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Abnormal sternal ossification

MedGen UID:
348058
Concept ID:
C1860243
Finding
Synonym: Sternal ossification center abnormalities
 
HPO: HP:0011863

Definition

Any anomaly in the formation of the bony substance of the sternum. [from HPO]

Conditions with this feature

4p partial monosomy syndrome
MedGen UID:
408255
Concept ID:
C1956097
Disease or Syndrome
Wolf-Hirschhorn syndrome is a congenital malformation syndrome characterized by pre- and postnatal growth deficiency, developmental disability of variable degree, characteristic craniofacial features ('Greek warrior helmet' appearance of the nose, high forehead, prominent glabella, hypertelorism, high-arched eyebrows, protruding eyes, epicanthal folds, short philtrum, distinct mouth with downturned corners, and micrognathia), and a seizure disorder (Battaglia et al., 2008).

Professional guidelines

PubMed

Edwards DK 3rd, Berry CC, Hilton SW
Radiology 1988 May;167(2):317-8. doi: 10.1148/radiology.167.2.2965816. PMID: 2965816

Recent clinical studies

Therapy

Nagaoka LT, Jorge BC, Stein J, Manoel BM, Valente LC, de Toledo LL, de Castro TLA, Kassuya CAL, Cardoso CAL, Arena AC
Birth Defects Res 2023 Dec 1;115(20):1899-1911. Epub 2023 Oct 6 doi: 10.1002/bdr2.2257. PMID: 37800320
Park S, Kang CH, Park IK, Kim YT
J Thorac Cardiovasc Surg 2015 Mar;149(3):e53-5. Epub 2014 Nov 20 doi: 10.1016/j.jtcvs.2014.11.030. PMID: 25500290
Vegunta RK, Pacheco PE, Wallace LJ, Pearl RH
Am J Surg 2008 Mar;195(3):313-6; discussion 316-7. doi: 10.1016/j.amjsurg.2007.12.015. PMID: 18206851
Xia H, Migliazza L, Montedonico S, Rodriguez JI, Diez-Pardo JA, Tovar JA
J Pediatr Surg 1999 Sep;34(9):1385-92. doi: 10.1016/s0022-3468(99)90016-7. PMID: 10507434
Nehlig A, Debry G
Neurotoxicol Teratol 1994 Nov-Dec;16(6):531-43. doi: 10.1016/0892-0362(94)90032-9. PMID: 7862054

Prognosis

Wattamwar K, Levin TL
Pediatr Radiol 2021 Aug;51(9):1676-1681. Epub 2021 Mar 19 doi: 10.1007/s00247-021-05026-7. PMID: 33740086
Ashour M, Rafay M, Saleh W, Ahmed M, Robaidi H, Alamassi M, Al Kattan K
Asian Cardiovasc Thorac Ann 2015 Oct;23(8):961-5. Epub 2015 Jul 23 doi: 10.1177/0218492315598423. PMID: 26209602
Paraskevas G, Tzika M, Anastasopoulos N, Kitsoulis P, Sofidis G, Natsis K
Surg Radiol Anat 2015 Sep;37(7):845-51. Epub 2015 Jan 1 doi: 10.1007/s00276-014-1412-5. PMID: 25552238
LoMauro A, Pochintesta S, Romei M, D'Angelo MG, Pedotti A, Turconi AC, Aliverti A
PLoS One 2012;7(4):e35965. Epub 2012 Apr 27 doi: 10.1371/journal.pone.0035965. PMID: 22558284Free PMC Article
Jurik AG, Graudal H, de Carvalho A
Skeletal Radiol 1985;13(3):195-201. doi: 10.1007/BF00350573. PMID: 3158077

Clinical prediction guides

Nagaoka LT, Jorge BC, Stein J, Manoel BM, Valente LC, de Toledo LL, de Castro TLA, Kassuya CAL, Cardoso CAL, Arena AC
Birth Defects Res 2023 Dec 1;115(20):1899-1911. Epub 2023 Oct 6 doi: 10.1002/bdr2.2257. PMID: 37800320
Yang M, Jiang H, Yu X, Chen W, Li Q, Zhang Y, Pan B
J Comput Assist Tomogr 2017 Sep/Oct;41(5):784-791. doi: 10.1097/RCT.0000000000000590. PMID: 28296686
Gkantsinikoudis N, Chaniotakis C, Gkasdaris G, Georgiou N, Kapetanakis S
Folia Morphol (Warsz) 2017;76(3):484-490. Epub 2017 Feb 2 doi: 10.5603/FM.a2017.0006. PMID: 28150272
Paraskevas G, Tzika M, Anastasopoulos N, Kitsoulis P, Sofidis G, Natsis K
Surg Radiol Anat 2015 Sep;37(7):845-51. Epub 2015 Jan 1 doi: 10.1007/s00276-014-1412-5. PMID: 25552238
Nehlig A, Debry G
Neurotoxicol Teratol 1994 Nov-Dec;16(6):531-43. doi: 10.1016/0892-0362(94)90032-9. PMID: 7862054

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