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Ovarian clear cell malignant adenofibroma

MedGen UID:
384483
•Concept ID:
C2075522
•
Neoplastic Process
Synonyms: Ovarian Clear Cell Adenocarcinofibroma; ovarian clear cell adenocarcinofibroma; Ovarian Clear Cell Malignant Adenofibroma; ovarian clear cell malignant adenofibroma
 
Monarch Initiative: MONDO:0003922

Definition

A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. The epithelial component is characterized by the presence of malignant epithelial cells with clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian clear cell malignant adenofibroma

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Recent clinical studies

Etiology

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma.
Kawabata A, Yanaihara N, Nagata C, Saito M, Noguchi D, Takenaka M, Iida Y, Takano H, Yamada K, Iwamoto M, Kiyokawa T, Okamoto A
Gynecol Oncol 2017 Sep;146(3):609-614. Epub 2017 Jun 30 doi: 10.1016/j.ygyno.2017.06.027. PMID: 28673661
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822
Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma.
Roth LM, Langley FA, Fox H, Wheeler JE, Czernobilsky B
Cancer 1984 Mar 1;53(5):1156-63. doi: 10.1002/1097-0142(19840301)53:5<1156::aid-cncr2820530522>3.0.co;2-2. PMID: 6692303

Diagnosis

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Therapy

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Ovarian endometriosis associated with carcinoma and sarcoma: case report.
Boruban MC, Jaishuen A, Sirisabya N, Li Y, Zheng HG, Deavers MT, Kavanagh JJ
Eur J Gynaecol Oncol 2008;29(4):393-6. PMID: 18714578

Prognosis

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
ARID1A expression in ovarian clear cell carcinoma with an adenofibromatous component.
Nishikimi K, Kiyokawa T, Tate S, Iwamoto M, Shozu M
Histopathology 2015 Dec;67(6):866-71. Epub 2015 Jun 7 doi: 10.1111/his.12721. PMID: 25913291
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Clinical prediction guides

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma.
Kawabata A, Yanaihara N, Nagata C, Saito M, Noguchi D, Takenaka M, Iida Y, Takano H, Yamada K, Iwamoto M, Kiyokawa T, Okamoto A
Gynecol Oncol 2017 Sep;146(3):609-614. Epub 2017 Jun 30 doi: 10.1016/j.ygyno.2017.06.027. PMID: 28673661
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy.
Chen R, Zhou H, Zhang Y
Gynecol Endocrinol 2013 Mar;29(3):216-8. Epub 2012 Nov 16 doi: 10.3109/09513590.2012.736555. PMID: 23153077
Ovarian clear cell adenofibroma of borderline malignancy. A case report.
Katsube Y, Fujiwara H, Tanioka Y, Imajo M, Fujiwara A
Hiroshima J Med Sci 1989 Jun;38(2):87-90. PMID: 2793520

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