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Short 5th finger

MedGen UID:
334269
Concept ID:
C1842878
Congenital Abnormality; Finding
Synonyms: Brachydactyly of the fifth fingers; Fifth finger brachydactyly; Fifth-finger brachydactyly; Short 5th fingers; Short fifth finger; Short fifth fingers
 
HPO: HP:0009237

Definition

Hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort 5th finger

Conditions with this feature

Professional guidelines

PubMed

Shangguan H, Wang J, Lin J, Huang X, Zeng Y, Chen R
Eur J Pediatr 2024 Mar;183(3):1403-1414. Epub 2024 Jan 3 doi: 10.1007/s00431-023-05385-3. PMID: 38170291
Urban M, Rutowski R, Urban J, Mazurek P, Kuliński S, Gosk J
Adv Clin Exp Med 2014 May-Jun;23(3):399-402. doi: 10.17219/acem/37132. PMID: 24979511

Recent clinical studies

Etiology

Olivas-Vergara O, Martínez-Estupiñán L, Romero-Bueno F, Sánchez-Pernaute O, Godo JR, Fariña-Sabaris MDC, Ruffin-Vicente B, Criado-Alcazar A, Borges PE, Recuero-Díaz S, Alvear-Torres A, Gil A, García-Fernández A, Hoyo-Fernández AE, Ortega-Trompeta MB, Sánchez-Barba-Izquierdo MI, Herrero-Beaumont G, Largo R, Naredo E
Semin Arthritis Rheum 2025 Feb;70:152612. Epub 2024 Dec 19 doi: 10.1016/j.semarthrit.2024.152612. PMID: 39729651
Zacariaz Hereter J, Rosa JE, Mollerach FB, Marin J, Ferreyra Garrott LG, Brom M, Soriano ER
Clin Rheumatol 2022 Jun;41(6):1843-1849. Epub 2022 Feb 1 doi: 10.1007/s10067-022-06079-1. PMID: 35102535
Ashkenazi S, Cohen N
Acta Psychol (Amst) 2021 Apr;215:103293. Epub 2021 Mar 18 doi: 10.1016/j.actpsy.2021.103293. PMID: 33743502
Plachy L, Dusatkova P, Maratova K, Petruzelkova L, Zemkova D, Elblova L, Kucerova P, Toni L, Kolouskova S, Snajderova M, Sumnik Z, Lebl J, Pruhova S
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgaa037. PMID: 31990356
Williams KD, Nahhas RW, Cottom CR, Lawrence S, Subedi J, Jha B, Czerwinski SA, Blangero J, Williams-Blangero S, Towne B
Am J Hum Biol 2012 Jan-Feb;24(1):68-73. Epub 2011 Dec 1 doi: 10.1002/ajhb.22205. PMID: 22131202Free PMC Article

Diagnosis

Olivas-Vergara O, Martínez-Estupiñán L, Romero-Bueno F, Sánchez-Pernaute O, Godo JR, Fariña-Sabaris MDC, Ruffin-Vicente B, Criado-Alcazar A, Borges PE, Recuero-Díaz S, Alvear-Torres A, Gil A, García-Fernández A, Hoyo-Fernández AE, Ortega-Trompeta MB, Sánchez-Barba-Izquierdo MI, Herrero-Beaumont G, Largo R, Naredo E
Semin Arthritis Rheum 2025 Feb;70:152612. Epub 2024 Dec 19 doi: 10.1016/j.semarthrit.2024.152612. PMID: 39729651
Shangguan H, Wang J, Lin J, Huang X, Zeng Y, Chen R
Eur J Pediatr 2024 Mar;183(3):1403-1414. Epub 2024 Jan 3 doi: 10.1007/s00431-023-05385-3. PMID: 38170291
Ürel-Demir G, Taşkıran EZ, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Utine GE
Eur J Med Genet 2019 Jul;62(7):103664. Epub 2019 May 5 doi: 10.1016/j.ejmg.2019.05.003. PMID: 31067494
Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
Abdelgadir D, Nowaczyk MJ, Li C
Am J Med Genet A 2013 May;161A(5):1126-31. Epub 2013 Mar 25 doi: 10.1002/ajmg.a.35812. PMID: 23529842

