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FLT3 Juxtamembrane Domain Point Mutation

MedGen UID:
385039
Concept ID:
C2348500
Cell or Molecular Dysfunction
Synonym: FLT3-JM-PM Mutation

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFLT3 Juxtamembrane Domain Point Mutation

Professional guidelines

PubMed

Mosquera Orgueira A, Bao Pérez L, Mosquera Torre A, Peleteiro Raíndo A, Cid López M, Díaz Arias JÁ, Ferreiro Ferro R, Antelo Rodríguez B, González Pérez MS, Albors Ferreiro M, Alonso Vence N, Pérez Encinas MM, Bello López JL, Martinelli G, Cerchione C
Minerva Med 2020 Oct;111(5):427-442. Epub 2020 Sep 21 doi: 10.23736/S0026-4806.20.06989-X. PMID: 32955823
Qiu QC, Wang C, Bao XB, Yang J, Shen HJ, Ding ZX, Liu H, He J, Yao H, Chen SN, Li Z, Xue SL, Liu SB
Hematology 2018 Apr;23(3):131-138. Epub 2017 Sep 6 doi: 10.1080/10245332.2017.1372248. PMID: 28876197
Small D
Hematology Am Soc Hematol Educ Program 2006:178-84. doi: 10.1182/asheducation-2006.1.178. PMID: 17124058

Recent clinical studies

Etiology

Mosquera Orgueira A, Bao Pérez L, Mosquera Torre A, Peleteiro Raíndo A, Cid López M, Díaz Arias JÁ, Ferreiro Ferro R, Antelo Rodríguez B, González Pérez MS, Albors Ferreiro M, Alonso Vence N, Pérez Encinas MM, Bello López JL, Martinelli G, Cerchione C
Minerva Med 2020 Oct;111(5):427-442. Epub 2020 Sep 21 doi: 10.23736/S0026-4806.20.06989-X. PMID: 32955823
Meshinchi S, Alonzo TA, Stirewalt DL, Zwaan M, Zimmerman M, Reinhardt D, Kaspers GJ, Heerema NA, Gerbing R, Lange BJ, Radich JP
Blood 2006 Dec 1;108(12):3654-61. Epub 2006 Aug 15 doi: 10.1182/blood-2006-03-009233. PMID: 16912228Free PMC Article
Kiyoi H, Naoe T
Int J Hematol 2006 May;83(4):301-8. doi: 10.1532/IJH97.06071. PMID: 16757428
Kiyoi H, Yanada M, Ozekia K
Int J Hematol 2005 Aug;82(2):85-92. doi: 10.1532/IJH97.05066. PMID: 16146837
Kang HJ, Hong SH, Kim IH, Park BK, Han KS, Cho HI, Shin HY, Ahn HS
Leuk Res 2005 Jun;29(6):617-23. Epub 2005 Jan 21 doi: 10.1016/j.leukres.2004.11.006. PMID: 15863200

Diagnosis

Ge SS, Qiu QC, Dai HP, Shen XD, Wu TM, Du JH, Wan CL, Shen HJ, Wu DP, Xue SL, Liu SB
Br J Haematol 2023 Aug;202(3):539-549. Epub 2023 May 28 doi: 10.1111/bjh.18877. PMID: 37246158
Mosquera Orgueira A, Bao Pérez L, Mosquera Torre A, Peleteiro Raíndo A, Cid López M, Díaz Arias JÁ, Ferreiro Ferro R, Antelo Rodríguez B, González Pérez MS, Albors Ferreiro M, Alonso Vence N, Pérez Encinas MM, Bello López JL, Martinelli G, Cerchione C
Minerva Med 2020 Oct;111(5):427-442. Epub 2020 Sep 21 doi: 10.23736/S0026-4806.20.06989-X. PMID: 32955823
Nguyen B, Williams AB, Young DJ, Ma H, Li L, Levis M, Brown P, Small D
Oncotarget 2017 Feb 14;8(7):10931-10944. doi: 10.18632/oncotarget.14539. PMID: 28077790Free PMC Article
Small D
Hematology Am Soc Hematol Educ Program 2006:178-84. doi: 10.1182/asheducation-2006.1.178. PMID: 17124058
Choudhary C, Schwäble J, Brandts C, Tickenbrock L, Sargin B, Kindler T, Fischer T, Berdel WE, Müller-Tidow C, Serve H
Blood 2005 Jul 1;106(1):265-73. Epub 2005 Mar 15 doi: 10.1182/blood-2004-07-2942. PMID: 15769897

