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Duodenal ulcer due to antral G-cell hyperfunction

MedGen UID:
338843
•Concept ID:
C1852009
•
Disease or Syndrome
Synonym: Hypergastrinemic, hyperpepsinogenemic duodenal ulcer
 
Monarch Initiative: MONDO:0007474
OMIM®: 126840

Clinical features

From HPO
Duodenal ulcer
MedGen UID:
41670
•Concept ID:
C0013295
•
Disease or Syndrome
An erosion of the mucous membrane in a portion of the duodenum.
See: Feature record | Search on this feature
Hyperpepsinogenemia I
MedGen UID:
871164
•Concept ID:
C4025638
•
Disease or Syndrome
See: Feature record | Search on this feature
Hypergastrinemia
MedGen UID:
1674418
•Concept ID:
C0853890
•
Finding
An elevated amount of gastrin in the blood.
See: Feature record | Search on this feature
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Recent clinical studies

Etiology

Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study.
Sokic-Milutinovic A, Todorovic V, Milosavljevic T, Micev M, Drndarevic N, Mitrovic O
World J Gastroenterol 2005 Jul 21;11(27):4140-7. doi: 10.3748/wjg.v11.i27.4140. PMID: 16015680Free PMC Article
Relationship between fundic endocrine cells and gastric acid secretion in hypersecretory duodenal ulcer diseases.
Annibale B, Aprile MR, Ferraro G, Marignani M, Angeletti S, D'Ambra G, Caruana P, Bordi C, Delle Fave G
Aliment Pharmacol Ther 1998 Aug;12(8):779-88. doi: 10.1046/j.1365-2036.1998.00365.x. PMID: 9726392
Zollinger-Ellison syndrome and antral G-cell hyperfunction in patients with resistant duodenal ulcer disease.
Annibale B, De Magistris L, Corleto V, D'Ambra G, Marignani M, Iannoni C, Delle Fave G
Aliment Pharmacol Ther 1994 Feb;8(1):87-93. doi: 10.1111/j.1365-2036.1994.tb00164.x. PMID: 8186351
Role of serum fasting gastrin in screening for hypergastrinemic syndromes in duodenal ulcer disease.
Di Mario F, Plebani M, Gottardello L, Battaglia G, Vianello F, Farinati F, Del Favero G
Clin Biochem 1992 Apr;25(2):121-4. doi: 10.1016/0009-9120(92)80055-l. PMID: 1623579

Diagnosis

Zollinger-Ellison syndrome and antral G-cell hyperfunction in patients with resistant duodenal ulcer disease.
Annibale B, De Magistris L, Corleto V, D'Ambra G, Marignani M, Iannoni C, Delle Fave G
Aliment Pharmacol Ther 1994 Feb;8(1):87-93. doi: 10.1111/j.1365-2036.1994.tb00164.x. PMID: 8186351
Helicobacter pylori infection in children with antral gastrin cell hyperfunction.
Rindi G, Annibale B, Bonamico M, Corleto V, Delle Fave G, Solcia E
J Pediatr Gastroenterol Nutr 1994 Feb;18(2):152-8. doi: 10.1097/00005176-199402000-00006. PMID: 7912267

Therapy

Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study.
Sokic-Milutinovic A, Todorovic V, Milosavljevic T, Micev M, Drndarevic N, Mitrovic O
World J Gastroenterol 2005 Jul 21;11(27):4140-7. doi: 10.3748/wjg.v11.i27.4140. PMID: 16015680Free PMC Article
Medical treatment of antral gastrin cell hyperfunction: role of nonantisecretory therapy.
Delle Fave G, Annibale B, Puoti M, Giordano E, Corleto V, de Magistris L, Torsoli A
Digestion 1990;46(2):65-71. doi: 10.1159/000200334. PMID: 2253824
Hormonal regulation of gastric acid in peptic ulcer disease.
Lamers CB
Scand J Gastroenterol Suppl 1988;146:5-10. doi: 10.3109/00365528809099125. PMID: 2906469

Prognosis

Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study.
Sokic-Milutinovic A, Todorovic V, Milosavljevic T, Micev M, Drndarevic N, Mitrovic O
World J Gastroenterol 2005 Jul 21;11(27):4140-7. doi: 10.3748/wjg.v11.i27.4140. PMID: 16015680Free PMC Article

Clinical prediction guides

Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study.
Sokic-Milutinovic A, Todorovic V, Milosavljevic T, Micev M, Drndarevic N, Mitrovic O
World J Gastroenterol 2005 Jul 21;11(27):4140-7. doi: 10.3748/wjg.v11.i27.4140. PMID: 16015680Free PMC Article
Relationship between fundic endocrine cells and gastric acid secretion in hypersecretory duodenal ulcer diseases.
Annibale B, Aprile MR, Ferraro G, Marignani M, Angeletti S, D'Ambra G, Caruana P, Bordi C, Delle Fave G
Aliment Pharmacol Ther 1998 Aug;12(8):779-88. doi: 10.1046/j.1365-2036.1998.00365.x. PMID: 9726392
Helicobacter pylori infection in children with antral gastrin cell hyperfunction.
Rindi G, Annibale B, Bonamico M, Corleto V, Delle Fave G, Solcia E
J Pediatr Gastroenterol Nutr 1994 Feb;18(2):152-8. doi: 10.1097/00005176-199402000-00006. PMID: 7912267

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