Therapy

Woelfle T, Pless S, Wiencierz A, Kappos L, Naegelin Y, Lorscheider J
J Med Internet Res 2021 Nov 18;23(11):e30394. doi: 10.2196/30394. PMID: 34792480Free PMC Article
Plachy L, Dusatkova P, Maratova K, Petruzelkova L, Zemkova D, Elblova L, Kucerova P, Toni L, Kolouskova S, Snajderova M, Sumnik Z, Lebl J, Pruhova S
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgaa037. PMID: 31990356
Crouter SE, de Ferranti SD, Whiteley J, Steltz SK, Osganian SK, Feldman HA, Hayman LL
PLoS One 2015;10(10):e0141584. Epub 2015 Oct 28 doi: 10.1371/journal.pone.0141584. PMID: 26510013Free PMC Article
Cannavò S, Bartolone L, Lapa D, Venturino M, Almoto B, Violi A, Trimarchi F
J Endocrinol Invest 2002 Jan;25(1):58-64. doi: 10.1007/BF03343962. PMID: 11883867
Buchner H, Kauert C, Radermacher I
Neurosci Lett 1995 Sep 22;198(1):57-9. doi: 10.1016/0304-3940(95)11950-2. PMID: 8570097

Prognosis

Olivas-Vergara O, Martínez-Estupiñán L, Romero-Bueno F, Sánchez-Pernaute O, Godo JR, Fariña-Sabaris MDC, Ruffin-Vicente B, Criado-Alcazar A, Borges PE, Recuero-Díaz S, Alvear-Torres A, Gil A, García-Fernández A, Hoyo-Fernández AE, Ortega-Trompeta MB, Sánchez-Barba-Izquierdo MI, Herrero-Beaumont G, Largo R, Naredo E
Semin Arthritis Rheum 2025 Feb;70:152612. Epub 2024 Dec 19 doi: 10.1016/j.semarthrit.2024.152612. PMID: 39729651
Saglietto A, Scarsoglio S, Canova D, De Ferrari GM, Ridolfi L, Anselmino M
Sci Rep 2023 Apr 25;13(1):6751. doi: 10.1038/s41598-023-33952-z. PMID: 37185372Free PMC Article
Zacariaz Hereter J, Rosa JE, Mollerach FB, Marin J, Ferreyra Garrott LG, Brom M, Soriano ER
Clin Rheumatol 2022 Jun;41(6):1843-1849. Epub 2022 Feb 1 doi: 10.1007/s10067-022-06079-1. PMID: 35102535
Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
Abdelgadir D, Nowaczyk MJ, Li C
Am J Med Genet A 2013 May;161A(5):1126-31. Epub 2013 Mar 25 doi: 10.1002/ajmg.a.35812. PMID: 23529842

Clinical prediction guides

Zacariaz Hereter J, Rosa JE, Mollerach FB, Marin J, Ferreyra Garrott LG, Brom M, Soriano ER
Clin Rheumatol 2022 Jun;41(6):1843-1849. Epub 2022 Feb 1 doi: 10.1007/s10067-022-06079-1. PMID: 35102535
Zahra Q, Çakmak Ç, Koprulu M, Shuaib M, Sobreira N, Kalsner L, Sobreira J, Guillen Sacoto MJ, Malik S, Tolun A
J Hum Genet 2020 Dec;65(12):1115-1123. Epub 2020 Jul 31 doi: 10.1038/s10038-020-0812-0. PMID: 32737394
Antonio DH, Magalhaes CS
Adv Rheumatol 2018 May 24;58(1):3. doi: 10.1186/s42358-018-0008-x. PMID: 30657079
Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
Rossini PM, Martino G, Narici L, Pasquarelli A, Peresson M, Pizzella V, Tecchio F, Torrioli G, Romani GL
Brain Res 1994 Apr 11;642(1-2):169-77. doi: 10.1016/0006-8993(94)90919-9. PMID: 8032877

Supplemental Content

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    Clinical resources

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