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Tropical pancreatitis

MedGen UID:
334069
•Concept ID:
C1842402
•
Disease or Syndrome
Synonym: Tropical calcific pancreatitis
SNOMED CT: Tropical calcific chronic pancreatitis (724540009)
 
Gene (location): SPINK1 (5q32)
 
Monarch Initiative: MONDO:0011986
OMIM®: 608189
Orphanet: ORPHA103918

Definition

A rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy. It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis. [from ORDO]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
•Concept ID:
C0000737
•
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
See: Feature record | Search on this feature
Neoplasm of the pancreas
MedGen UID:
18279
•Concept ID:
C0030297
•
Neoplastic Process
A tumor (abnormal growth of tissue) of the pancreas.
See: Feature record | Search on this feature
Pancreatic calcification
MedGen UID:
330843
•Concept ID:
C1842406
•
Finding
The presence of abnormal calcium deposition lesions in the pancreas.
See: Feature record | Search on this feature
Chronic pancreatitis
MedGen UID:
101753
•Concept ID:
C0149521
•
Disease or Syndrome
A chronic form of pancreatitis.
See: Feature record | Search on this feature
Insulin-dependent but ketosis-resistant diabetes
MedGen UID:
334070
•Concept ID:
C1842404
•
Finding
Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Tropical pancreatitis in Orphanet.

Professional guidelines

PubMed

Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Genotype-phenotype correlation in 9 patients with tropical pancreatitis and identified gene mutations.
Rajesh G, Elango EM, Vidya V, Balakrishnan V
Indian J Gastroenterol 2009 Mar-Apr;28(2):68-71. Epub 2009 Aug 21 doi: 10.1007/s12664-009-0022-3. PMID: 19696993
Endoscopic therapy for the treatment of pain in chronic pancreatitis: a success story in tropical pancreatitis.
Siddiqui UD, Jamidar PA
Gastrointest Endosc 2007 Jul;66(1):76-8. doi: 10.1016/j.gie.2007.05.005. PMID: 17591477

Recent clinical studies

Etiology

Diet, nutrient deficiency and chronic pancreatitis.
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum.
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Tropical pancreatitis.
Petersen JM
J Clin Gastroenterol 2002 Jul;35(1):61-6. doi: 10.1097/00004836-200207000-00013. PMID: 12080228
Chronic pancreatitis: Asia-Pacific consensus report.
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735
Observations and surgical management of tropical pancreatitis in Kerala and southern India.
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Diagnosis

Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
A clinical and radiologic review of uncommon types and causes of pancreatitis.
Shanbhogue AK, Fasih N, Surabhi VR, Doherty GP, Shanbhogue DK, Sethi SK
Radiographics 2009 Jul-Aug;29(4):1003-26. doi: 10.1148/rg.294085748. PMID: 19605653
Tropical pancreatitis.
Tandon RK
J Gastroenterol 2007 Jan;42 Suppl 17:141-7. doi: 10.1007/s00535-006-1930-y. PMID: 17238044
Tropical pancreatitis.
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Chronic pancreatitis: Asia-Pacific consensus report.
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735

Therapy

Diet, nutrient deficiency and chronic pancreatitis.
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
A fire inside: current concepts in chronic pancreatitis.
Tattersall SJ, Apte MV, Wilson JS
Intern Med J 2008 Jul;38(7):592-8. doi: 10.1111/j.1445-5994.2008.01715.x. PMID: 18715303
Disorders of the pancreas in children.
Werlin SL
Curr Opin Pediatr 1998 Oct;10(5):507-11. doi: 10.1097/00008480-199810000-00010. PMID: 9818249
Observations and surgical management of tropical pancreatitis in Kerala and southern India.
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Prognosis

Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum.
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection.
Raimondi S, Lowenfels AB, Morselli-Labate AM, Maisonneuve P, Pezzilli R
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):349-58. doi: 10.1016/j.bpg.2010.02.007. PMID: 20510834
Tropical pancreatitis.
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Chronic pancreatitis: Asia-Pacific consensus report.
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735
Tropical pancreatitis.
Ramesh H
Indian J Gastroenterol 1997 Jan;16(1):20-5. PMID: 9167376

Clinical prediction guides

Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis.
Shrikhande SV, Martignoni ME, Shrikhande M, Kappeler A, Ramesh H, Zimmermann A, Büchler MW, Friess H
Br J Surg 2003 Dec;90(12):1565-72. doi: 10.1002/bjs.4353. PMID: 14648737
Observations and surgical management of tropical pancreatitis in Kerala and southern India.
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Supplemental Content

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    • ClinVar
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      Clinical tests in GTR
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      Related records in OMIM
    • OMIM(Genes)
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