U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subepithelial corneal opacities

MedGen UID:
341745
•Concept ID:
C1857307
•
Finding
HPO: HP:0008039

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubepithelial corneal opacities

Conditions with this feature

Francois syndrome
MedGen UID:
98151
•Concept ID:
C0432288
•
Disease or Syndrome
Dermochondrocorneal dystrophy, or Francois syndrome, is a rare disorder characterized by the development of skin nodules, acquired deformities of the extremities, and a corneal dystrophy. The corneal dystrophy is central and superficial with whitish subepithelial opacities (summary by Bierly et al., 1992).
See: Condition Record
Francois syndrome

Professional guidelines

PubMed

Genotype-Phenotype Correlation for TGFBI Corneal Dystrophies Identifies p.(G623D) as a Novel Cause of Epithelial Basement Membrane Dystrophy.
Evans CJ, Davidson AE, Carnt N, Rojas López KE, Veli N, Thaung CM, Tuft SJ, Hardcastle AJ
Invest Ophthalmol Vis Sci 2016 Oct 1;57(13):5407-5414. doi: 10.1167/iovs.16-19818. PMID: 27737463

Recent clinical studies

Etiology

Clinical Profile in Genetically Proven Blau Syndrome: A Case Series from South India.
Babu K, Rao AP
Ocul Immunol Inflamm 2021 Feb 17;29(2):250-256. Epub 2020 Apr 15 doi: 10.1080/09273948.2020.1746353. PMID: 32293936
Ocular sequelae of pneumatic drills.
Mansour AM, Uwaydat SH, Khouri AS
Eye (Lond) 2000 Feb;14 ( Pt 1):64-6. doi: 10.1038/eye.2000.14. PMID: 10755103
Recurrent subepithelial corneal opacities after excimer laser phototherapeutic keratectomy.
Starr MB
Cornea 1999 Jan;18(1):117-20. PMID: 9894948
Epidemic keratoconjunctivitis.
Murrah WF
Ann Ophthalmol 1988 Jan;20(1):36-8. PMID: 2830832

Diagnosis

Clinical Profile in Genetically Proven Blau Syndrome: A Case Series from South India.
Babu K, Rao AP
Ocul Immunol Inflamm 2021 Feb 17;29(2):250-256. Epub 2020 Apr 15 doi: 10.1080/09273948.2020.1746353. PMID: 32293936
Genotype-Phenotype Correlation for TGFBI Corneal Dystrophies Identifies p.(G623D) as a Novel Cause of Epithelial Basement Membrane Dystrophy.
Evans CJ, Davidson AE, Carnt N, Rojas López KE, Veli N, Thaung CM, Tuft SJ, Hardcastle AJ
Invest Ophthalmol Vis Sci 2016 Oct 1;57(13):5407-5414. doi: 10.1167/iovs.16-19818. PMID: 27737463
Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes.
Gore DM, Iovieno A, Connell BJ, Alexander R, Meligonis G, Dart JK
Ophthalmology 2013 May;120(5):892-8. Epub 2013 Mar 6 doi: 10.1016/j.ophtha.2012.10.037. PMID: 23474249
Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia.
Tabbara KF, Omar N, Hammouda E, Akanuma M, Ohguchi T, Ariga T, Tagawa Y, Kitaichi N, Ishida S, Aoki K, Ishiko H, Ohno S
Mol Vis 2010 Oct 24;16:2132-6. PMID: 21139691Free PMC Article
Ocular sequelae of pneumatic drills.
Mansour AM, Uwaydat SH, Khouri AS
Eye (Lond) 2000 Feb;14 ( Pt 1):64-6. doi: 10.1038/eye.2000.14. PMID: 10755103

Therapy

Corneal opacities associated with NTBC treatment.
Ahmad S, Teckman JH, Lueder GT
Am J Ophthalmol 2002 Aug;134(2):266-8. doi: 10.1016/s0002-9394(02)01532-5. PMID: 12140036
Ocular sequelae of pneumatic drills.
Mansour AM, Uwaydat SH, Khouri AS
Eye (Lond) 2000 Feb;14 ( Pt 1):64-6. doi: 10.1038/eye.2000.14. PMID: 10755103
Recurrent subepithelial corneal opacities after excimer laser phototherapeutic keratectomy.
Starr MB
Cornea 1999 Jan;18(1):117-20. PMID: 9894948
Epidemic keratoconjunctivitis.
Murrah WF
Ann Ophthalmol 1988 Jan;20(1):36-8. PMID: 2830832
Adverse ocular reactions possibly associated with isotretinoin.
Fraunfelder FT, LaBraico JM, Meyer SM
Am J Ophthalmol 1985 Oct 15;100(4):534-7. doi: 10.1016/0002-9394(85)90676-2. PMID: 2931989

Prognosis

Clinical Profile in Genetically Proven Blau Syndrome: A Case Series from South India.
Babu K, Rao AP
Ocul Immunol Inflamm 2021 Feb 17;29(2):250-256. Epub 2020 Apr 15 doi: 10.1080/09273948.2020.1746353. PMID: 32293936
Recurrent subepithelial corneal opacities after excimer laser phototherapeutic keratectomy.
Starr MB
Cornea 1999 Jan;18(1):117-20. PMID: 9894948
Epidemic keratoconjunctivitis.
Murrah WF
Ann Ophthalmol 1988 Jan;20(1):36-8. PMID: 2830832

Clinical prediction guides

Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes.
Gore DM, Iovieno A, Connell BJ, Alexander R, Meligonis G, Dart JK
Ophthalmology 2013 May;120(5):892-8. Epub 2013 Mar 6 doi: 10.1016/j.ophtha.2012.10.037. PMID: 23474249
Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia.
Tabbara KF, Omar N, Hammouda E, Akanuma M, Ohguchi T, Ariga T, Tagawa Y, Kitaichi N, Ishida S, Aoki K, Ishiko H, Ohno S
Mol Vis 2010 Oct 24;16:2132-6. PMID: 21139691Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...