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G
Neurobiol Dis 2019 Apr;124:118-132. Epub 2018 Nov 12 doi: 10.1016/j.nbd.2018.11.008. PMID: 30439443Free PMC Article
Gorelick P, Wong KS, Liu L
Front Neurol Neurosci 2016;40:34-46. Epub 2016 Dec 2 doi: 10.1159/000448272. PMID: 27960190
Uehara T, Bang OY, Kim JS, Minematsu K, Sacco R
Front Neurol Neurosci 2016;40:47-57. Epub 2016 Dec 2 doi: 10.1159/000448301. PMID: 27960158
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975

Diagnosis

Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G
Neurobiol Dis 2019 Apr;124:118-132. Epub 2018 Nov 12 doi: 10.1016/j.nbd.2018.11.008. PMID: 30439443Free PMC Article
Sharma VK, Wong KS, Alexandrov AV
Front Neurol Neurosci 2016;40:124-140. Epub 2016 Dec 2 doi: 10.1159/000448309. PMID: 27960192
Uehara T, Bang OY, Kim JS, Minematsu K, Sacco R
Front Neurol Neurosci 2016;40:47-57. Epub 2016 Dec 2 doi: 10.1159/000448301. PMID: 27960158
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975

Therapy

Ma Y, Wang T, Wang H, Amin-Hanjani S, Tong X, Wang J, Tong Z, Kuai D, Cai Y, Ren J, Wang D, Duan L, Maimaitili A, Hang C, Yu J, Bai X, Powers WJ, Derdeyn CP, Wu Y, Ling F, Gu Y, Jiao L; CMOSS Investigators
JAMA 2023 Aug 22;330(8):704-714. doi: 10.1001/jama.2023.13390. PMID: 37606672Free PMC Article
de Havenon A, Zaidat OO, Amin-Hanjani S, Nguyen TN, Bangad A, Abbasi M, Anadani M, Almallouhi E, Chatterjee R, Mazighi M, Mistry EA, Yaghi S, Derdeyn CP, Hong KS, Kvernland A, Leslie-Mazwi TM, Al Kasab S
Stroke 2023 Jun;54(6):1695-1705. Epub 2023 Mar 20 doi: 10.1161/STROKEAHA.122.040008. PMID: 36938708Free PMC Article
Gao P, Wang T, Wang D, Liebeskind DS, Shi H, Li T, Zhao Z, Cai Y, Wu W, He W, Yu J, Zheng B, Wang H, Wu Y, Dmytriw AA, Krings T, Derdeyn CP, Jiao L; CASSISS Trial Investigators
JAMA 2022 Aug 9;328(6):534-542. doi: 10.1001/jama.2022.12000. PMID: 35943472Free PMC Article
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975

Prognosis

Jia B, Zhang X, Ma N, Mo D, Gao F, Sun X, Song L, Liu L, Deng Y, Xu X, Zhang Y, Liu Z, Guan S, Zhang F, Li B, Zheng H, Liu X, Liu Y, Chen K, Shuai J, Wan J, Wang J, Shi X, Li T, Chang B, Liebeskind DS, Yu W, Miao Z; NOVA Trial Investigators
JAMA Neurol 2022 Feb 1;79(2):176-184. doi: 10.1001/jamaneurol.2021.4804. PMID: 34982098Free PMC Article
Battistella V, Elkind M
Eur J Neurol 2014 Jul;21(7):956-62. Epub 2014 Feb 24 doi: 10.1111/ene.12385. PMID: 24612339
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators
Lancet 2014 Jan 25;383(9914):333-41. Epub 2013 Oct 26 doi: 10.1016/S0140-6736(13)62038-3. PMID: 24168957Free PMC Article
Chimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, Lane BF, Janis LS, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Torbey MT, Zaidat OO, Rumboldt Z, Cloft HJ; SAMMPRIS Trial Investigators
N Engl J Med 2011 Sep 15;365(11):993-1003. Epub 2011 Sep 7 doi: 10.1056/NEJMoa1105335. PMID: 21899409Free PMC Article

Clinical prediction guides

Wang Y, Cai X, Li H, Jin A, Jiang L, Chen W, Jing J, Mei L, Li S, Meng X, Wei T, Wang Y, Pan Y, Wang Y
Eur J Neurol 2023 Sep;30(9):2700-2712. Epub 2023 Jun 23 doi: 10.1111/ene.15908. PMID: 37294661
Yin Z, Zhang Q, Zhao Y, Lu J, Ge P, Xie H, Wu D, Yu S, Kang S, Zhang Q, Zhang Y, Zhang D, Zhao J, Liu X
Stroke 2023 Jun;54(6):1484-1493. Epub 2023 May 4 doi: 10.1161/STROKEAHA.122.041553. PMID: 37139814
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Rocha EA, Topcuoglu MA, Silva GS, Singhal AB
Neurology 2019 Feb 12;92(7):e639-e647. Epub 2019 Jan 11 doi: 10.1212/WNL.0000000000006917. PMID: 30635475
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975

Recent systematic reviews

Leng X, Leung TW
Transl Stroke Res 2023 Feb;14(1):38-52. Epub 2022 Jun 8 doi: 10.1007/s12975-022-01042-3. PMID: 35672561
Kolmos M, Christoffersen L, Kruuse C
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105935. Epub 2021 Jun 18 doi: 10.1016/j.jstrokecerebrovasdis.2021.105935. PMID: 34153594
Tsang ACO, Orru E, Klostranec JM, Yang IH, Lau KK, Tsang FCP, Lui WM, Pereira VM, Krings T
Stroke 2019 Jun;50(6):1460-1466. Epub 2019 May 14 doi: 10.1161/STROKEAHA.119.024889. PMID: 31084327
Gupta A, Baradaran H, Al-Dasuqi K, Knight-Greenfield A, Giambrone AE, Delgado D, Wright D, Teng Z, Min JK, Navi BB, Iadecola C, Kamel H
J Am Heart Assoc 2016 Aug 15;5(8) doi: 10.1161/JAHA.116.003816. PMID: 27528408Free PMC Article
Zhou Y, Yang QW, Xiong HY
J Int Med Res 2012;40(1):18-27. doi: 10.1177/147323001204000103. PMID: 22429342

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