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Intracranial arteriosclerosis

MedGen UID:
3319
Concept ID:
C0007771
Disease or Syndrome
Synonyms: Arterioscleroses, Intracranial; Arteriosclerosis, Intracranial; Intracranial Arterioscleroses; Intracranial Arteriosclerosis
 
Monarch Initiative: MONDO:0001632

Definition

Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis. [from MONDO]

Professional guidelines

PubMed

Huang J, Jiao S, Chen Y, Lu J, Song Y, Zhang J, Zhang C, Liu C, Gong T, Wang D, Zhu J, Chen M
Eur Radiol 2023 Apr;33(4):2478-2488. Epub 2022 Nov 23 doi: 10.1007/s00330-022-09218-z. PMID: 36418621
Seyedsaadat SM, Yolcu YU, Neuhaus A, Rizvi A, Alzuabi M, Murad MH, Brinjikji W, Bydon M, Kallmes DF
J Neurointerv Surg 2020 Apr;12(4):380-385. Epub 2019 Nov 20 doi: 10.1136/neurintsurg-2019-015451. PMID: 31748381
Chimowitz MI
Stroke 2013 Sep;44(9):2664-9. Epub 2013 Jul 2 doi: 10.1161/STROKEAHA.113.001290. PMID: 23821232Free PMC Article

Recent clinical studies

Etiology

Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G
Neurobiol Dis 2019 Apr;124:118-132. Epub 2018 Nov 12 doi: 10.1016/j.nbd.2018.11.008. PMID: 30439443Free PMC Article
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975
Holmstedt CA, Turan TN, Chimowitz MI
Lancet Neurol 2013 Nov;12(11):1106-14. doi: 10.1016/S1474-4422(13)70195-9. PMID: 24135208Free PMC Article

Diagnosis

Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G
Neurobiol Dis 2019 Apr;124:118-132. Epub 2018 Nov 12 doi: 10.1016/j.nbd.2018.11.008. PMID: 30439443Free PMC Article
Uehara T, Bang OY, Kim JS, Minematsu K, Sacco R
Front Neurol Neurosci 2016;40:47-57. Epub 2016 Dec 2 doi: 10.1159/000448301. PMID: 27960158
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975
Holmstedt CA, Turan TN, Chimowitz MI
Lancet Neurol 2013 Nov;12(11):1106-14. doi: 10.1016/S1474-4422(13)70195-9. PMID: 24135208Free PMC Article

Therapy

Gao P, Wang T, Wang D, Liebeskind DS, Shi H, Li T, Zhao Z, Cai Y, Wu W, He W, Yu J, Zheng B, Wang H, Wu Y, Dmytriw AA, Krings T, Derdeyn CP, Jiao L; CASSISS Trial Investigators
JAMA 2022 Aug 9;328(6):534-542. doi: 10.1001/jama.2022.12000. PMID: 35943472Free PMC Article
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Uchiyama S, Toyoda K, Omae K, Saita R, Kimura K, Hoshino H, Sakai N, Okada Y, Tanaka K, Origasa H, Naritomi H, Houkin K, Yamaguchi K, Isobe M, Minematsu K, Matsumoto M, Tominaga T, Tomimoto H, Terayama Y, Yasuda S, Yamaguchi T
J Am Heart Assoc 2021 Oct 19;10(20):e022575. Epub 2021 Oct 8 doi: 10.1161/JAHA.121.022575. PMID: 34622679Free PMC Article
Qureshi AI, Caplan LR
Lancet 2014 Mar 15;383(9921):984-98. Epub 2013 Sep 2 doi: 10.1016/S0140-6736(13)61088-0. PMID: 24007975
Holmstedt CA, Turan TN, Chimowitz MI
Lancet Neurol 2013 Nov;12(11):1106-14. doi: 10.1016/S1474-4422(13)70195-9. PMID: 24135208Free PMC Article

Prognosis

Jia B, Zhang X, Ma N, Mo D, Gao F, Sun X, Song L, Liu L, Deng Y, Xu X, Zhang Y, Liu Z, Guan S, Zhang F, Li B, Zheng H, Liu X, Liu Y, Chen K, Shuai J, Wan J, Wang J, Shi X, Li T, Chang B, Liebeskind DS, Yu W, Miao Z; NOVA Trial Investigators
JAMA Neurol 2022 Feb 1;79(2):176-184. doi: 10.1001/jamaneurol.2021.4804. PMID: 34982098Free PMC Article
Amarenco P, Kim JS, Labreuche J, Charles H, Giroud M, Lavallée PC, Lee BC, Mahagne MH, Meseguer E, Nighoghossian N, Steg PG, Vicaut É, Bruckert E; Treat Stroke to Target Investigators*
Stroke 2022 Feb;53(2):457-462. Epub 2021 Dec 29 doi: 10.1161/STROKEAHA.121.035846. PMID: 34963300
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators
Lancet 2014 Jan 25;383(9914):333-41. Epub 2013 Oct 26 doi: 10.1016/S0140-6736(13)62038-3. PMID: 24168957Free PMC Article
Chimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, Lane BF, Janis LS, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Torbey MT, Zaidat OO, Rumboldt Z, Cloft HJ; SAMMPRIS Trial Investigators
N Engl J Med 2011 Sep 15;365(11):993-1003. Epub 2011 Sep 7 doi: 10.1056/NEJMoa1105335. PMID: 21899409Free PMC Article

Clinical prediction guides

Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Amarenco P, Kim JS, Labreuche J, Charles H, Giroud M, Lavallée PC, Lee BC, Mahagne MH, Meseguer E, Nighoghossian N, Steg PG, Vicaut É, Bruckert E; Treat Stroke to Target Investigators*
Stroke 2022 Feb;53(2):457-462. Epub 2021 Dec 29 doi: 10.1161/STROKEAHA.121.035846. PMID: 34963300
Chen H, Pan Y, Zong L, Jing J, Meng X, Xu Y, Yan H, Zhao X, Liu L, Li H, Johnston SC, Wang Y, Wang Y
Stroke Vasc Neurol 2020 Jun;5(2):128-137. Epub 2020 Apr 15 doi: 10.1136/svn-2019-000305. PMID: 32606085Free PMC Article
Rocha EA, Topcuoglu MA, Silva GS, Singhal AB
Neurology 2019 Feb 12;92(7):e639-e647. Epub 2019 Jan 11 doi: 10.1212/WNL.0000000000006917. PMID: 30635475
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975

Recent systematic reviews

Leng X, Leung TW
Transl Stroke Res 2023 Feb;14(1):38-52. Epub 2022 Jun 8 doi: 10.1007/s12975-022-01042-3. PMID: 35672561
Kolmos M, Christoffersen L, Kruuse C
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105935. Epub 2021 Jun 18 doi: 10.1016/j.jstrokecerebrovasdis.2021.105935. PMID: 34153594
Song JW, Pavlou A, Xiao J, Kasner SE, Fan Z, Messé SR
Stroke 2021 Jan;52(1):193-202. Epub 2020 Dec 2 doi: 10.1161/STROKEAHA.120.031480. PMID: 33370193Free PMC Article
Gupta A, Baradaran H, Al-Dasuqi K, Knight-Greenfield A, Giambrone AE, Delgado D, Wright D, Teng Z, Min JK, Navi BB, Iadecola C, Kamel H
J Am Heart Assoc 2016 Aug 15;5(8) doi: 10.1161/JAHA.116.003816. PMID: 27528408Free PMC Article
Zhou Y, Yang QW, Xiong HY
J Int Med Res 2012;40(1):18-27. doi: 10.1177/147323001204000103. PMID: 22429342

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