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Tremor-nystagmus-duodenal ulcer syndrome

MedGen UID:
349908
Concept ID:
C1860860
Disease or Syndrome
Synonym: Tremor, nystagmus, and duodenal ulcer
SNOMED CT: Tremor, nystagmus, duodenal ulcer syndrome (782935003); Neuhauser Daly Magnelli syndrome (782935003)
 
Monarch Initiative: MONDO:0008591
OMIM®: 190310
Orphanet: ORPHA3350

Definition

A rare hyperkinetic movement disorder with characteristics of mild to severe, progressive essential tremor, nystagmus (principally horizontal), duodenal ulceration and a narcolepsy-like sleep disturbance. Refractive errors and cerebellar signs such as gait ataxia and adiadochokinesia may be associated. There have been no further descriptions in the literature since 1976. [from SNOMEDCT_US]

Clinical features

From HPO
Duodenal ulcer
MedGen UID:
41670
Concept ID:
C0013295
Disease or Syndrome
An erosion of the mucous membrane in a portion of the duodenum.
Tremor
MedGen UID:
21635
Concept ID:
C0040822
Sign or Symptom
An unintentional, oscillating to-and-fro muscle movement about a joint axis.
Abnormal cerebellum morphology
MedGen UID:
400925
Concept ID:
C1866129
Anatomical Abnormality
Any structural abnormality of the cerebellum.
Kinetic tremor
MedGen UID:
1638576
Concept ID:
C4551521
Sign or Symptom
Tremor that occurs during any voluntary movement. It may include visually or non-visually guided movements. Tremor during target directed movement is called intention tremor.
Nystagmus
MedGen UID:
45166
Concept ID:
C0028738
Disease or Syndrome
Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.

Professional guidelines

PubMed

Isselbacher EM, Preventza O, Hamilton Black J 3rd, Augoustides JG, Beck AW, Bolen MA, Braverman AC, Bray BE, Brown-Zimmerman MM, Chen EP, Collins TJ, DeAnda A Jr, Fanola CL, Girardi LN, Hicks CW, Hui DS, Schuyler Jones W, Kalahasti V, Kim KM, Milewicz DM, Oderich GS, Ogbechie L, Promes SB, Gyang Ross E, Schermerhorn ML, Singleton Times S, Tseng EE, Wang GJ, Woo YJ; Peer Review Committee Members
Circulation 2022 Dec 13;146(24):e334-e482. Epub 2022 Nov 2 doi: 10.1161/CIR.0000000000001106. PMID: 36322642Free PMC Article
Saguil A, Fargo MV
Am Fam Physician 2020 Jun 15;101(12):730-738. PMID: 32538594
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037

Recent clinical studies

Etiology

Sorber R, Hicks CW
Curr Cardiol Rep 2022 Mar;24(3):209-216. Epub 2022 Jan 14 doi: 10.1007/s11886-022-01642-3. PMID: 35029783Free PMC Article
Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Inouye SK, Studenski S, Tinetti ME, Kuchel GA
J Am Geriatr Soc 2007 May;55(5):780-91. doi: 10.1111/j.1532-5415.2007.01156.x. PMID: 17493201Free PMC Article
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Diagnosis

Sorber R, Hicks CW
Curr Cardiol Rep 2022 Mar;24(3):209-216. Epub 2022 Jan 14 doi: 10.1007/s11886-022-01642-3. PMID: 35029783Free PMC Article
Rogers RK, Reece TB, Bonaca MP, Hess CN
Cardiol Clin 2021 Nov;39(4):495-503. doi: 10.1016/j.ccl.2021.06.002. PMID: 34686262
Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252

Therapy

Rogers RK, Reece TB, Bonaca MP, Hess CN
Cardiol Clin 2021 Nov;39(4):495-503. doi: 10.1016/j.ccl.2021.06.002. PMID: 34686262
Rimmer LJ, Moughal S, Bashir M
Asian Cardiovasc Thorac Ann 2020 Oct;28(8):512-519. Epub 2020 Jul 16 doi: 10.1177/0218492320943350. PMID: 32674584
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Prognosis

Evangelista A, Moral S
Curr Opin Cardiol 2020 Nov;35(6):620-626. doi: 10.1097/HCO.0000000000000782. PMID: 32925190
Clough RE, Nienaber CA
Nat Rev Cardiol 2015 Feb;12(2):103-14. Epub 2014 Dec 16 doi: 10.1038/nrcardio.2014.203. PMID: 25511084
Sardana K, Goel K
Clin Dermatol 2014 Nov-Dec;32(6):817-26. Epub 2014 Oct 29 doi: 10.1016/j.clindermatol.2014.02.022. PMID: 25441476
Brown MO
Prim Care 1999 Mar;26(1):141-70. doi: 10.1016/s0095-4543(05)70106-8. PMID: 9922299
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Clinical prediction guides

Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Rafetto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T
J Vasc Surg Venous Lymphat Disord 2020 May;8(3):342-352. Epub 2020 Feb 27 doi: 10.1016/j.jvsv.2019.12.075. PMID: 32113854
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Skef W, Hamilton MJ, Arayssi T
World J Gastroenterol 2015 Apr 7;21(13):3801-12. doi: 10.3748/wjg.v21.i13.3801. PMID: 25852265Free PMC Article
Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, Lohr JM, McLafferty RB, Meissner MH, Murad MH, Padberg FT, Pappas PJ, Passman MA, Raffetto JD, Vasquez MA, Wakefield TW; Society for Vascular Surgery; American Venous Forum
J Vasc Surg 2011 May;53(5 Suppl):2S-48S. doi: 10.1016/j.jvs.2011.01.079. PMID: 21536172

Recent systematic reviews

García-Ríos P, Pecci-Lloret MP, Oñate-Sánchez RE
Int J Environ Res Public Health 2022 Sep 21;19(19) doi: 10.3390/ijerph191911910. PMID: 36231212Free PMC Article
O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Munshi L, Del Sorbo L, Adhikari NKJ, Hodgson CL, Wunsch H, Meade MO, Uleryk E, Mancebo J, Pesenti A, Ranieri VM, Fan E
Ann Am Thorac Soc 2017 Oct;14(Supplement_4):S280-S288. doi: 10.1513/AnnalsATS.201704-343OT. PMID: 29068269

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