U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Intracranial arteriosclerosis

MedGen UID:
3319
•Concept ID:
C0007771
•
Disease or Syndrome
Synonyms: Arterioscleroses, Intracranial; Arteriosclerosis, Intracranial; Intracranial Arterioscleroses; Intracranial Arteriosclerosis
 
Monarch Initiative: MONDO:0001632

Definition

Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis. [from MONDO]

Professional guidelines

PubMed

Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions.
Al Kasab S, Nguyen TN, Derdeyn CP, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat OO, de Havenon A
Stroke 2024 Feb;55(2):355-365. Epub 2024 Jan 22 doi: 10.1161/STROKEAHA.123.043635. PMID: 38252763
Optimal Medical Management of Atherosclerotic Intracranial Stenosis.
Wabnitz AM, Turan TN
Stroke 2024 Feb;55(2):335-343. Epub 2024 Jan 22 doi: 10.1161/STROKEAHA.123.043633. PMID: 38252762
Past, Present, and Future of Intracranial Atherosclerosis Treatment.
de Havenon A, Turan TN
Stroke 2024 Feb;55(2):471-473. Epub 2023 Dec 28 doi: 10.1161/STROKEAHA.123.044270. PMID: 38152957Free PMC Article

Recent clinical studies

Etiology

Intracranial atherosclerosis update for neurointerventionalists.
Alexander MJ, Yu W
J Neurointerv Surg 2024 Apr 23;16(5):522-528. doi: 10.1136/jnis-2022-019628. PMID: 37295944
Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment.
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Intracranial atherosclerotic disease.
Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G
Neurobiol Dis 2019 Apr;124:118-132. Epub 2018 Nov 12 doi: 10.1016/j.nbd.2018.11.008. PMID: 30439443Free PMC Article
Cause and mechanisms of intracranial atherosclerosis.
Ritz K, Denswil NP, Stam OC, van Lieshout JJ, Daemen MJ
Circulation 2014 Oct 14;130(16):1407-14. doi: 10.1161/CIRCULATIONAHA.114.011147. PMID: 25311618
Endovascular advances for intracranial occlusive disease.
Binning MJ, Veznedaroglu E
Neurosurgery 2014 Feb;74 Suppl 1:S126-32. doi: 10.1227/NEU.0000000000000149. PMID: 24402481

Diagnosis

Endovascular Treatment for Acute Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Disease.
Huo X, Sun D, Chen W, Han H, Abdalkader M, Puetz V, Yi T, Wang H, Liu R, Tong X, Jia B, Ma N, Gao F, Mo D, Yan B, Mitchell PJ, Leung TW, Yavagal DR, Albers GW, Costalat V, Fiehler J, Zaidat OO, Jovin TG, Liebeskind DS, Nguyen TN, Miao Z
Semin Neurol 2023 Jun;43(3):337-344. Epub 2023 Aug 7 doi: 10.1055/s-0043-1771207. PMID: 37549690
Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment.
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Update in the treatment of intracranial atherosclerotic disease.
Barnard ZR, Alexander MJ
Stroke Vasc Neurol 2020;5(1):59-64. Epub 2019 Oct 16 doi: 10.1136/svn-2019-000279. PMID: 32411409Free PMC Article
Endovascular advances for intracranial occlusive disease.
Binning MJ, Veznedaroglu E
Neurosurgery 2014 Feb;74 Suppl 1:S126-32. doi: 10.1227/NEU.0000000000000149. PMID: 24402481
Binswanger's encephalopathy.
Lancet 1981 Apr 25;1(8226):923. PMID: 6112330

Therapy

Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment.
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Update in the treatment of intracranial atherosclerotic disease.
Barnard ZR, Alexander MJ
Stroke Vasc Neurol 2020;5(1):59-64. Epub 2019 Oct 16 doi: 10.1136/svn-2019-000279. PMID: 32411409Free PMC Article
Intracranial Atherosclerotic Disease.
Yaghi S, Prabhakaran S, Khatri P, Liebeskind DS
Stroke 2019 May;50(5):1286-1293. doi: 10.1161/STROKEAHA.118.024147. PMID: 31009344
Intracranial stenting: SAMMPRIS.
Derdeyn CP, Fiorella D, Lynn MJ, Turan TN, Lane BF, Janis LS, Chimowitz MI
Stroke 2013 Jun;44(6 Suppl 1):S41-4. doi: 10.1161/STROKEAHA.111.000370. PMID: 23709726Free PMC Article
Wherefore Wingspan?
Kallmes DF, Do HM
AJNR Am J Neuroradiol 2007 Jun-Jul;28(6):997-8. doi: 10.3174/ajnr.A0614. PMID: 17569943Free PMC Article

