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Tropical pancreatitis

MedGen UID:
334069
Concept ID:
C1842402
Disease or Syndrome
Synonym: Tropical calcific pancreatitis
SNOMED CT: Tropical calcific chronic pancreatitis (724540009)
 
Gene (location): SPINK1 (5q32)
 
Monarch Initiative: MONDO:0011986
OMIM®: 608189
Orphanet: ORPHA103918

Definition

A rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy. It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis. [from ORDO]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Neoplasm of the pancreas
MedGen UID:
18279
Concept ID:
C0030297
Neoplastic Process
A tumor (abnormal growth of tissue) of the pancreas.
Pancreatic calcification
MedGen UID:
330843
Concept ID:
C1842406
Finding
The presence of abnormal calcium deposition lesions in the pancreas.
Chronic pancreatitis
MedGen UID:
101753
Concept ID:
C0149521
Disease or Syndrome
A chronic form of pancreatitis.
Insulin-dependent but ketosis-resistant diabetes
MedGen UID:
334070
Concept ID:
C1842404
Finding
Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Tropical pancreatitis in Orphanet.

Professional guidelines

PubMed

Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Rajesh G, Elango EM, Vidya V, Balakrishnan V
Indian J Gastroenterol 2009 Mar-Apr;28(2):68-71. Epub 2009 Aug 21 doi: 10.1007/s12664-009-0022-3. PMID: 19696993
Siddiqui UD, Jamidar PA
Gastrointest Endosc 2007 Jul;66(1):76-8. doi: 10.1016/j.gie.2007.05.005. PMID: 17591477

Recent clinical studies

Etiology

Sah DN, Bhandari RS, Singh YP, Vaidya P, Kansakar PBS, Ghimire B, Kandel B, Sah JK, Lakhey PJ
BMC Surg 2019 Sep 18;19(1):139. doi: 10.1186/s12893-019-0592-7. PMID: 31533694Free PMC Article
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Regunath H, Shivakumar BM, Kurien A, Satyamoorthy K, Pai CG
Indian J Gastroenterol 2011 Mar;30(2):78-83. Epub 2011 Apr 21 doi: 10.1007/s12664-011-0093-9. PMID: 21509539
Dhir V, Mohandas KM
Indian J Gastroenterol 1999 Jan-Mar;18(1):24-8. PMID: 10063743
Balakrishnan V, Sauniere JF, Hariharan M, Sarles H
Pancreas 1988;3(1):30-5. doi: 10.1097/00006676-198802000-00006. PMID: 3362842

Diagnosis

DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
Rerknimitr R
J Gastroenterol Hepatol 2011 Mar;26 Suppl 2:6-11. doi: 10.1111/j.1440-1746.2010.06599.x. PMID: 21323991
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Werlin SL
Curr Opin Pediatr 1998 Oct;10(5):507-11. doi: 10.1097/00008480-199810000-00010. PMID: 9818249

Therapy

Bhattacharjee PK, Mukerjee A, Adhikary C
Indian J Gastroenterol 2015 Sep;34(5):365-71. Epub 2015 Nov 16 doi: 10.1007/s12664-015-0594-z. PMID: 26573843
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Werlin SL
Curr Opin Pediatr 1998 Oct;10(5):507-11. doi: 10.1097/00008480-199810000-00010. PMID: 9818249
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Prognosis

Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Raimondi S, Lowenfels AB, Morselli-Labate AM, Maisonneuve P, Pezzilli R
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):349-58. doi: 10.1016/j.bpg.2010.02.007. PMID: 20510834
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735
Dhir V, Mohandas KM
Indian J Gastroenterol 1999 Jan-Mar;18(1):24-8. PMID: 10063743

Clinical prediction guides

Sah DN, Bhandari RS, Singh YP, Vaidya P, Kansakar PBS, Ghimire B, Kandel B, Sah JK, Lakhey PJ
BMC Surg 2019 Sep 18;19(1):139. doi: 10.1186/s12893-019-0592-7. PMID: 31533694Free PMC Article
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
Dhir V, Mohandas KM
Indian J Gastroenterol 1999 Jan-Mar;18(1):24-8. PMID: 10063743
Pitchumoni CS, Viswanathan KV, Gee Varghese PJ, Banks PA
Pancreas 1987;2(2):152-8. doi: 10.1097/00006676-198703000-00005. PMID: 3628220

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