Sebaceous gland hyperplasia, familial presenile

MedGen UID:: 356529
•Concept ID:: C1866428
•: Disease or Syndrome

Synonym:	SEBACEOUS GLAND HYPERPLASIA, FAMILIAL PRESENILE

Monarch Initiative:	MONDO:0011130
OMIM®:	601700

Definition

Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently in older individuals, particularly in men past middle age (Nomland, 1930). A premature form has its appearance during puberty or just afterwards, male predominance, and excessive sebaceous secretion. Most cases are sporadic (summary by Boonchai and Leenutaphong, 1997). [from OMIM]

Clinical features

From HPO

Sebaceous hyperplasia

MedGen UID:: 98352
•Concept ID:: C0406484
•: Disease or Syndrome

A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elsewhere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola.

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Yellow papule

MedGen UID:: 1373750
•Concept ID:: C2033396
•: Finding

A papule with yellow color.

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Abnormality of the skin

MedGen UID:: 1845238
•Concept ID:: C5848159
•: Anatomical Abnormality

An abnormality of the skin.

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Abnormality of the integument

Recent clinical studies

Diagnosis

Leonine facies and neck papules.

Abdel-Halim MRE, El-Nabarawy E, El-Tawdy A, Fawzy MM, Shalaby S, Ismail S, Amer M
Int J Dermatol 2019 Jul;58(7):797-799. Epub 2019 Mar 6 doi: 10.1111/ijd.14428. PMID: 30839101

Is "premature sebaceous hyperplasia" really a sebaceous hamartoma? Report of a case with neonatal onset.

Sener S, Sasmaz S, Dogan DG, Ciralik H
Pediatr Dermatol 2011 Nov-Dec;28(6):732-733. Epub 2011 Oct 20 doi: 10.1111/j.1525-1470.2011.01484.x. PMID: 22011245

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Therapy

Leonine facies and neck papules.

Abdel-Halim MRE, El-Nabarawy E, El-Tawdy A, Fawzy MM, Shalaby S, Ismail S, Amer M
Int J Dermatol 2019 Jul;58(7):797-799. Epub 2019 Mar 6 doi: 10.1111/ijd.14428. PMID: 30839101

Presenile diffuse familial sebaceous hyperplasia successfully treated with low-dose isotretinoin: A report of two cases and review of the published work.

Liu YS, Cheng YP, Liu CI, Yang CY, Yang CY
J Dermatol 2016 Oct;43(10):1205-1208. doi: 10.1111/1346-8138.13416. PMID: 27130181

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