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Alzheimer disease without neurofibrillary tangles

MedGen UID:
346983
Concept ID:
C1858751
Disease or Syndrome
Synonyms: Alzheimer disease, type 15; Alzheimer's disease without neurofibrillary tangles
 
Monarch Initiative: MONDO:0011401
OMIM®: 604154

Professional guidelines

PubMed

Vaz M, Silvestre S
Eur J Pharmacol 2020 Nov 15;887:173554. Epub 2020 Sep 15 doi: 10.1016/j.ejphar.2020.173554. PMID: 32941929
Long JM, Holtzman DM
Cell 2019 Oct 3;179(2):312-339. Epub 2019 Sep 26 doi: 10.1016/j.cell.2019.09.001. PMID: 31564456Free PMC Article
Weller J, Budson A
F1000Res 2018;7 Epub 2018 Jul 31 doi: 10.12688/f1000research.14506.1. PMID: 30135715Free PMC Article

Recent clinical studies

Etiology

Korczyn AD, Grinberg LT
Nat Rev Neurol 2024 Apr;20(4):245-251. Epub 2024 Feb 29 doi: 10.1038/s41582-024-00940-4. PMID: 38424454
Downey J, Lam JCK, Li VOK, Gozes I
J Alzheimers Dis 2022;90(2):475-493. doi: 10.3233/JAD-220643. PMID: 36155518
Ashrafian H, Zadeh EH, Khan RH
Int J Biol Macromol 2021 Jan 15;167:382-394. Epub 2020 Dec 2 doi: 10.1016/j.ijbiomac.2020.11.192. PMID: 33278431
Flowers SA, Rebeck GW
Neurobiol Dis 2020 Mar;136:104724. Epub 2020 Jan 3 doi: 10.1016/j.nbd.2019.104724. PMID: 31911114Free PMC Article
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E
Lancet 2011 Mar 19;377(9770):1019-31. Epub 2011 Mar 1 doi: 10.1016/S0140-6736(10)61349-9. PMID: 21371747

Diagnosis

Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT
Nat Rev Dis Primers 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y. PMID: 33986301Free PMC Article
DeTure MA, Dickson DW
Mol Neurodegener 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. PMID: 31375134Free PMC Article
Bloom GS
JAMA Neurol 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. PMID: 24493463
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT
Cold Spring Harb Perspect Med 2011 Sep;1(1):a006189. doi: 10.1101/cshperspect.a006189. PMID: 22229116Free PMC Article
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E
Lancet 2011 Mar 19;377(9770):1019-31. Epub 2011 Mar 1 doi: 10.1016/S0140-6736(10)61349-9. PMID: 21371747

Therapy

Vaz M, Silvestre S
Eur J Pharmacol 2020 Nov 15;887:173554. Epub 2020 Sep 15 doi: 10.1016/j.ejphar.2020.173554. PMID: 32941929
Long JM, Holtzman DM
Cell 2019 Oct 3;179(2):312-339. Epub 2019 Sep 26 doi: 10.1016/j.cell.2019.09.001. PMID: 31564456Free PMC Article
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS
Brain 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777Free PMC Article
Bloom GS
JAMA Neurol 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. PMID: 24493463
Hardy J, Selkoe DJ
Science 2002 Jul 19;297(5580):353-6. doi: 10.1126/science.1072994. PMID: 12130773

Prognosis

Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT
Nat Rev Dis Primers 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y. PMID: 33986301Free PMC Article
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG
J Biomed Sci 2019 May 9;26(1):33. doi: 10.1186/s12929-019-0524-y. PMID: 31072403Free PMC Article
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Clinical prediction guides

Lövestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW
Nature 2024 Jan;625(7993):119-125. Epub 2023 Nov 29 doi: 10.1038/s41586-023-06788-w. PMID: 38030728Free PMC Article
Karran E, De Strooper B
Nat Rev Drug Discov 2022 Apr;21(4):306-318. Epub 2022 Feb 17 doi: 10.1038/s41573-022-00391-w. PMID: 35177833
Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Uddin MS, Tewari D, Mamun AA, Kabir MT, Niaz K, Wahed MII, Barreto GE, Ashraf GM
Ageing Res Rev 2020 Jul;60:101046. Epub 2020 Apr 16 doi: 10.1016/j.arr.2020.101046. PMID: 32171783
Hasegawa M
Adv Exp Med Biol 2019;1184:23-34. doi: 10.1007/978-981-32-9358-8_2. PMID: 32096025

Recent systematic reviews

Kaul D, Ehret F, Roohani S, Jendrach M, Buthut M, Acker G, Anwar M, Zips D, Heppner F, Prüss H
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):23-41. Epub 2023 Nov 30 doi: 10.1016/j.ijrobp.2023.11.044. PMID: 38042449
Inyang D, Saumtally T, Nnadi CN, Devi S, So PW
Int J Mol Sci 2023 Jun 15;24(12) doi: 10.3390/ijms241210176. PMID: 37373321Free PMC Article
Abdulrahman H, van Dalen JW, den Brok M, Latimer CS, Larson EB, Richard E
Alzheimers Dement 2022 Nov;18(11):2308-2326. Epub 2022 Jun 27 doi: 10.1002/alz.12707. PMID: 35758526Free PMC Article
Naomi R, Embong H, Othman F, Ghazi HF, Maruthey N, Bahari H
Nutrients 2021 Dec 22;14(1) doi: 10.3390/nu14010020. PMID: 35010895Free PMC Article
Bajad NG, Swetha R, Gutti G, Singh M, Kumar A, Singh SK
Future Med Chem 2021 Oct;13(19):1695-1711. Epub 2021 Sep 2 doi: 10.4155/fmc-2021-0109. PMID: 34472382

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