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Acute tubulointerstitial nephritis(ATIN)

MedGen UID:
334716
•Concept ID:
C1843274
•
Disease or Syndrome
Synonym: ATIN
SNOMED CT: AIN - Acute interstitial nephritis (28637003); ATIN - Acute tubulo-interstitial nephritis (28637003); Acute tubulo-interstitial nephritis (28637003); Acute tubulointerstitial nephritis (28637003); Acute interstitial nephritis (28637003); Acute tubulointerstitial disease (28637003); Acute TIN (tubulointerstitial nephritis) (28637003)
 
HPO: HP:0004729
Monarch Initiative: MONDO:0800337
OMIM®: 607665

Definition

Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute tubulointerstitial nephritis

Professional guidelines

PubMed

Immune checkpoint inhibitor-associated nephritis-treatment standard.
Barbir EB, Kitchlu A, Herrmann SM
Nephrol Dial Transplant 2024 Oct 30;39(11):1785-1798. doi: 10.1093/ndt/gfae184. PMID: 39138117
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.
Wente-Schulz S, Aksenova M, Awan A, Ambarsari CG, Becherucci F, Emma F, Fila M, Francisco T, Gokce I, Gülhan B, Hansen M, Jahnukainen T, Kallash M, Kamperis K, Mason S, Mastrangelo A, Mencarelli F, Niwinska-Faryna B, Riordan M, Rus RR, Saygili S, Serdaroglu E, Taner S, Topaloglu R, Vidal E, Woroniecki R, Yel S, Zieg J, Pape L; international TIN study group
BMJ Open 2021 May 28;11(5):e047059. doi: 10.1136/bmjopen-2020-047059. PMID: 34049919Free PMC Article
Clinical recommendations on diagnosis and treatment of immune checkpoint inhibitor-induced renal immune-related adverse events.
Zheng K, Qiu W, Wang H, Si X, Zhang X, Zhang L, Li X
Thorac Cancer 2020 Jun;11(6):1746-1751. Epub 2020 Mar 30 doi: 10.1111/1759-7714.13405. PMID: 32232975Free PMC Article

Recent clinical studies

Etiology

Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis.
Moledina DG, Obeid W, Smith RN, Rosales I, Sise ME, Moeckel G, Kashgarian M, Kuperman M, Campbell KN, Lefferts S, Meliambro K, Bitzer M, Perazella MA, Luciano RL, Pober JS, Cantley LG, Colvin RB, Wilson FP, Parikh CR
J Clin Invest 2023 Jul 3;133(13) doi: 10.1172/JCI168950. PMID: 37395276Free PMC Article
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application.
Kan WC, Chen YC, Wu VC, Shiao CC
Int J Mol Sci 2022 Feb 12;23(4) doi: 10.3390/ijms23042052. PMID: 35216167Free PMC Article
Renal Toxicity.
Abdelrahim M, Abudayyeh A
Adv Exp Med Biol 2021;1342:389-397. doi: 10.1007/978-3-030-79308-1_16. PMID: 34972976
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators
J Immunother Cancer 2021 Oct;9(10) doi: 10.1136/jitc-2021-003467. PMID: 34625513Free PMC Article

Diagnosis

Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis.
Moledina DG, Obeid W, Smith RN, Rosales I, Sise ME, Moeckel G, Kashgarian M, Kuperman M, Campbell KN, Lefferts S, Meliambro K, Bitzer M, Perazella MA, Luciano RL, Pober JS, Cantley LG, Colvin RB, Wilson FP, Parikh CR
J Clin Invest 2023 Jul 3;133(13) doi: 10.1172/JCI168950. PMID: 37395276Free PMC Article
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application.
Kan WC, Chen YC, Wu VC, Shiao CC
Int J Mol Sci 2022 Feb 12;23(4) doi: 10.3390/ijms23042052. PMID: 35216167Free PMC Article
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators
J Immunother Cancer 2021 Oct;9(10) doi: 10.1136/jitc-2021-003467. PMID: 34625513Free PMC Article
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Franzin R, Netti GS, Spadaccino F, Porta C, Gesualdo L, Stallone G, Castellano G, Ranieri E
Front Immunol 2020;11:574271. Epub 2020 Oct 8 doi: 10.3389/fimmu.2020.574271. PMID: 33162990Free PMC Article

