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Columnar Cell Change of the Breast

MedGen UID:
353552
•Concept ID:
C1707444
•
Neoplastic Process
Synonyms: Breast Columnar Cell Change; Columnar Cell Change; Columnar Cell Change of Breast

Definition

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini. The acini are lined by one or two layers of columnar epithelial cells. Apical cytoplasmic snouts may be present, but they are not prominent. Secretions may be present in the lumina of the dilated acini. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColumnar Cell Change of the Breast

Recent clinical studies

Etiology

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
The mucinous variant of columnar cell lesions.
Verschuur-Maes AH, Van Diest PJ
Histopathology 2011 May;58(6):847-53. doi: 10.1111/j.1365-2559.2011.03837.x. PMID: 21585423
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Diagnosis

Challenges and Clinical Relevance of Modern Breast Pathology Reporting: Your Questions Answered.
Deb R, Laokulrath N, Chagla L, Tan PH
Pathobiology 2024;91(4):299-312. Epub 2024 Feb 8 doi: 10.1159/000536638. PMID: 38330933
Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
The mucinous variant of columnar cell lesions.
Verschuur-Maes AH, Van Diest PJ
Histopathology 2011 May;58(6):847-53. doi: 10.1111/j.1365-2559.2011.03837.x. PMID: 21585423
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054

Prognosis

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Columnar cell lesions of the breast: mammographic and US features.
Kim MJ, Kim EK, Oh KK, Park BW, Kim H
Eur J Radiol 2006 Nov;60(2):264-9. Epub 2006 Aug 7 doi: 10.1016/j.ejrad.2006.06.013. PMID: 16891081
Molecular alterations in columnar cell lesions of the breast.
Dabbs DJ, Carter G, Fudge M, Peng Y, Swalsky P, Finkelstein S
Mod Pathol 2006 Mar;19(3):344-9. doi: 10.1038/modpathol.3800538. PMID: 16400324

Clinical prediction guides

Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast.
Gomes DS, Porto SS, Balabram D, Gobbi H
Diagn Pathol 2014 Jun 19;9:121. doi: 10.1186/1746-1596-9-121. PMID: 24948027Free PMC Article
Relationship between columnar cell changes and low-grade carcinoma in situ of the breast--a cytogenetic study.
Go EM, Tsang JY, Ni YB, Yu AM, Mendoza P, Chan SK, Lam CC, Lui PC, Tan PH, Tse GM
Hum Pathol 2012 Nov;43(11):1924-31. Epub 2012 Apr 27 doi: 10.1016/j.humpath.2012.02.001. PMID: 22542249
Proliferating activity in columnar cell lesions of the breast.
Noel JC, Fayt I, Fernandez-Aguilar S, Buxant F, Boutemy R
Virchows Arch 2006 Dec;449(6):617-21. Epub 2006 Oct 6 doi: 10.1007/s00428-006-0296-0. PMID: 17024423
Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast.
O'Malley FP, Mohsin SK, Badve S, Bose S, Collins LC, Ennis M, Kleer CG, Pinder SE, Schnitt SJ
Mod Pathol 2006 Feb;19(2):172-9. doi: 10.1038/modpathol.3800514. PMID: 16424892
Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?
Tan PH, Ho BC, Selvarajan S, Yap WM, Hanby A
J Clin Pathol 2005 Jul;58(7):705-9. doi: 10.1136/jcp.2004.025239. PMID: 15976336Free PMC Article

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