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Progressive bowing of long bones

MedGen UID:
341703
Concept ID:
C1857137
Finding
HPO: HP:0006383

Definition

Progressive bending or abnormal curvature of a long bone. [from HPO]

Conditions with this feature

Dysosteosclerosis
MedGen UID:
98150
Concept ID:
C0432262
Disease or Syndrome
A rare genetic primary bone dysplasia disease characterized by progressive osteosclerosis and platyspondyly.

Professional guidelines

PubMed

Tiegs RD
Clin Ther 1997 Nov-Dec;19(6):1309-29; discussion 1523-4. doi: 10.1016/s0149-2918(97)80007-0. PMID: 9444442
Hanscom DA, Winter RB, Lutter L, Lonstein JE, Bloom BA, Bradford DS
J Bone Joint Surg Am 1992 Apr;74(4):598-616. PMID: 1583055

Recent clinical studies

Etiology

Dhawan P, Kanojia RK, Chandra J, Kumar A, Anand R, Gupta S
J Pediatr Orthop 2020 Jul;40(6):e473-e478. doi: 10.1097/BPO.0000000000001523. PMID: 32501918
Park BK, Park KB, Kwak YH, Jin S, Kim HW, Park H
Medicine (Baltimore) 2019 Apr;98(17):e15349. doi: 10.1097/MD.0000000000015349. PMID: 31027114Free PMC Article
Florenzano P, Ferreira C, Nesterova G, Roberts MS, Tella SH, de Castro LF, Brown SM, Whitaker A, Pereira RC, Bulas D, Gafni RI, Salusky IB, Gahl WA, Collins MT
J Bone Miner Res 2018 Oct;33(10):1870-1880. Epub 2018 Jul 20 doi: 10.1002/jbmr.3522. PMID: 29905968
Stieber JR, Dormans JP
J Am Acad Orthop Surg 2005 Mar-Apr;13(2):110-20. doi: 10.5435/00124635-200503000-00004. PMID: 15850368
Tiegs RD
Clin Ther 1997 Nov-Dec;19(6):1309-29; discussion 1523-4. doi: 10.1016/s0149-2918(97)80007-0. PMID: 9444442

Diagnosis

Parameswaran AS, Singh K, Vyas V, Tada NK
J Assoc Physicians India 2023 Jan;71(1):1. PMID: 37116011
Zhytnik L, Duy BH, Eekhoff M, Wisse L, Pals G, Reimann E, Kõks S, Märtson A, Maugeri A, Maasalu K, Micha D
Genes (Basel) 2022 Feb 24;13(3) doi: 10.3390/genes13030407. PMID: 35327962Free PMC Article
Doyard M, Bacrot S, Huber C, Di Rocco M, Goldenberg A, Aglan MS, Brunelle P, Temtamy S, Michot C, Otaify GA, Haudry C, Castanet M, Leroux J, Bonnefont JP, Munnich A, Baujat G, Lapunzina P, Monnot S, Ruiz-Perez VL, Cormier-Daire V
J Med Genet 2018 Apr;55(4):278-284. Epub 2018 Jan 22 doi: 10.1136/jmedgenet-2017-104999. PMID: 29358272
Langer R, Al-Gazali L, Raupp P, Varady E
Australas Radiol 2007 Jun;51(3):203-10. doi: 10.1111/j.1440-1673.2007.01714.x. PMID: 17504309
Tiegs RD
Clin Ther 1997 Nov-Dec;19(6):1309-29; discussion 1523-4. doi: 10.1016/s0149-2918(97)80007-0. PMID: 9444442

Therapy

Prata AR, Saraiva J, Salgado M, Estanqueiro P
Joint Bone Spine 2021 Dec;88(6):105243. Epub 2021 Jun 21 doi: 10.1016/j.jbspin.2021.105243. PMID: 34166796
Dhawan P, Kanojia RK, Chandra J, Kumar A, Anand R, Gupta S
J Pediatr Orthop 2020 Jul;40(6):e473-e478. doi: 10.1097/BPO.0000000000001523. PMID: 32501918
Park BK, Park KB, Kwak YH, Jin S, Kim HW, Park H
Medicine (Baltimore) 2019 Apr;98(17):e15349. doi: 10.1097/MD.0000000000015349. PMID: 31027114Free PMC Article
Squires LA, Prangley J
Pediatr Neurol 1996 Sep;15(2):172-4. doi: 10.1016/0887-8994(96)00160-9. PMID: 8888056
Golob DS, McAlister WH, Mills BG, Fedde KN, Reinus WR, Teitelbaum SL, Beeki S, Whyte MP
J Bone Miner Res 1996 Jan;11(1):132-42. doi: 10.1002/jbmr.5650110118. PMID: 8770706

Prognosis

Parameswaran AS, Singh K, Vyas V, Tada NK
J Assoc Physicians India 2023 Jan;71(1):1. PMID: 37116011
Park BK, Park KB, Kwak YH, Jin S, Kim HW, Park H
Medicine (Baltimore) 2019 Apr;98(17):e15349. doi: 10.1097/MD.0000000000015349. PMID: 31027114Free PMC Article
Heflin JA, Ford S, Stevens P
Medicine (Baltimore) 2016 Oct;95(41):e4951. doi: 10.1097/MD.0000000000004951. PMID: 27741108Free PMC Article
Langer R, Al-Gazali L, Raupp P, Varady E
Australas Radiol 2007 Jun;51(3):203-10. doi: 10.1111/j.1440-1673.2007.01714.x. PMID: 17504309
Levine AM, Drennan JC
J Bone Joint Surg Am 1982 Oct;64(8):1158-63. PMID: 7130229

Clinical prediction guides

Ari B, Kuyubasi SN
J Pak Med Assoc 2021 May;71(5):1499-1502. doi: 10.47391/JPMA.504. PMID: 34091645
Florenzano P, Ferreira C, Nesterova G, Roberts MS, Tella SH, de Castro LF, Brown SM, Whitaker A, Pereira RC, Bulas D, Gafni RI, Salusky IB, Gahl WA, Collins MT
J Bone Miner Res 2018 Oct;33(10):1870-1880. Epub 2018 Jul 20 doi: 10.1002/jbmr.3522. PMID: 29905968
Heflin JA, Ford S, Stevens P
Medicine (Baltimore) 2016 Oct;95(41):e4951. doi: 10.1097/MD.0000000000004951. PMID: 27741108Free PMC Article
Choi IH, Kim CJ, Cho TJ, Chung CY, Song KS, Hwang JK, Sohn YJ
J Pediatr Orthop 2000 Jul-Aug;20(4):421-7. PMID: 10912595
Tiegs RD
Clin Ther 1997 Nov-Dec;19(6):1309-29; discussion 1523-4. doi: 10.1016/s0149-2918(97)80007-0. PMID: 9444442

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