Therapy

Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Recher C, Yoon SS, Maeda Y, Hosono N, Onozawa M, Kato T, Kim HJ, Hasabou N, Nuthethi R, Tiu R, Levis MJ
Transplant Cell Ther 2023 Apr;29(4):265.e1-265.e10. Epub 2022 Dec 13 doi: 10.1016/j.jtct.2022.12.006. PMID: 36526260Free PMC Article
Kiyoi H, Kawashima N, Ishikawa Y
Cancer Sci 2020 Feb;111(2):312-322. Epub 2019 Dec 30 doi: 10.1111/cas.14274. PMID: 31821677Free PMC Article
Larrosa-Garcia M, Baer MR
Mol Cancer Ther 2017 Jun;16(6):991-1001. doi: 10.1158/1535-7163.MCT-16-0876. PMID: 28576946Free PMC Article
Antar A, Otrock ZK, El-Cheikh J, Kharfan-Dabaja MA, Battipaglia G, Mahfouz R, Mohty M, Bazarbachi A
Bone Marrow Transplant 2017 Mar;52(3):344-351. Epub 2016 Oct 24 doi: 10.1038/bmt.2016.251. PMID: 27775694
Small D
Hematology Am Soc Hematol Educ Program 2006:178-84. doi: 10.1182/asheducation-2006.1.178. PMID: 17124058

Prognosis

Ge SS, Qiu QC, Dai HP, Shen XD, Wu TM, Du JH, Wan CL, Shen HJ, Wu DP, Xue SL, Liu SB
Br J Haematol 2023 Aug;202(3):539-549. Epub 2023 May 28 doi: 10.1111/bjh.18877. PMID: 37246158
Kiyoi H, Kawashima N, Ishikawa Y
Cancer Sci 2020 Feb;111(2):312-322. Epub 2019 Dec 30 doi: 10.1111/cas.14274. PMID: 31821677Free PMC Article
Ustun C, DeRemer DL, Jillella AP, Bhalla KN
Expert Opin Investig Drugs 2009 Oct;18(10):1445-56. doi: 10.1517/13543780903179278. PMID: 19671038
Zheng R, Small D
Leuk Lymphoma 2005 Dec;46(12):1679-87. doi: 10.1080/10428190500261740. PMID: 16263569
Kiyoi H, Yanada M, Ozekia K
Int J Hematol 2005 Aug;82(2):85-92. doi: 10.1532/IJH97.05066. PMID: 16146837

Clinical prediction guides

Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Recher C, Yoon SS, Maeda Y, Hosono N, Onozawa M, Kato T, Kim HJ, Hasabou N, Nuthethi R, Tiu R, Levis MJ
Transplant Cell Ther 2023 Apr;29(4):265.e1-265.e10. Epub 2022 Dec 13 doi: 10.1016/j.jtct.2022.12.006. PMID: 36526260Free PMC Article
Antar A, Otrock ZK, El-Cheikh J, Kharfan-Dabaja MA, Battipaglia G, Mahfouz R, Mohty M, Bazarbachi A
Bone Marrow Transplant 2017 Mar;52(3):344-351. Epub 2016 Oct 24 doi: 10.1038/bmt.2016.251. PMID: 27775694
Mattison RJ, Ostler KR, Locke FL, Godley LA
Rev Recent Clin Trials 2007 May;2(2):135-41. doi: 10.2174/157488707780599320. PMID: 18473998
Choudhary C, Schwäble J, Brandts C, Tickenbrock L, Sargin B, Kindler T, Fischer T, Berdel WE, Müller-Tidow C, Serve H
Blood 2005 Jul 1;106(1):265-73. Epub 2005 Mar 15 doi: 10.1182/blood-2004-07-2942. PMID: 15769897
Andersson A, Johansson B, Lassen C, Mitelman F, Billström R, Fioretos T
Eur J Haematol 2004 May;72(5):307-13. doi: 10.1111/j.1600-0609.2004.00225.x. PMID: 15059064

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