Therapy

Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis.
Moledina DG, Obeid W, Smith RN, Rosales I, Sise ME, Moeckel G, Kashgarian M, Kuperman M, Campbell KN, Lefferts S, Meliambro K, Bitzer M, Perazella MA, Luciano RL, Pober JS, Cantley LG, Colvin RB, Wilson FP, Parikh CR
J Clin Invest 2023 Jul 3;133(13) doi: 10.1172/JCI168950. PMID: 37395276Free PMC Article
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators
J Immunother Cancer 2021 Oct;9(10) doi: 10.1136/jitc-2021-003467. PMID: 34625513Free PMC Article
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Franzin R, Netti GS, Spadaccino F, Porta C, Gesualdo L, Stallone G, Castellano G, Ranieri E
Front Immunol 2020;11:574271. Epub 2020 Oct 8 doi: 10.3389/fimmu.2020.574271. PMID: 33162990Free PMC Article
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors.
Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE
Kidney Int 2016 Sep;90(3):638-47. Epub 2016 Jun 7 doi: 10.1016/j.kint.2016.04.008. PMID: 27282937Free PMC Article

Prognosis

Facing the Challenge of Drug-Induced Acute Interstitial Nephritis.
Sanchez-Alamo B, Cases-Corona C, Fernandez-Juarez G
Nephron 2023;147(2):78-90. Epub 2022 Jul 13 doi: 10.1159/000525561. PMID: 35830831
Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application.
Kan WC, Chen YC, Wu VC, Shiao CC
Int J Mol Sci 2022 Feb 12;23(4) doi: 10.3390/ijms23042052. PMID: 35216167Free PMC Article
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators
J Immunother Cancer 2021 Oct;9(10) doi: 10.1136/jitc-2021-003467. PMID: 34625513Free PMC Article
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Franzin R, Netti GS, Spadaccino F, Porta C, Gesualdo L, Stallone G, Castellano G, Ranieri E
Front Immunol 2020;11:574271. Epub 2020 Oct 8 doi: 10.3389/fimmu.2020.574271. PMID: 33162990Free PMC Article
Acute tubulointerstitial nephritis.
Ulinski T, Sellier-Leclerc AL, Tudorache E, Bensman A, Aoun B
Pediatr Nephrol 2012 Jul;27(7):1051-7. Epub 2011 Jun 3 doi: 10.1007/s00467-011-1915-9. PMID: 21638156

Clinical prediction guides

Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis.
Moledina DG, Obeid W, Smith RN, Rosales I, Sise ME, Moeckel G, Kashgarian M, Kuperman M, Campbell KN, Lefferts S, Meliambro K, Bitzer M, Perazella MA, Luciano RL, Pober JS, Cantley LG, Colvin RB, Wilson FP, Parikh CR
J Clin Invest 2023 Jul 3;133(13) doi: 10.1172/JCI168950. PMID: 37395276Free PMC Article
Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application.
Kan WC, Chen YC, Wu VC, Shiao CC
Int J Mol Sci 2022 Feb 12;23(4) doi: 10.3390/ijms23042052. PMID: 35216167Free PMC Article
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators
J Immunother Cancer 2021 Oct;9(10) doi: 10.1136/jitc-2021-003467. PMID: 34625513Free PMC Article
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Franzin R, Netti GS, Spadaccino F, Porta C, Gesualdo L, Stallone G, Castellano G, Ranieri E
Front Immunol 2020;11:574271. Epub 2020 Oct 8 doi: 10.3389/fimmu.2020.574271. PMID: 33162990Free PMC Article
Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do?
Perazella MA, Shirali AC
Kidney Int 2020 Jan;97(1):62-74. Epub 2019 Aug 23 doi: 10.1016/j.kint.2019.07.022. PMID: 31685311

Recent systematic reviews

Clinical manifestations and outcomes in tubulointerstitial nephritis and uveitis syndrome: a case report and a systematic review in China.
Shi J, Xu S, Chen J, Wu H
Int Urol Nephrol 2024 Apr;56(4):1415-1427. Epub 2023 Sep 27 doi: 10.1007/s11255-023-03797-6. PMID: 37755610Free PMC Article
5-ASA induced interstitial nephritis in patients with inflammatory bowel disease: a systematic review.
Moss JG, Parry CM, Holt RCL, McWilliam SJ
Eur J Med Res 2022 Apr 29;27(1):61. doi: 10.1186/s40001-022-00687-y. PMID: 35488310Free PMC Article
Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review.
Martínez-Valenzuela L, Draibe J, Fulladosa X, Gomà M, Gómez F, Antón P, Cruzado JM, Torras J
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052326. PMID: 33652638Free PMC Article

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