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Tremor-nystagmus-duodenal ulcer syndrome

MedGen UID:
349908
•Concept ID:
C1860860
•
Disease or Syndrome
Synonym: Tremor, nystagmus, and duodenal ulcer
SNOMED CT: Tremor, nystagmus, duodenal ulcer syndrome (782935003); Neuhauser Daly Magnelli syndrome (782935003)
 
Monarch Initiative: MONDO:0008591
OMIM®: 190310
Orphanet: ORPHA3350

Definition

A rare hyperkinetic movement disorder with characteristics of mild to severe, progressive essential tremor, nystagmus (principally horizontal), duodenal ulceration and a narcolepsy-like sleep disturbance. Refractive errors and cerebellar signs such as gait ataxia and adiadochokinesia may be associated. There have been no further descriptions in the literature since 1976. [from SNOMEDCT_US]

Clinical features

From HPO
Duodenal ulcer
MedGen UID:
41670
•Concept ID:
C0013295
•
Disease or Syndrome
An erosion of the mucous membrane in a portion of the duodenum.
See: Feature record | Search on this feature
Tremor
MedGen UID:
21635
•Concept ID:
C0040822
•
Sign or Symptom
An unintentional, oscillating to-and-fro muscle movement about a joint axis.
See: Feature record | Search on this feature
Abnormal cerebellum morphology
MedGen UID:
400925
•Concept ID:
C1866129
•
Anatomical Abnormality
Any structural abnormality of the cerebellum.
See: Feature record | Search on this feature
Kinetic tremor
MedGen UID:
1638576
•Concept ID:
C4551521
•
Sign or Symptom
Tremor that occurs during any voluntary movement. It may include visually or non-visually guided movements. Tremor during target directed movement is called intention tremor.
See: Feature record | Search on this feature
Nystagmus
MedGen UID:
45166
•Concept ID:
C0028738
•
Disease or Syndrome
Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
Isselbacher EM, Preventza O, Hamilton Black J 3rd, Augoustides JG, Beck AW, Bolen MA, Braverman AC, Bray BE, Brown-Zimmerman MM, Chen EP, Collins TJ, DeAnda A Jr, Fanola CL, Girardi LN, Hicks CW, Hui DS, Schuyler Jones W, Kalahasti V, Kim KM, Milewicz DM, Oderich GS, Ogbechie L, Promes SB, Gyang Ross E, Schermerhorn ML, Singleton Times S, Tseng EE, Wang GJ, Woo YJ
Circulation 2022 Dec 13;146(24):e334-e482. Epub 2022 Nov 2 doi: 10.1161/CIR.0000000000001106. PMID: 36322642Free PMC Article
Acute Respiratory Distress Syndrome: Diagnosis and Management.
Saguil A, Fargo MV
Am Fam Physician 2020 Jun 15;101(12):730-738. PMID: 32538594
Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037

Recent clinical studies

Etiology

Diagnosis and Management of Acute Aortic Syndromes: Dissection, Penetrating Aortic Ulcer, and Intramural Hematoma.
Sorber R, Hicks CW
Curr Cardiol Rep 2022 Mar;24(3):209-216. Epub 2022 Jan 14 doi: 10.1007/s11886-022-01642-3. PMID: 35029783Free PMC Article
Penetrating atherosclerotic ulcer.
Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Clinical approach to cutaneous vasculitis.
Chen KR, Carlson JA
Am J Clin Dermatol 2008;9(2):71-92. doi: 10.2165/00128071-200809020-00001. PMID: 18284262
Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.
Inouye SK, Studenski S, Tinetti ME, Kuchel GA
J Am Geriatr Soc 2007 May;55(5):780-91. doi: 10.1111/j.1532-5415.2007.01156.x. PMID: 17493201Free PMC Article

