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Vulvar eccrine adenocarcinoma

MedGen UID:
384495
•Concept ID:
C2202743
•
Neoplastic Process
Synonyms: eccrine carcinoma of mammalian vulva; mammalian vulva eccrine carcinoma; Vulvar Eccrine Adenocarcinoma; vulvar eccrine adenocarcinoma
 
Monarch Initiative: MONDO:0003861

Definition

An eccrine adenocarcinoma that arises from the sweat glands in the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar eccrine adenocarcinoma

Professional guidelines

PubMed

Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients.
Konstantinova AM, Shelekhova KV, Stewart CJ, Spagnolo DV, Kutzner H, Kacerovska D, Plaza JA, Suster S, Bouda J, Pavlovsky M, Kyrpychova L, Michal M, Guenova E, Kazakov DV
Am J Dermatopathol 2016 Nov;38(11):802-808. doi: 10.1097/DAD.0000000000000552. PMID: 26863064

Recent clinical studies

Etiology

Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors(✰).
Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903
Vulval hidradenoma papilliferum: a clinical and dermoscopic study.
Tosti G, Salvini C, Barisani A, Grazi R, Pirola S, Cantisani C, Vaccari S, Madnani N
Clin Exp Dermatol 2020 Dec;45(8):1035-1039. Epub 2020 Oct 6 doi: 10.1111/ced.14254. PMID: 32356582
Vulvar adnexal lesions: a 32-year, single-institution review from Massachusetts General Hospital.
Baker GM, Selim MA, Hoang MP
Arch Pathol Lab Med 2013 Sep;137(9):1237-46. doi: 10.5858/arpa.2012-0434-OA. PMID: 23991738

Diagnosis

Vulval hidradenoma papilliferum: a clinical and dermoscopic study.
Tosti G, Salvini C, Barisani A, Grazi R, Pirola S, Cantisani C, Vaccari S, Madnani N
Clin Exp Dermatol 2020 Dec;45(8):1035-1039. Epub 2020 Oct 6 doi: 10.1111/ced.14254. PMID: 32356582
Vulvar eccrine porocarcinoma: report of a case and literature review.
Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2017;58(4):1611-1616. PMID: 29556664
Eccrine porocarcinoma of the vulva: a case report and review of the literature.
Fujimine-Sato A, Toyoshima M, Shigeta S, Toki A, Kuno T, Sato I, Watanabe M, Niikura H, Yaegashi N
J Med Case Rep 2016 Nov 10;10(1):319. doi: 10.1186/s13256-016-1106-1. PMID: 27832810Free PMC Article
Eccrine porocarcinoma of the vulva: a case report and review of literature.
Adegboyega PA
Int J Gynecol Pathol 2011 Jan;30(1):95-100. doi: 10.1097/PGP.0b013e3181ea11b1. PMID: 21131825
Vulvar sweat gland carcinomas.
Wick MR, Goellner JR, Wolfe JT 3rd, Su WP
Arch Pathol Lab Med 1985 Jan;109(1):43-7. PMID: 2982338

Therapy

Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report.
Ramirez Y, Fellegara G, Bugiani M
Int J Surg Pathol 2012 Oct;20(5):515-8. Epub 2011 Nov 21 doi: 10.1177/1066896911428738. PMID: 22108500
Cytoreductive combination chemotherapy for regionally advanced unresectable extramammary Paget carcinoma.
Voigt H, Bassermann R, Nathrath W
Cancer 1992 Aug 1;70(3):704-8. doi: 10.1002/1097-0142(19920801)70:3<704::aid-cncr2820700327>3.0.co;2-5. PMID: 1320453

Prognosis

Vulvar eccrine porocarcinoma: report of a case and literature review.
Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2017;58(4):1611-1616. PMID: 29556664
Eccrine porocarcinoma of the vulva: a case report and review of the literature.
Fujimine-Sato A, Toyoshima M, Shigeta S, Toki A, Kuno T, Sato I, Watanabe M, Niikura H, Yaegashi N
J Med Case Rep 2016 Nov 10;10(1):319. doi: 10.1186/s13256-016-1106-1. PMID: 27832810Free PMC Article
Syringocystadenocarcinoma Papilliferum In Situ-Like Changes in Extramammary Paget Disease: A Report of 11 Cases.
Konstantinova AM, Kacerovska D, Stewart CJ, Szepe P, Pitha J, Sulc M, Bencik V, Michal M, Shideler B, Kerl K, Kazakov DV
Am J Dermatopathol 2016 Dec;38(12):882-886. doi: 10.1097/DAD.0000000000000554. PMID: 26863065
Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients.
Konstantinova AM, Shelekhova KV, Stewart CJ, Spagnolo DV, Kutzner H, Kacerovska D, Plaza JA, Suster S, Bouda J, Pavlovsky M, Kyrpychova L, Michal M, Guenova E, Kazakov DV
Am J Dermatopathol 2016 Nov;38(11):802-808. doi: 10.1097/DAD.0000000000000552. PMID: 26863064

Clinical prediction guides

Vulvar eccrine porocarcinoma: report of a case and literature review.
Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2017;58(4):1611-1616. PMID: 29556664
Expression of mucin core proteins in extramammary Paget's disease.
Yoshii N, Kitajima S, Yonezawa S, Matsukita S, Setoyama M, Kanzaki T
Pathol Int 2002 May-Jun;52(5-6):390-9. doi: 10.1046/j.1440-1827.2002.01364.x. PMID: 12100522
Mammary and extramammary Paget's disease: expression of Ca 15-3, Ka-93, Ca 19-9 and CD44 in Paget cells and adjacent normal skin.
Tsuji T
Br J Dermatol 1995 Jan;132(1):7-13. doi: 10.1111/j.1365-2133.1995.tb08617.x. PMID: 7538778
Mammary-like glands of the vulva and their disorders.
van der Putte SC
Int J Gynecol Pathol 1994 Apr;13(2):150-60. doi: 10.1097/00004347-199404000-00009. PMID: 8005737
Anogenital "sweat" glands. Histology and pathology of a gland that may mimic mammary glands.
van der Putte SC
Am J Dermatopathol 1991 Dec;13(6):557-67. PMID: 1666822

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