U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal lacrimal duct morphology

MedGen UID:
346938
•Concept ID:
C1858567
•
Anatomical Abnormality; Finding
Synonym: Lacrimal duct abnormalities
 
HPO: HP:0011481

Definition

An abnormality of the lacrimal duct, a duct that drain tears from the conjunctiva, via the lacrimal puncta, into the lacrimal sac. [from HPO]

Professional guidelines

PubMed

Congenital nasolacrimal duct obstruction: clinical guideline.
Sasaki T, Matsumura N, Miyazaki C, Kamao T, Yokoi N, Fujimoto M, Hayami M, Iwasaki A, Mimura M, Murata A, Nakayama T, Shinomiya K, Tanaka H, Ueta Y; Congenital Nasolacrimal Duct Obstruction: Clinical Guideline Preparation Team; Committee for Congenital Nasolacrimal Duct Obstruction Clinical Guideline
Jpn J Ophthalmol 2024 Jul;68(4):367-388. Epub 2024 Aug 16 doi: 10.1007/s10384-024-01064-4. PMID: 39150609
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Treatment of Congenital Nasolacrimal Duct Obstruction.
Nelson LB
J Pediatr Ophthalmol Strabismus 2016 Sep 1;53(5):270. doi: 10.3928/01913913-20160829-01. PMID: 27637019

Recent clinical studies

Etiology

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Hereditary disorders affecting the lacrimal system.
Allen RC
Curr Opin Ophthalmol 2014 Sep;25(5):424-31. doi: 10.1097/ICU.0000000000000092. PMID: 25029093
Proboscis lateralis.
Lelli GJ Jr, Maher EA, Milite JP, Dyleski R
Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):499-501. doi: 10.1097/IOP.0b013e31818b6e57. PMID: 19033859
Midface anomalies in children.
Lowe LH, Booth TN, Joglar JM, Rollins NK
Radiographics 2000 Jul-Aug;20(4):907-22; quiz 1106-7, 1112. doi: 10.1148/radiographics.20.4.g00jl07907. PMID: 10903683

Diagnosis

Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Congenital alacrima.
Zhao Z, Allen RC
Orbit 2022 Apr;41(2):162-169. Epub 2021 Sep 5 doi: 10.1080/01676830.2021.1974057. PMID: 34486478
Congenital dacryocystocele.
Pujari A
BMJ Case Rep 2016 Dec 9;2016 doi: 10.1136/bcr-2016-218029. PMID: 27941115Free PMC Article
The lacrimal system.
Örge FH, Boente CS
Pediatr Clin North Am 2014 Jun;61(3):529-39. doi: 10.1016/j.pcl.2014.03.002. PMID: 24852150
Branchio-oto-renal syndrome.
Jalil J, Basheer F, Shafique M
J Coll Physicians Surg Pak 2014 May;24(5):367-8. PMID: 24848399

Therapy

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Intralacrimal migration of Masterka(®) stents.
Fayet B, Racy E, Katowitz WR, Katowitz JA, Ruban JM, Brémond-Gignac D
J Fr Ophtalmol 2018 Mar;41(3):206-211. Epub 2018 Mar 23 doi: 10.1016/j.jfo.2017.11.009. PMID: 29576330
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Miller MT, Ventura L, Strömland K
Birth Defects Res A Clin Mol Teratol 2009 Aug;85(8):667-76. doi: 10.1002/bdra.20609. PMID: 19639653
Congenital aberrant tearing: a re-look.
Miller MT, Strömland K, Ventura L
Trans Am Ophthalmol Soc 2008;106:100-15; discussion 115-6. PMID: 19277226Free PMC Article

Prognosis

Surgical management of congenital nasolacrimal duct obstruction; one procedure for all versus all procedures for one.
Kashkouli MB, Karimi N, Khademi B
Curr Opin Ophthalmol 2019 Sep;30(5):364-371. doi: 10.1097/ICU.0000000000000584. PMID: 31219833
Proboscis lateralis.
Lelli GJ Jr, Maher EA, Milite JP, Dyleski R
Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):499-501. doi: 10.1097/IOP.0b013e31818b6e57. PMID: 19033859
Simultaneous bilateral external dacryocystorhinostomy.
Yazici B, Akova B
Acta Ophthalmol Scand 2007 Sep;85(6):667-70. Epub 2007 Mar 15 doi: 10.1111/j.1600-0420.2007.00908.x. PMID: 17362363
Lymphoproliferative disorders of the ocular adnexa.
Cockerham GC, Jakobiec FA
Int Ophthalmol Clin 1997 Fall;37(4):39-59. doi: 10.1097/00004397-199703740-00005. PMID: 9429931
Paediatric dacryocystorhinostomy.
Hakin KN, Sullivan TJ, Sharma A, Welham RA
Aust N Z J Ophthalmol 1994 Nov;22(4):231-5. doi: 10.1111/j.1442-9071.1994.tb00789.x. PMID: 7727099

Clinical prediction guides

Lacrimo-auriculo-dento-digital syndrome with AIRE mutation: A case report.
Zhu H, Yu GY
J Stomatol Oral Maxillofac Surg 2022 Nov;123(6):e988-e990. Epub 2022 Jul 21 doi: 10.1016/j.jormas.2022.07.014. PMID: 35870793
A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human.
Schechter JE, Warren DW, Mircheff AK
Ocul Surf 2010 Jul;8(3):111-34. doi: 10.1016/s1542-0124(12)70222-7. PMID: 20712969
Congenital aberrant tearing: a re-look.
Miller MT, Strömland K, Ventura L
Trans Am Ophthalmol Soc 2008;106:100-15; discussion 115-6. PMID: 19277226Free PMC Article
Lacrimal outflow dysgenesis.
Yuen SJ, Oley C, Sullivan TJ
Ophthalmology 2004 Sep;111(9):1782-90. doi: 10.1016/j.ophtha.2004.02.011. PMID: 15350337
New autosomal dominant branchio-oculo-facial syndrome.
Fujimoto A, Lipson M, Lacro RV, Shinno NW, Boelter WD, Jones KL, Wilson MG
Am J Med Genet 1987 Aug;27(4):943-51. doi: 10.1002/ajmg.1320270422. PMID: 3321995

Recent systematic reviews

Assessing the success rate of treatment in simple and complex congenital nasolacrimal duct obstruction: a systematic review and meta-analysis.
Eshraghi B, Babaei L, Moradi M, Chaibakhsh S, Aghajani A
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):1993-2004. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06318-4. PMID: 38059998
Phenotypic spectrum of FGF10-related disorders: a systematic review.
Bzdega K, Karolak JA
PeerJ 2022;10:e14003. Epub 2022 Sep 14 doi: 10.7717/peerj.14003. PMID: 36124135Free PMC Article
Nasolacrimal Duct Probing for Young Children With Congenital Nasolacrimal Duct Obstructions in China: A 10-Year Systematic Review.
Xiang Q, Gao X, Chen X, Qi J, Fang J
J Pediatr Ophthalmol Strabismus 2019 Nov 1;56(6):365-372. doi: 10.3928/01913913-20190923-04. PMID: 31743404

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...