Prognosis

In-Stent Stenosis After Pipeline Embolization Device in Intracranial Aneurysms: Incidence, Predictors, and Clinical Outcomes.
Turhon M, Kang H, Liu J, Zhang Y, Zhang Y, Huang J, Wang K, Li M, Liu J, Zhang H, Li T, Song D, Zhao Y, Luo B, Maimaiti A, Aisha M, Wang Y, Feng W, Wang Y, Wan J, Mao G, Shi H, Yang X, Guan S
Neurosurgery 2022 Dec 1;91(6):943-951. Epub 2022 Sep 21 doi: 10.1227/neu.0000000000002142. PMID: 36129281
Bioresorbable Vascular Scaffolds in Interventional Neuroradiology.
Arat A, Daglioglu E, Akmangit I, Peker A, Arsava M, Topcuoglu MA, Belen D
Clin Neuroradiol 2018 Dec;28(4):585-592. Epub 2017 Jul 26 doi: 10.1007/s00062-017-0609-5. PMID: 28748256
Cause and mechanisms of intracranial atherosclerosis.
Ritz K, Denswil NP, Stam OC, van Lieshout JJ, Daemen MJ
Circulation 2014 Oct 14;130(16):1407-14. doi: 10.1161/CIRCULATIONAHA.114.011147. PMID: 25311618
Intracranial stenting: SAMMPRIS.
Derdeyn CP, Fiorella D, Lynn MJ, Turan TN, Lane BF, Janis LS, Chimowitz MI
Stroke 2013 Jun;44(6 Suppl 1):S41-4. doi: 10.1161/STROKEAHA.111.000370. PMID: 23709726Free PMC Article
Smoking and risk of stroke.
Hankey GJ
J Cardiovasc Risk 1999 Aug;6(4):207-11. doi: 10.1177/204748739900600403. PMID: 10501270

Clinical prediction guides

Editorial for "High-Resolution Vessel Wall MRI in Assessing Postoperative Restenosis of Intracranial Atherosclerotic Disease Before Drug-Coated Balloon Treatment: An Outcome Prediction Study".
Li J, Fan Z, Yang Q
J Magn Reson Imaging 2023 Jul;58(1):79-80. Epub 2022 Oct 28 doi: 10.1002/jmri.28502. PMID: 36305659
Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment.
Gutierrez J, Turan TN, Hoh BL, Chimowitz MI
Lancet Neurol 2022 Apr;21(4):355-368. Epub 2022 Feb 7 doi: 10.1016/S1474-4422(21)00376-8. PMID: 35143758
Pre-Admission CHADS2 and CHA2DS2-VASc Scores on Early Neurological Worsening.
Nam KW, Kim CK, Yu S, Chung JW, Bang OY, Kim GM, Jung JM, Song TJ, Kim YJ, Kim BJ, Heo SH, Park KY, Kim JM, Park JH, Choi JC, Park MS, Kim JT, Choi KH, Hwang YH, Oh K, Seo WK
Cerebrovasc Dis 2021;50(3):288-295. Epub 2021 Feb 15 doi: 10.1159/000513396. PMID: 33588410
Cryptogenic Stroke and Nonstenosing Intracranial Calcified Atherosclerosis.
Kamel H, Gialdini G, Baradaran H, Giambrone AE, Navi BB, Lerario MP, Min JK, Iadecola C, Gupta A
J Stroke Cerebrovasc Dis 2017 Apr;26(4):863-870. Epub 2016 Nov 23 doi: 10.1016/j.jstrokecerebrovasdis.2016.10.035. PMID: 27887791Free PMC Article
Arterial wall imaging.
Devuyst G, Piechowski-Józwiak BO, Bogousslavsky J
Front Neurol Neurosci 2006;21:19-26. doi: 10.1159/000092381. PMID: 17290123

Recent systematic reviews

Intracranial Atherosclerosis Disease Associated With Cognitive Impairment and Dementia: Systematic Review and Meta-Analysis.
Sabayan B, Goudarzi R, Ji Y, Borhani-Haghighi A, Olson-Bullis BA, Murray AM, Sedaghat S
J Am Heart Assoc 2023 Nov 21;12(22):e032506. Epub 2023 Nov 20 doi: 10.1161/JAHA.123.032506. PMID: 37955546Free PMC Article
Recurrent Ischemic Stroke - A Systematic Review and Meta-Analysis.
Kolmos M, Christoffersen L, Kruuse C
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105935. Epub 2021 Jun 18 doi: 10.1016/j.jstrokecerebrovasdis.2021.105935. PMID: 34153594
Revisiting the Evidence for Dipyridamole in Reducing Restenosis: A Systematic Review and Meta-analysis.
Simard T, Motazedian P, Dhaliwal S, Di Santo P, Jung RG, Ramirez FD, Labinaz A, Short S, Parlow S, Joseph J, Rasheed A, Rockley M, Marbach J, Domecq MC, Russo JJ, Chong AY, Beanlands RS, Hibbert B
J Cardiovasc Pharmacol 2021 Apr 1;77(4):450-457. doi: 10.1097/FJC.0000000000000976. PMID: 33760800
Statin Pretreatment and Microembolic Signals in Large Artery Atherosclerosis.
Safouris A, Katsanos AH, Kerasnoudis A, Krogias C, Kinsella JA, Sztajzel R, Lambadiari V, Deftereos S, Kargiotis O, Sharma VK, Demchuk AM, Saqqur M, McCabe DJH, Tsivgoulis G
Stroke 2018 Aug;49(8):1992-1995. doi: 10.1161/STROKEAHA.118.021542. PMID: 29991656
Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.
Pasterkamp G, van der Laan SW, Haitjema S, Foroughi Asl H, Siemelink MA, Bezemer T, van Setten J, Dichgans M, Malik R, Worrall BB, Schunkert H, Samani NJ, de Kleijn DP, Markus HS, Hoefer IE, Michoel T, de Jager SC, Björkegren JL, den Ruijter HM, Asselbergs FW
Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1240-6. Epub 2016 Apr 14 doi: 10.1161/ATVBAHA.115.306958. PMID: 27079880

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...