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Failed Back Surgery Syndrome

MedGen UID:
368458
•Concept ID:
C1963763
•
Disease or Syndrome

Definition

A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFailed Back Surgery Syndrome

Professional guidelines

PubMed

Pathogenesis, etiology and treatment of failed back surgery syndrome.
Alizadeh R, Sharifzadeh SR
Neurochirurgie 2022 Jul;68(4):426-431. Epub 2021 Sep 17 doi: 10.1016/j.neuchi.2021.09.005. PMID: 34543614
Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application.
Sun L, Peng C, Joosten E, Cheung CW, Tan F, Jiang W, Shen X
Neural Plast 2021;2021:5607898. Epub 2021 Oct 21 doi: 10.1155/2021/5607898. PMID: 34721569Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Recent clinical studies

Etiology

Teleexercise for geriatric patients with failed back surgery syndrome.
Alizadeh R, Anastasio AT, Shariat A, Bethell M, Hassanzadeh G
Front Public Health 2023;11:1140506. Epub 2023 Mar 23 doi: 10.3389/fpubh.2023.1140506. PMID: 37081949Free PMC Article
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Diagnosis

Failed Back Surgery Syndrome: No Longer a Surgeon's Defeat-A Narrative Review.
Miękisiak G
Medicina (Kaunas) 2023 Jul 6;59(7) doi: 10.3390/medicina59071255. PMID: 37512066Free PMC Article
Teleexercise for geriatric patients with failed back surgery syndrome.
Alizadeh R, Anastasio AT, Shariat A, Bethell M, Hassanzadeh G
Front Public Health 2023;11:1140506. Epub 2023 Mar 23 doi: 10.3389/fpubh.2023.1140506. PMID: 37081949Free PMC Article
The aetiologies of Failed Back Surgery Syndrome: A systematic review.
Clancy C, Quinn A, Wilson F
J Back Musculoskelet Rehabil 2017;30(3):395-402. doi: 10.3233/BMR-150318. PMID: 27689601
Acute and chronic pain: where we are and where we have to go.
Allegri M, Clark MR, De Andrés J, Jensen TS
Minerva Anestesiol 2012 Feb;78(2):222-35. Epub 2011 Nov 18 PMID: 22095106
Failed back surgery syndrome.
Chan CW, Peng P
Pain Med 2011 Apr;12(4):577-606. Epub 2011 Apr 4 doi: 10.1111/j.1526-4637.2011.01089.x. PMID: 21463472

Therapy

Neuromodulation for chronic pain.
Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA
Lancet 2021 May 29;397(10289):2111-2124. doi: 10.1016/S0140-6736(21)00794-7. PMID: 34062145
Spinal Cord Stimulation.
Rock AK, Truong H, Park YL, Pilitsis JG
Neurosurg Clin N Am 2019 Apr;30(2):169-194. Epub 2019 Feb 18 doi: 10.1016/j.nec.2018.12.003. PMID: 30898269
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms.
Sdrulla AD, Guan Y, Raja SN
Pain Pract 2018 Nov;18(8):1048-1067. Epub 2018 Apr 23 doi: 10.1111/papr.12692. PMID: 29526043Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Prognosis

Spinal cord stimulation and return to work of patients with failed back surgery syndrome.
Dauriac-Le Masson V, Gatt MT, Chekroun C, Turak B, Djian MC
Pain Pract 2023 Jun;23(5):493-500. Epub 2023 Jan 27 doi: 10.1111/papr.13205. PMID: 36680372
Application of the novel Nalu™ Neurostimulation System for peripheral nerve stimulation.
Kalia H, Pritzlaff S, Li AH, Ottestad E, Gulati A, Makous J, Chakravarthy K
Pain Manag 2022 Oct;12(7):795-804. Epub 2022 Aug 10 doi: 10.2217/pmt-2021-0050. PMID: 35946308
The incidence of failed back surgery syndrome varies between clinical setting and procedure type.
Stanton EW, Chang KE, Formanek B, Buser Z, Wang J
J Clin Neurosci 2022 Sep;103:56-61. Epub 2022 Jul 8 doi: 10.1016/j.jocn.2022.06.027. PMID: 35810607
Dextrose injections for failed back surgery syndrome: a consecutive case series.
Solmaz İ, Akpancar S, Örsçelik A, Yener-Karasimav Ö, Gül D
Eur Spine J 2019 Jul;28(7):1610-1617. Epub 2019 May 21 doi: 10.1007/s00586-019-06011-3. PMID: 31115685
The failed back surgery syndrome: pitfalls surrounding evaluation and treatment.
Shapiro CM
Phys Med Rehabil Clin N Am 2014 May;25(2):319-40. doi: 10.1016/j.pmr.2014.01.014. PMID: 24787336

Clinical prediction guides

Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Spinal cord stimulation: beyond pain management.
Tapias Pérez JH
Neurologia (Engl Ed) 2022 Sep;37(7):586-595. Epub 2021 May 25 doi: 10.1016/j.nrleng.2019.05.007. PMID: 36064287
Spinal cord stimulation: Beyond pain management.
Tapia Pérez JH
Neurologia (Engl Ed) 2022 Sep;37(7):586-595. Epub 2019 Jul 21 doi: 10.1016/j.nrl.2019.05.009. PMID: 31337556
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Failed back surgery syndrome: foreword.
Carney AL
Neurochirurgie 2015 Mar;61 Suppl 1:S1-4. Epub 2015 Feb 9 doi: 10.1016/j.neuchi.2013.11.009. PMID: 25676908

Recent systematic reviews

Effectiveness of Epiduroscopy for Patients with Failed Back Surgery Syndrome: A Systematic Review and Meta-analysis.
Geudeke MW, Krediet AC, Bilecen S, Huygen FJPM, Rijsdijk M
Pain Pract 2021 Apr;21(4):468-481. Epub 2020 Dec 26 doi: 10.1111/papr.12974. PMID: 33274591Free PMC Article
Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
Treatment Outcomes for Patients with Failed Back Surgery.
Cho JH, Lee JH, Song KS, Hong JY, Joo YS, Lee DH, Hwang CJ, Lee CS
Pain Physician 2017 Jan-Feb;20(1):E29-E43. PMID: 28072795
The aetiologies of Failed Back Surgery Syndrome: A systematic review.
Clancy C, Quinn A, Wilson F
J Back Musculoskelet Rehabil 2017;30(3):395-402. doi: 10.3233/BMR-150318. PMID: 27689601
A Systematic Evaluation of Burst Spinal Cord Stimulation for Chronic Back and Limb Pain.
Hou S, Kemp K, Grabois M
Neuromodulation 2016 Jun;19(4):398-405. Epub 2016 May 3 doi: 10.1111/ner.12440. PMID: 27139915

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