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Cervical Glandular Intraepithelial Neoplasia

MedGen UID:
384477
•Concept ID:
C2044987
•
Neoplastic Process

Definition

A neoplastic process that affects the glandular epithelial cells of the cervix. There is no evidence of invasion. It is classified as low or high grade. [from NCI]

Professional guidelines

PubMed

Improved national Croatian diagnostic and therapeutic guidelines for premalignant lesions of the uterine cervix with some cost-benefit aspects.
Ljubojević N, Babić S, Audy-Jurković S, Ovanin-Rakić A, Jukić S, Babić D, Grubisić G, Radaković B, Ljubojević-Grgec D
Coll Antropol 2001 Dec;25(2):467-74. PMID: 11811276

Recent clinical studies

Etiology

Cervical glandular neoplasia referrals and the diagnosis of adenocarcinoma in situ: Correlating cytology, colposcopy findings, and clinical outcomes.
Nikolopoulos M, Athanasias P, Godfrey MAL, Nikolopoulos K, Maheshwari MK
Cytopathology 2021 Nov;32(6):751-757. Epub 2021 Jul 20 doi: 10.1111/cyt.13027. PMID: 34181788
Study of clinical diagnosis of cervical glandular intraepithelial neoplasia.
Yang S, Duan W, Kong W, Zhu L, Wu Y
Eur J Gynaecol Oncol 2016 Aug;37(4):539-542. PMID: 29894080
Factors influencing decisions about surgical treatment of cervical precancerous lesions.
Sehnal B, Cibula D, Slama J
Expert Rev Anticancer Ther 2014 Apr;14(4):441-51. Epub 2014 Feb 24 doi: 10.1586/14737140.2014.867810. PMID: 24559302
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Aetiology, pathogenesis, and pathology of cervical neoplasia.
Arends MJ, Buckley CH, Wells M
J Clin Pathol 1998 Feb;51(2):96-103. doi: 10.1136/jcp.51.2.96. PMID: 9602680Free PMC Article

Diagnosis

Are we managing our patients correctly following treatment for cervical glandular intraepithelial neoplasia? A review of practice at the Jessop Wing Colposcopy Unit.
Magro A, Lyon R, Ellis KM, Tidy JA, Macdonald MC, Palmer JE
Cytopathology 2021 Nov;32(6):758-765. Epub 2021 Sep 5 doi: 10.1111/cyt.13044. PMID: 34331788
Cervical glandular neoplasia referrals and the diagnosis of adenocarcinoma in situ: Correlating cytology, colposcopy findings, and clinical outcomes.
Nikolopoulos M, Athanasias P, Godfrey MAL, Nikolopoulos K, Maheshwari MK
Cytopathology 2021 Nov;32(6):751-757. Epub 2021 Jul 20 doi: 10.1111/cyt.13027. PMID: 34181788
Study of clinical diagnosis of cervical glandular intraepithelial neoplasia.
Yang S, Duan W, Kong W, Zhu L, Wu Y
Eur J Gynaecol Oncol 2016 Aug;37(4):539-542. PMID: 29894080
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
The pathology and management of endocervical glandular neoplasia.
El-Ghobashy AA, Shaaban AM, Herod J, Herrington CS
Int J Gynecol Cancer 2005 Jul-Aug;15(4):583-92. doi: 10.1111/j.1525-1438.2005.00113.x. PMID: 16014110

Prognosis

New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
The role of cervical cytology and colposcopy in detecting cervical glandular neoplasia.
Ullal A, Roberts M, Bulmer JN, Mathers ME, Wadehra V
Cytopathology 2009 Dec;20(6):359-66. Epub 2008 Jun 28 doi: 10.1111/j.1365-2303.2008.00566.x. PMID: 18557985
The pathology and management of endocervical glandular neoplasia.
El-Ghobashy AA, Shaaban AM, Herod J, Herrington CS
Int J Gynecol Cancer 2005 Jul-Aug;15(4):583-92. doi: 10.1111/j.1525-1438.2005.00113.x. PMID: 16014110
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ
J Clin Pathol 2005 May;58(5):525-34. doi: 10.1136/jcp.2004.018895. PMID: 15858126Free PMC Article
The expression of epithelial specific antigen in cervical intraepithelial neoplasia and adenocarcinoma.
Markaki S, Lazaris D, Papaspirou I, Paulou V
Eur J Gynaecol Oncol 2004;25(1):101-3. PMID: 15053074

Clinical prediction guides

Detection of occult endocervical glandular dysplasia in cervical conization specimens for squamous lesions.
Sopracordevole F, Clemente N, Alessandrini L, Di Giuseppe J, Cigolot F, Buttignol M, Ciavattini A, Canzonieri V
Pathol Res Pract 2017 Mar;213(3):210-216. Epub 2017 Jan 12 doi: 10.1016/j.prp.2016.12.015. PMID: 28214204
The role of cervical cytology and colposcopy in detecting cervical glandular neoplasia.
Ullal A, Roberts M, Bulmer JN, Mathers ME, Wadehra V
Cytopathology 2009 Dec;20(6):359-66. Epub 2008 Jun 28 doi: 10.1111/j.1365-2303.2008.00566.x. PMID: 18557985
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ
J Clin Pathol 2005 May;58(5):525-34. doi: 10.1136/jcp.2004.018895. PMID: 15858126Free PMC Article
The expression of epithelial specific antigen in cervical intraepithelial neoplasia and adenocarcinoma.
Markaki S, Lazaris D, Papaspirou I, Paulou V
Eur J Gynaecol Oncol 2004;25(1):101-3. PMID: 15053074
A clinical review of borderline glandular cells on cervical cytology.
Mohammed DK, Lavie O, de B Lopes A, Cross P, Monaghan JM
BJOG 2000 May;107(5):605-9. doi: 10.1111/j.1471-0528.2000.tb13300.x. PMID: 10826573

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