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Hyperpepsinogenemia I

MedGen UID:
871164
•Concept ID:
C4025638
•
Disease or Syndrome
HPO: HP:0003238

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperpepsinogenemia I

Conditions with this feature

Duodenal ulcer, hyperpepsinogenemic 1
MedGen UID:
343701
•Concept ID:
C1852008
•
Disease or Syndrome
See: Condition Record
Duodenal ulcer due to antral G-cell hyperfunction
MedGen UID:
338843
•Concept ID:
C1852009
•
Disease or Syndrome
See: Condition Record
Atrial standstill 2
MedGen UID:
816731
•Concept ID:
C3810401
•
Disease or Syndrome
Atrial standstill (AS) is a rare condition characterized by the absence of electrical and mechanical activity in the atria. On surface ECG, AS is distinguished by bradycardia, junctional (usually narrow complex) escape rhythm, and absence of the P wave. Nearly 50% of patients with AS experience syncope. AS can be persistent or transient, and diffuse or partial (summary by Fazelifar et al., 2005).
See: Condition Record
Atrial standstill 2
Duodenal ulcer due to antral G-cell hyperfunction
Duodenal ulcer, hyperpepsinogenemic 1

Recent clinical studies

Etiology

Characteristics of teen-age patients with juvenile duodenal ulcer. Relation between inherited hyperpepsinogenemia I and duodenal ulcer.
Kimura M, Uemura N, Sumii K, Inbe A, Yosihara M, Haruma K, Kajiyama G
Scand J Gastroenterol 1993 Jan;28(1):25-30. doi: 10.3109/00365529309096041. PMID: 8430271
Epidemiology and genetics of peptic ulcer.
Lam SK
Gastroenterol Jpn 1993 May;28 Suppl 5:145-57. doi: 10.1007/BF02989226. PMID: 8359624
Multiplicative effect of hyperpepsinogenemia I and non-secretor status on the risk of duodenal ulcer in siblings.
Sumii K, Inbe A, Uemura N, Kimura M, Haruma K, Yoshihara M, Teshima H, Inoue K, Matsubara H, Kajiyama G
Gastroenterol Jpn 1990 Apr;25(2):157-61. doi: 10.1007/BF02776809. PMID: 2347469
Peptic ulcer: new therapies, new diseases.
Grossman MI, Kurata JH, Rotter JI, Meyer JH, Robert A, Richardson CT, Debas HT, Jensen DM
Ann Intern Med 1981 Nov;95(5):609-27. doi: 10.7326/0003-4819-95-5-609. PMID: 7027858
Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease.
Rotter JI, Petersen G, Samloff IM, McConnell RB, Ellis A, Spence MA, Rimoin DL
Ann Intern Med 1979 Sep;91(3):372-7. doi: 10.7326/0003-4819-91-3-372. PMID: 382934

Diagnosis

Helicobacter pylori clearance and serum gastrin and pepsinogen I concentrations in omeprazole treatment of duodenal ulcer patients.
Lee CT, Kuo BI, Chen CY, Chang FY, Lee SD
Eur J Clin Pharmacol 1999 Jan;54(11):817-20. doi: 10.1007/s002280050559. PMID: 10027653
Epidemiology and genetics of peptic ulcer.
Lam SK
Gastroenterol Jpn 1993 May;28 Suppl 5:145-57. doi: 10.1007/BF02989226. PMID: 8359624

Therapy

Helicobacter pylori clearance and serum gastrin and pepsinogen I concentrations in omeprazole treatment of duodenal ulcer patients.
Lee CT, Kuo BI, Chen CY, Chang FY, Lee SD
Eur J Clin Pharmacol 1999 Jan;54(11):817-20. doi: 10.1007/s002280050559. PMID: 10027653
Omeprazole treatment of severe peptic disease associated with antral G cell hyperfunction and hyperpepsinogenemia I in an infant.
De Giacomo C, Fiocca R, Villani L, Licardi G, Scotta MS, Solcia E
J Pediatr 1990 Dec;117(6):989-93. doi: 10.1016/s0022-3476(05)80152-0. PMID: 2246706

Prognosis

Helicobacter pylori clearance and serum gastrin and pepsinogen I concentrations in omeprazole treatment of duodenal ulcer patients.
Lee CT, Kuo BI, Chen CY, Chang FY, Lee SD
Eur J Clin Pharmacol 1999 Jan;54(11):817-20. doi: 10.1007/s002280050559. PMID: 10027653
Epidemiology and genetics of peptic ulcer.
Lam SK
Gastroenterol Jpn 1993 May;28 Suppl 5:145-57. doi: 10.1007/BF02989226. PMID: 8359624

Clinical prediction guides

Helicobacter pylori clearance and serum gastrin and pepsinogen I concentrations in omeprazole treatment of duodenal ulcer patients.
Lee CT, Kuo BI, Chen CY, Chang FY, Lee SD
Eur J Clin Pharmacol 1999 Jan;54(11):817-20. doi: 10.1007/s002280050559. PMID: 10027653

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