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Progressive forearm bowing

MedGen UID:
463370
•Concept ID:
C3152020
•
Finding
Synonym: Progressive forearm curvature
 
HPO: HP:0005891

Definition

Progressive bending or abnormal curvature of the forearm skeleton. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive forearm bowing

Conditions with this feature

Mesomelia-synostoses syndrome
MedGen UID:
324959
•Concept ID:
C1838162
•
Disease or Syndrome
The Verloes-David-Pfeiffer mesomelia-synostoses syndrome is an autosomal dominant form of mesomelic dysplasia comprising typical acral synostoses combined with ptosis, hypertelorism, palatal abnormality, congenital heart disease, and ureteral anomalies (summary by Isidor et al., 2009). Mesomelia and synostoses are also cardinal features of the Kantaputra type of mesomelic dysplasia (156232).
See: Condition Record
Mesomelia-synostoses syndrome

Recent clinical studies

Etiology

Radiographic evaluation of ulnar deformity in patients with hereditary multiple osteochondroma and its relationship with radial head dislocation.
Massard-Combe P, Debs A, De Tienda M, Pejin Z, Gaume M, Pannier S
Orthop Traumatol Surg Res 2023 Sep;109(5):103591. Epub 2023 Mar 10 doi: 10.1016/j.otsr.2023.103591. PMID: 36905956
Wrist Joint Skeletal Changes in Children With Transfusion-dependent Thalassemia.
Dhawan P, Kanojia RK, Chandra J, Kumar A, Anand R, Gupta S
J Pediatr Orthop 2020 Jul;40(6):e473-e478. doi: 10.1097/BPO.0000000000001523. PMID: 32501918
Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors.
Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A
J Pediatr Orthop 2020 Aug;40(7):e656-e661. doi: 10.1097/BPO.0000000000001515. PMID: 31990823
Ulnar focal cortical indentation: a progressive, deforming variant of focal fibrocartilaginous dysplasia.
Goldbach AR, Zlotolow DA, Fenerty SD, Rapp J, Gershkovich G, Ali S
Pediatr Radiol 2019 Feb;49(2):187-195. Epub 2018 Nov 15 doi: 10.1007/s00247-018-4294-6. PMID: 30443667
Manifestations of hereditary multiple exostoses.
Stieber JR, Dormans JP
J Am Acad Orthop Surg 2005 Mar-Apr;13(2):110-20. doi: 10.5435/00124635-200503000-00004. PMID: 15850368

Diagnosis

Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors.
Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A
J Pediatr Orthop 2020 Aug;40(7):e656-e661. doi: 10.1097/BPO.0000000000001515. PMID: 31990823
Childhood nonunion of ulna presenting with wrist deformity in an adult: a case report.
Nithyananth M, Cherian VM, Amritanand R, Venkatesh K, Lee VN, Sundararaj GD
Arch Orthop Trauma Surg 2008 Jul;128(7):717-22. Epub 2008 Apr 30 doi: 10.1007/s00402-008-0644-4. PMID: 18509692
Hereditary multiple exostoses: from genetics to clinical syndrome and complications.
Vanhoenacker FM, Van Hul W, Wuyts W, Willems PJ, De Schepper AM
Eur J Radiol 2001 Dec;40(3):208-17. doi: 10.1016/s0720-048x(01)00401-6. PMID: 11731209

Therapy

Wrist Joint Skeletal Changes in Children With Transfusion-dependent Thalassemia.
Dhawan P, Kanojia RK, Chandra J, Kumar A, Anand R, Gupta S
J Pediatr Orthop 2020 Jul;40(6):e473-e478. doi: 10.1097/BPO.0000000000001523. PMID: 32501918
Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors.
Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A
J Pediatr Orthop 2020 Aug;40(7):e656-e661. doi: 10.1097/BPO.0000000000001515. PMID: 31990823
Childhood nonunion of ulna presenting with wrist deformity in an adult: a case report.
Nithyananth M, Cherian VM, Amritanand R, Venkatesh K, Lee VN, Sundararaj GD
Arch Orthop Trauma Surg 2008 Jul;128(7):717-22. Epub 2008 Apr 30 doi: 10.1007/s00402-008-0644-4. PMID: 18509692

Prognosis

Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors.
Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A
J Pediatr Orthop 2020 Aug;40(7):e656-e661. doi: 10.1097/BPO.0000000000001515. PMID: 31990823
Reconstruction of forearm deformity by distraction osteogenesis in children with relative shortening of the ulna due to multiple cartilaginous exostosis.
Vogt B, Tretow HL, Daniilidis K, Wacker S, Buller TC, Henrichs MP, Roedl RW, Schiedel F
J Pediatr Orthop 2011 Jun;31(4):393-401. doi: 10.1097/BPO.0b013e31821a5e27. PMID: 21572277
Tumor location affects the results of simple excision for multiple osteochondromas in the forearm.
Ishikawa J, Kato H, Fujioka F, Iwasaki N, Suenaga N, Minami A
J Bone Joint Surg Am 2007 Jun;89(6):1238-47. doi: 10.2106/JBJS.F.00298. PMID: 17545427
Ulnar focal cortical indentation: a previously unrecognised form of ulnar dysplasia.
Kazuki K, Hiroshima K, Kawahara K
J Bone Joint Surg Br 2005 Apr;87(4):540-3. doi: 10.1302/0301-620X.87B4.15141. PMID: 15795207
Management of deformities of the forearm in multiple hereditary osteochondromas.
Fogel GR, McElfresh EC, Peterson HA, Wicklund PT
J Bone Joint Surg Am 1984 Jun;66(5):670-80. PMID: 6725315

Clinical prediction guides

Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors.
Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A
J Pediatr Orthop 2020 Aug;40(7):e656-e661. doi: 10.1097/BPO.0000000000001515. PMID: 31990823
Reconstruction of forearm deformity by distraction osteogenesis in children with relative shortening of the ulna due to multiple cartilaginous exostosis.
Vogt B, Tretow HL, Daniilidis K, Wacker S, Buller TC, Henrichs MP, Roedl RW, Schiedel F
J Pediatr Orthop 2011 Jun;31(4):393-401. doi: 10.1097/BPO.0b013e31821a5e27. PMID: 21572277

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