U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cervical Adenocarcinoma In Situ

MedGen UID:
91092
•Concept ID:
C0346203
•
Neoplastic Process
Synonyms: Adenocarcinoma in situ of cervix; Adenocarcinoma in situ of Cervix; Adenocarcinoma in situ of Cervix Uteri; Adenocarcinoma in situ of the Cervix; Adenocarcinoma in situ of the Cervix Uteri; Adenocarcinoma in situ of the Uterine Cervix; Adenocarcinoma in situ of Uterine Cervix; AIS - Adenocarcinoma in situ of cervix; Cervical ACIS (adenocarcinoma in situ); Cervix Adenocarcinoma in situ; Cervix Uteri Adenocarcinoma in situ; Uterine Cervix Adenocarcinoma in situ
SNOMED CT: Cervical ACIS (adenocarcinoma in situ) (254890008); AIS - Adenocarcinoma in situ of cervix (254890008); Adenocarcinoma in situ of cervix (254890008)

Definition

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Adenocarcinoma In Situ

Professional guidelines

PubMed

Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma.
Zhang RC, Vue NC, Obasi LU, Vogel RI, Subramanian AT, Khalifa MA, Reddy BR, Erickson BK
J Low Genit Tract Dis 2021 Oct 1;25(4):267-269. doi: 10.1097/LGT.0000000000000618. PMID: 34265818Free PMC Article
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Incidence and evaluation of an AGUS Papanicolaou smear in primary care.
Valdini A, Vaccaro C, Pechinsky G, Abernathy V
J Am Board Fam Pract 2001 May-Jun;14(3):172-7. PMID: 11355048

Recent clinical studies

Etiology

Conservative Treatment for Cervical Adenocarcinoma In Situ: Long-Term Results.
Monti E, Somigliana E, Alberico D, Boero V, Iorio M, Di Loreto E, Dell'acqua A, Liverani CA
J Low Genit Tract Dis 2022 Oct 1;26(4):293-297. Epub 2022 Aug 3 doi: 10.1097/LGT.0000000000000688. PMID: 35917498
Cervical adenocarcinoma in situ during pregnancy and subsequent fertility-sparing therapy challenge.
Sánchez-Cuerda C, Cuadra M, Gámir S, Lobo P, Elices M, Cabrera Y
Int J Gynaecol Obstet 2022 Jul;158(1):21-26. Epub 2021 Oct 23 doi: 10.1002/ijgo.13948. PMID: 34559882
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Cervical adenocarcinoma in situ: Human papillomavirus types and incidence trends in five states, 2008-2015.
Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Saadeh K, Pemmaraju M, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER; HPV-IMPACT Working Group
Int J Cancer 2020 Feb 1;146(3):810-818. Epub 2019 May 6 doi: 10.1002/ijc.32340. PMID: 30980692Free PMC Article
Cervical adenocarcinoma in situ.
Hopkins MP, Roberts JA, Schmidt RW
Obstet Gynecol 1988 Jun;71(6 Pt 1):842-4. PMID: 3285263

Diagnosis

Cervical adenocarcinoma in situ during pregnancy and subsequent fertility-sparing therapy challenge.
Sánchez-Cuerda C, Cuadra M, Gámir S, Lobo P, Elices M, Cabrera Y
Int J Gynaecol Obstet 2022 Jul;158(1):21-26. Epub 2021 Oct 23 doi: 10.1002/ijgo.13948. PMID: 34559882
Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma.
Zhang RC, Vue NC, Obasi LU, Vogel RI, Subramanian AT, Khalifa MA, Reddy BR, Erickson BK
J Low Genit Tract Dis 2021 Oct 1;25(4):267-269. doi: 10.1097/LGT.0000000000000618. PMID: 34265818Free PMC Article
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Cervical adenocarcinoma in situ: Human papillomavirus types and incidence trends in five states, 2008-2015.
Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Saadeh K, Pemmaraju M, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER; HPV-IMPACT Working Group
Int J Cancer 2020 Feb 1;146(3):810-818. Epub 2019 May 6 doi: 10.1002/ijc.32340. PMID: 30980692Free PMC Article
Cervical adenocarcinoma in situ.
Hopkins MP, Roberts JA, Schmidt RW
Obstet Gynecol 1988 Jun;71(6 Pt 1):842-4. PMID: 3285263

