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Prolonged miniature endplate currents

MedGen UID:
350370
Concept ID:
C1864238
Finding
Synonyms: Prolonged miniature endplate currents (MEPC); Prolonged miniature endplate potentials (MEPP)
 
HPO: HP:0003436

Definition

An abnormal prolongation of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction. [from HPO]

Conditions with this feature

Recent clinical studies

Etiology

Engel AG, Lambert EH, Mulder DM, Torres CF, Sahashi K, Bertorini TE, Whitaker JN
Ann Neurol 1982 Jun;11(6):553-69. doi: 10.1002/ana.410110603. PMID: 6287911

Diagnosis

Dissanayake KN, Margetiny F, Whitmore CL, Chou RC, Roesl C, Patel V, McArdle JJ, Webster R, Beeson D, Tattersall JEH, Wyllie DJA, Eddleston M, Ribchester RR
J Physiol 2021 Dec;599(24):5417-5449. Epub 2021 Nov 26 doi: 10.1113/JP281921. PMID: 34748643
Gomez CM, Bhattacharyya BB, Charnet P, Day JW, Labarca C, Wollmann RL, Lambert EH
Muscle Nerve 1996 Jan;19(1):79-87. doi: 10.1002/(SICI)1097-4598(199601)19:1<79::AID-MUS11>3.0.CO;2-Z. PMID: 8538674
Cull-Candy SG, Miledi R, Uchitel OD
J Physiol 1982 Dec;333:251-67. doi: 10.1113/jphysiol.1982.sp014452. PMID: 6304284Free PMC Article
Cull-Candy SG, Miledi R, Trautmann A
J Physiol 1979 Feb;287:247-65. doi: 10.1113/jphysiol.1979.sp012657. PMID: 430403Free PMC Article

Prognosis

Shen XM, Di L, Shen S, Zhao Y, Neumeyer AM, Selcen D, Sine SM, Engel AG
Exp Neurol 2020 Sep;331:113375. Epub 2020 Jun 3 doi: 10.1016/j.expneurol.2020.113375. PMID: 32504635Free PMC Article
Gomez CM, Bhattacharyya BB, Charnet P, Day JW, Labarca C, Wollmann RL, Lambert EH
Muscle Nerve 1996 Jan;19(1):79-87. doi: 10.1002/(SICI)1097-4598(199601)19:1<79::AID-MUS11>3.0.CO;2-Z. PMID: 8538674
Cull-Candy SG, Miledi R, Trautmann A
J Physiol 1979 Feb;287:247-65. doi: 10.1113/jphysiol.1979.sp012657. PMID: 430403Free PMC Article

Clinical prediction guides

Shen XM, Di L, Shen S, Zhao Y, Neumeyer AM, Selcen D, Sine SM, Engel AG
Exp Neurol 2020 Sep;331:113375. Epub 2020 Jun 3 doi: 10.1016/j.expneurol.2020.113375. PMID: 32504635Free PMC Article
Chevessier F, Peter C, Mersdorf U, Girard E, Krejci E, McArdle JJ, Witzemann V
Neurobiol Dis 2012 Mar;45(3):851-61. Epub 2011 Dec 8 doi: 10.1016/j.nbd.2011.10.024. PMID: 22178625
Gomez CM, Bhattacharyya BB, Charnet P, Day JW, Labarca C, Wollmann RL, Lambert EH
Muscle Nerve 1996 Jan;19(1):79-87. doi: 10.1002/(SICI)1097-4598(199601)19:1<79::AID-MUS11>3.0.CO;2-Z. PMID: 8538674
Hutchinson DO, Walls TJ, Nakano S, Camp S, Taylor P, Harper CM, Groover RV, Peterson HA, Jamieson DG, Engel AG
Brain 1993 Jun;116 ( Pt 3):633-53. doi: 10.1093/brain/116.3.633. PMID: 8390325

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