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Failed Back Surgery Syndrome

MedGen UID:
368458
•Concept ID:
C1963763
•
Disease or Syndrome

Definition

A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFailed Back Surgery Syndrome

Professional guidelines

PubMed

Pathogenesis, etiology and treatment of failed back surgery syndrome.
Alizadeh R, Sharifzadeh SR
Neurochirurgie 2022 Jul;68(4):426-431. Epub 2021 Sep 17 doi: 10.1016/j.neuchi.2021.09.005. PMID: 34543614
Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application.
Sun L, Peng C, Joosten E, Cheung CW, Tan F, Jiang W, Shen X
Neural Plast 2021;2021:5607898. Epub 2021 Oct 21 doi: 10.1155/2021/5607898. PMID: 34721569Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Recent clinical studies

Etiology

Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Spinal cord stimulation for neuropathic pain.
Fontaine D
Rev Neurol (Paris) 2021 Sep;177(7):838-842. Epub 2021 Aug 9 doi: 10.1016/j.neurol.2021.07.014. PMID: 34384626
Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Diagnosis

Failed Back Surgery Syndrome: No Longer a Surgeon's Defeat-A Narrative Review.
Miękisiak G
Medicina (Kaunas) 2023 Jul 6;59(7) doi: 10.3390/medicina59071255. PMID: 37512066Free PMC Article
Effectiveness of Spinal Cord Stimulation in Chronic Spinal Pain: A Systematic Review.
Grider JS, Manchikanti L, Carayannopoulos A, Sharma ML, Balog CC, Harned ME, Grami V, Justiz R, Nouri KH, Hayek SM, Vallejo R, Christo PJ
Pain Physician 2016 Jan;19(1):E33-54. PMID: 26752493
Acute and chronic pain: where we are and where we have to go.
Allegri M, Clark MR, De Andrés J, Jensen TS
Minerva Anestesiol 2012 Feb;78(2):222-35. Epub 2011 Nov 18 PMID: 22095106
Failed back surgery syndrome.
Chan CW, Peng P
Pain Med 2011 Apr;12(4):577-606. Epub 2011 Apr 4 doi: 10.1111/j.1526-4637.2011.01089.x. PMID: 21463472
Failed back surgery syndrome.
Long DM
Neurosurg Clin N Am 1991 Oct;2(4):899-919. PMID: 1840393

Therapy

Neuromodulation for chronic pain.
Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA
Lancet 2021 May 29;397(10289):2111-2124. doi: 10.1016/S0140-6736(21)00794-7. PMID: 34062145
Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
Spinal Cord Stimulation.
Rock AK, Truong H, Park YL, Pilitsis JG
Neurosurg Clin N Am 2019 Apr;30(2):169-194. Epub 2019 Feb 18 doi: 10.1016/j.nec.2018.12.003. PMID: 30898269
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms.
Sdrulla AD, Guan Y, Raja SN
Pain Pract 2018 Nov;18(8):1048-1067. Epub 2018 Apr 23 doi: 10.1111/papr.12692. PMID: 29526043Free PMC Article

Prognosis

The incidence of failed back surgery syndrome varies between clinical setting and procedure type.
Stanton EW, Chang KE, Formanek B, Buser Z, Wang J
J Clin Neurosci 2022 Sep;103:56-61. Epub 2022 Jul 8 doi: 10.1016/j.jocn.2022.06.027. PMID: 35810607
Dextrose injections for failed back surgery syndrome: a consecutive case series.
Solmaz İ, Akpancar S, Örsçelik A, Yener-Karasimav Ö, Gül D
Eur Spine J 2019 Jul;28(7):1610-1617. Epub 2019 May 21 doi: 10.1007/s00586-019-06011-3. PMID: 31115685
Temperament and Character Profile in Failed Back Surgery Syndrome: A Cross-Sectional Clinical Study.
Yalbuzdag SA, Erol AM, Sengul I, Celik C, Solum S, Adilay HU, Gungor B
Turk Neurosurg 2016;26(6):912-917. doi: 10.5137/1019-5149.JTN.13679-14.0. PMID: 27476913
The failed back surgery syndrome: pitfalls surrounding evaluation and treatment.
Shapiro CM
Phys Med Rehabil Clin N Am 2014 May;25(2):319-40. doi: 10.1016/j.pmr.2014.01.014. PMID: 24787336
Management of back pain in patients with previous back surgery.
Ragab A, Deshazo RD
Am J Med 2008 Apr;121(4):272-8. doi: 10.1016/j.amjmed.2008.01.004. PMID: 18374682

Clinical prediction guides

Lumbar interbody fusion using oblique (OLIF) and lateral (LLIF) approaches for degenerative spine disorders: a meta-analysis of the comparative studies.
Ricciardi L, Piazza A, Capobianco M, Della Pepa GM, Miscusi M, Raco A, Scerrati A, Somma T, Lofrese G, Sturiale CL
Eur J Orthop Surg Traumatol 2023 Jan;33(1):1-7. Epub 2021 Nov 26 doi: 10.1007/s00590-021-03172-0. PMID: 34825987
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Spinal cord stimulation: beyond pain management.
Tapias Pérez JH
Neurologia (Engl Ed) 2022 Sep;37(7):586-595. Epub 2021 May 25 doi: 10.1016/j.nrleng.2019.05.007. PMID: 36064287
Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial.
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J
JAMA Neurol 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492. PMID: 29710099Free PMC Article
Failed back surgery syndrome: foreword.
Carney AL
Neurochirurgie 2015 Mar;61 Suppl 1:S1-4. Epub 2015 Feb 9 doi: 10.1016/j.neuchi.2013.11.009. PMID: 25676908

Recent systematic reviews

Lumbar interbody fusion using oblique (OLIF) and lateral (LLIF) approaches for degenerative spine disorders: a meta-analysis of the comparative studies.
Ricciardi L, Piazza A, Capobianco M, Della Pepa GM, Miscusi M, Raco A, Scerrati A, Somma T, Lofrese G, Sturiale CL
Eur J Orthop Surg Traumatol 2023 Jan;33(1):1-7. Epub 2021 Nov 26 doi: 10.1007/s00590-021-03172-0. PMID: 34825987
Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
The aetiologies of Failed Back Surgery Syndrome: A systematic review.
Clancy C, Quinn A, Wilson F
J Back Musculoskelet Rehabil 2017;30(3):395-402. doi: 10.3233/BMR-150318. PMID: 27689601
Effectiveness of Spinal Cord Stimulation in Chronic Spinal Pain: A Systematic Review.
Grider JS, Manchikanti L, Carayannopoulos A, Sharma ML, Balog CC, Harned ME, Grami V, Justiz R, Nouri KH, Hayek SM, Vallejo R, Christo PJ
Pain Physician 2016 Jan;19(1):E33-54. PMID: 26752493
Does mindfulness improve outcomes in patients with chronic pain? Systematic review and meta-analysis.
Bawa FL, Mercer SW, Atherton RJ, Clague F, Keen A, Scott NW, Bond CM
Br J Gen Pract 2015 Jun;65(635):e387-400. doi: 10.3399/bjgp15X685297. PMID: 26009534Free PMC Article

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