Therapy

Comparison of the safety between cervical conization and hysterectomy for patients with cervical adenocarcinoma in situ.
Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Excisional treatment comparison for in situ endocervical adenocarcinoma (EXCISE): A phase 2 pilot randomized controlled trial to compare histopathological margin status, specimen size and fragmentation after loop electrosurgical excision procedure and cold knife cone biopsy.
Cohen PA, Leung Y, Anderson L, van der Griend R, Chivers P, Bilic S, Bittinger S, Brand A, Bulsara MK, Codde J, Eva L, Farrell L, Harker D, Herbst U, Jeffares S, Loh D, McNally O, Mohan GR, Nicholson T, Powell A, Salfinger SG, Simcock B, Stewart C, Silvers J, Stockler MR, Sykes P, Stoyles P, Tan A, Tan AL, Wrede CDH
Gynecol Oncol 2020 Dec;159(3):623-629. Epub 2020 Oct 5 doi: 10.1016/j.ygyno.2020.09.053. PMID: 33032824
Cervical adenocarcinoma in situ: Human papillomavirus types and incidence trends in five states, 2008-2015.
Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Saadeh K, Pemmaraju M, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER; HPV-IMPACT Working Group
Int J Cancer 2020 Feb 1;146(3):810-818. Epub 2019 May 6 doi: 10.1002/ijc.32340. PMID: 30980692Free PMC Article
Excisional treatment in women with cervical adenocarcinoma in situ (AIS): a prospective randomised controlled non-inferiority trial to compare AIS persistence/recurrence after loop electrosurgical excision procedure with cold knife cone biopsy: protocol for a pilot study.
Cohen PA, Brand A, Sykes P, Wrede DCH, McNally O, Eva L, Rao A, Campion M, Stockler M, Powell A, Codde J, Bulsara MK, Anderson L, Leung Y, Farrell L, Stoyles P
BMJ Open 2017 Aug 28;7(8):e017576. doi: 10.1136/bmjopen-2017-017576. PMID: 28851799Free PMC Article
Recurrent invasive adenocarcinoma after hysterectomy for cervical adenocarcinoma in situ.
Krivak TC, Retherford B, Voskuil S, Rose GS, Alagoz T
Gynecol Oncol 2000 May;77(2):334-5. doi: 10.1006/gyno.2000.5761. PMID: 10785491

Prognosis

Follow-up Findings in Postconservative Treatment Surveillance for Women With Cervical Adenocarcinoma In Situ.
Upadhyay Baskota S, Wang T, Zhao C
J Low Genit Tract Dis 2021 Jan 1;25(1):38-42. doi: 10.1097/LGT.0000000000000579. PMID: 33284146
Cervical adenocarcinoma in situ: Human papillomavirus types and incidence trends in five states, 2008-2015.
Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Saadeh K, Pemmaraju M, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER; HPV-IMPACT Working Group
Int J Cancer 2020 Feb 1;146(3):810-818. Epub 2019 May 6 doi: 10.1002/ijc.32340. PMID: 30980692Free PMC Article
Risk of persistent and recurrent cervical neoplasia following incidentally detected adenocarcinoma in situ.
Munro A, Codde J, Spilsbury K, Steel N, Stewart CJ, Salfinger SG, Tan J, Mohan GR, Leung Y, Semmens JB, O'Leary P, Williams V, Cohen PA
Am J Obstet Gynecol 2017 Mar;216(3):272.e1-272.e7. Epub 2016 Nov 28 doi: 10.1016/j.ajog.2016.11.1044. PMID: 27908632
Cervical adenocarcinoma in situ: a systematic review of therapeutic options and predictors of persistent or recurrent disease.
Krivak TC, Rose GS, McBroom JW, Carlson JW, Winter WE 3rd, Kost ER
Obstet Gynecol Surv 2001 Sep;56(9):567-75. doi: 10.1097/00006254-200109000-00023. PMID: 11524622
Cervical adenocarcinoma in situ.
Hopkins MP, Roberts JA, Schmidt RW
Obstet Gynecol 1988 Jun;71(6 Pt 1):842-4. PMID: 3285263

Clinical prediction guides

Follow-up Findings in Postconservative Treatment Surveillance for Women With Cervical Adenocarcinoma In Situ.
Upadhyay Baskota S, Wang T, Zhao C
J Low Genit Tract Dis 2021 Jan 1;25(1):38-42. doi: 10.1097/LGT.0000000000000579. PMID: 33284146
RANZCOG Fellows' adherence to guidelines following cytological prediction of cervical adenocarcinoma-in-situ: Cause for concern?
Powell A, Cohen PA, Spilsbury K, Steel N, Blomfield P
Aust N Z J Obstet Gynaecol 2019 Apr;59(2):294-300. Epub 2018 Oct 4 doi: 10.1111/ajo.12886. PMID: 30284744
Predictors of invasive adenocarcinoma after conization for cervical adenocarcinoma in situ.
ElMasri WM, Walts AE, Chiang A, Walsh CS
Gynecol Oncol 2012 Jun;125(3):589-93. Epub 2012 Mar 9 doi: 10.1016/j.ygyno.2012.03.005. PMID: 22410327
Cervical adenocarcinoma in situ: a systematic review of therapeutic options and predictors of persistent or recurrent disease.
Krivak TC, Rose GS, McBroom JW, Carlson JW, Winter WE 3rd, Kost ER
Obstet Gynecol Surv 2001 Sep;56(9):567-75. doi: 10.1097/00006254-200109000-00023. PMID: 11524622
Cervical adenocarcinoma in situ.
Hopkins MP, Roberts JA, Schmidt RW
Obstet Gynecol 1988 Jun;71(6 Pt 1):842-4. PMID: 3285263

Recent systematic reviews

Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis.
Jiang Y, Chen C, Li L
PLoS One 2017;12(1):e0170587. Epub 2017 Jan 26 doi: 10.1371/journal.pone.0170587. PMID: 28125627Free PMC Article
Cervical adenocarcinoma in situ: a systematic review of therapeutic options and predictors of persistent or recurrent disease.
Krivak TC, Rose GS, McBroom JW, Carlson JW, Winter WE 3rd, Kost ER
Obstet Gynecol Surv 2001 Sep;56(9):567-75. doi: 10.1097/00006254-200109000-00023. PMID: 11524622

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...