Diagnosis

Diagnosis and Management of Acute Aortic Syndromes: Dissection, Penetrating Aortic Ulcer, and Intramural Hematoma.
Sorber R, Hicks CW
Curr Cardiol Rep 2022 Mar;24(3):209-216. Epub 2022 Jan 14 doi: 10.1007/s11886-022-01642-3. PMID: 35029783Free PMC Article
Acute Aortic Syndromes.
Rogers RK, Reece TB, Bonaca MP, Hess CN
Cardiol Clin 2021 Nov;39(4):495-503. doi: 10.1016/j.ccl.2021.06.002. PMID: 34686262
Solitary rectal ulcer syndrome.
Felt-Bersma RJF
Curr Opin Gastroenterol 2021 Jan;37(1):59-65. doi: 10.1097/MOG.0000000000000689. PMID: 33060396
Penetrating atherosclerotic ulcer.
Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

Therapy

Acute Aortic Syndromes.
Rogers RK, Reece TB, Bonaca MP, Hess CN
Cardiol Clin 2021 Nov;39(4):495-503. doi: 10.1016/j.ccl.2021.06.002. PMID: 34686262
Acute aortic syndromes: diagnosis and management, an update.
Bossone E, LaBounty TM, Eagle KA
Eur Heart J 2018 Mar 1;39(9):739-749d. doi: 10.1093/eurheartj/ehx319. PMID: 29106452
Review of the role of probiotics in gastrointestinal diseases in adults.
Sebastián Domingo JJ
Gastroenterol Hepatol 2017 Jun-Jul;40(6):417-429. Epub 2017 Feb 7 doi: 10.1016/j.gastrohep.2016.12.003. PMID: 28185664
Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease.
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Prognosis

Aortic Dissection and Other Acute Aortic Syndromes: Diagnostic Imaging Findings from Acute to Chronic Longitudinal Progression.
Murillo H, Molvin L, Chin AS, Fleischmann D
Radiographics 2021 Mar-Apr;41(2):425-446. doi: 10.1148/rg.2021200138. PMID: 33646901
Penetrating atherosclerotic ulcer.
Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Fu Y, Lee CH, Chi CC
JAMA Dermatol 2018 Dec 1;154(12):1417-1423. doi: 10.1001/jamadermatol.2018.3631. PMID: 30422277Free PMC Article
The role of imaging in aortic dissection and related syndromes.
Baliga RR, Nienaber CA, Bossone E, Oh JK, Isselbacher EM, Sechtem U, Fattori R, Raman SV, Eagle KA
JACC Cardiovasc Imaging 2014 Apr;7(4):406-24. doi: 10.1016/j.jcmg.2013.10.015. PMID: 24742892
Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease.
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Clinical prediction guides

Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
The 2020 update of the CEAP classification system and reporting standards.
Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Rafetto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T
J Vasc Surg Venous Lymphat Disord 2020 May;8(3):342-352. Epub 2020 Feb 27 doi: 10.1016/j.jvsv.2019.12.075. PMID: 32113854
Global vascular guidelines on the management of chronic limb-threatening ischemia.
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Gastrointestinal Behçet's disease: a review.
Skef W, Hamilton MJ, Arayssi T
World J Gastroenterol 2015 Apr 7;21(13):3801-12. doi: 10.3748/wjg.v21.i13.3801. PMID: 25852265Free PMC Article
The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum.
Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, Lohr JM, McLafferty RB, Meissner MH, Murad MH, Padberg FT, Pappas PJ, Passman MA, Raffetto JD, Vasquez MA, Wakefield TW; Society for Vascular Surgery; American Venous Forum
J Vasc Surg 2011 May;53(5 Suppl):2S-48S. doi: 10.1016/j.jvs.2011.01.079. PMID: 21536172

Recent systematic reviews

Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.
O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598
Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Global vascular guidelines on the management of chronic limb-threatening ischemia.
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Solitary rectal ulcer syndrome: A systematic review.
Forootan M, Darvishi M
Medicine (Baltimore) 2018 May;97(18):e0565. doi: 10.1097/MD.0000000000010565. PMID: 29718850Free PMC Article
Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.
Munshi L, Del Sorbo L, Adhikari NKJ, Hodgson CL, Wunsch H, Meade MO, Uleryk E, Mancebo J, Pesenti A, Ranieri VM, Fan E
Ann Am Thorac Soc 2017 Oct;14(Supplement_4):S280-S288. doi: 10.1513/AnnalsATS.201704-343OT. PMID: 29068269

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