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Alzheimer disease without neurofibrillary tangles

MedGen UID:
346983
Concept ID:
C1858751
Disease or Syndrome
Synonyms: Alzheimer disease, type 15; Alzheimer's disease without neurofibrillary tangles
 
Monarch Initiative: MONDO:0011401
OMIM®: 604154

Professional guidelines

PubMed

Vaz M, Silvestre S
Eur J Pharmacol 2020 Nov 15;887:173554. Epub 2020 Sep 15 doi: 10.1016/j.ejphar.2020.173554. PMID: 32941929
Long JM, Holtzman DM
Cell 2019 Oct 3;179(2):312-339. Epub 2019 Sep 26 doi: 10.1016/j.cell.2019.09.001. PMID: 31564456Free PMC Article
Weller J, Budson A
F1000Res 2018;7 Epub 2018 Jul 31 doi: 10.12688/f1000research.14506.1. PMID: 30135715Free PMC Article

Recent clinical studies

Etiology

Korczyn AD, Grinberg LT
Nat Rev Neurol 2024 Apr;20(4):245-251. Epub 2024 Feb 29 doi: 10.1038/s41582-024-00940-4. PMID: 38424454
Downey J, Lam JCK, Li VOK, Gozes I
J Alzheimers Dis 2022;90(2):475-493. doi: 10.3233/JAD-220643. PMID: 36155518
Ashrafian H, Zadeh EH, Khan RH
Int J Biol Macromol 2021 Jan 15;167:382-394. Epub 2020 Dec 2 doi: 10.1016/j.ijbiomac.2020.11.192. PMID: 33278431
Flowers SA, Rebeck GW
Neurobiol Dis 2020 Mar;136:104724. Epub 2020 Jan 3 doi: 10.1016/j.nbd.2019.104724. PMID: 31911114Free PMC Article
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E
Lancet 2011 Mar 19;377(9770):1019-31. Epub 2011 Mar 1 doi: 10.1016/S0140-6736(10)61349-9. PMID: 21371747

Diagnosis

Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT
Nat Rev Dis Primers 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y. PMID: 33986301Free PMC Article
DeTure MA, Dickson DW
Mol Neurodegener 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. PMID: 31375134Free PMC Article
Bloom GS
JAMA Neurol 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. PMID: 24493463
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT
Cold Spring Harb Perspect Med 2011 Sep;1(1):a006189. doi: 10.1101/cshperspect.a006189. PMID: 22229116Free PMC Article
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E
Lancet 2011 Mar 19;377(9770):1019-31. Epub 2011 Mar 1 doi: 10.1016/S0140-6736(10)61349-9. PMID: 21371747

Therapy

Vaz M, Silvestre S
Eur J Pharmacol 2020 Nov 15;887:173554. Epub 2020 Sep 15 doi: 10.1016/j.ejphar.2020.173554. PMID: 32941929
Long JM, Holtzman DM
Cell 2019 Oct 3;179(2):312-339. Epub 2019 Sep 26 doi: 10.1016/j.cell.2019.09.001. PMID: 31564456Free PMC Article
Ozben T, Ozben S
Clin Biochem 2019 Oct;72:87-89. Epub 2019 Apr 4 doi: 10.1016/j.clinbiochem.2019.04.001. PMID: 30954437
Bloom GS
JAMA Neurol 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. PMID: 24493463
Hardy J, Selkoe DJ
Science 2002 Jul 19;297(5580):353-6. doi: 10.1126/science.1072994. PMID: 12130773

Prognosis

Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT
Nat Rev Dis Primers 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y. PMID: 33986301Free PMC Article
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG
J Biomed Sci 2019 May 9;26(1):33. doi: 10.1186/s12929-019-0524-y. PMID: 31072403Free PMC Article
Piaceri I, Nacmias B, Sorbi S
Front Biosci (Elite Ed) 2013 Jan 1;5(1):167-77. doi: 10.2741/e605. PMID: 23276979

Clinical prediction guides

Lövestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW
Nature 2024 Jan;625(7993):119-125. Epub 2023 Nov 29 doi: 10.1038/s41586-023-06788-w. PMID: 38030728Free PMC Article
Karran E, De Strooper B
Nat Rev Drug Discov 2022 Apr;21(4):306-318. Epub 2022 Feb 17 doi: 10.1038/s41573-022-00391-w. PMID: 35177833
Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Hasegawa M
Adv Exp Med Biol 2019;1184:23-34. doi: 10.1007/978-981-32-9358-8_2. PMID: 32096025
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG
J Neuropathol Exp Neurol 2012 May;71(5):362-81. doi: 10.1097/NEN.0b013e31825018f7. PMID: 22487856Free PMC Article

Recent systematic reviews

Kaul D, Ehret F, Roohani S, Jendrach M, Buthut M, Acker G, Anwar M, Zips D, Heppner F, Prüss H
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):23-41. Epub 2023 Nov 30 doi: 10.1016/j.ijrobp.2023.11.044. PMID: 38042449
Inyang D, Saumtally T, Nnadi CN, Devi S, So PW
Int J Mol Sci 2023 Jun 15;24(12) doi: 10.3390/ijms241210176. PMID: 37373321Free PMC Article
Abdulrahman H, van Dalen JW, den Brok M, Latimer CS, Larson EB, Richard E
Alzheimers Dement 2022 Nov;18(11):2308-2326. Epub 2022 Jun 27 doi: 10.1002/alz.12707. PMID: 35758526Free PMC Article
Naomi R, Embong H, Othman F, Ghazi HF, Maruthey N, Bahari H
Nutrients 2021 Dec 22;14(1) doi: 10.3390/nu14010020. PMID: 35010895Free PMC Article
Umar T, Hoda N
Curr Top Med Chem 2017;17(31):3370-3389. doi: 10.2174/1568026618666180112161024. PMID: 29332579

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