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FLT3 Gene Mutation

MedGen UID:
926841
•Concept ID:
C4289309
•
Cell or Molecular Dysfunction
Synonyms: CD135 Gene Mutation; FLK2 Gene Mutation; FLT3 Gene Mutant; FLT3 Mutation; FMS-Related Tyrosine Kinase 3 Gene Mutation

Definition

A change in the nucleotide sequence of the FLT3 gene. [from NCI]

Professional guidelines

PubMed

Advancing treatment of acute myeloid leukemia: the future of FLT3 inhibitors.
Elshoury A, Przespolewski A, Baron J, Wang ES
Expert Rev Anticancer Ther 2019 Mar;19(3):273-286. Epub 2019 Feb 6 doi: 10.1080/14737140.2019.1573679. PMID: 30681373
Treatment of Acute Myeloid Leukemia with the FLT3 Gene Mutation.
Best-Aguilera C, Rodrigo Gómez-Vázquez O, Elizabeth Guzmán-Hernández A, Monserrat Rojas-Sotelo R
Curr Oncol Rep 2017 Mar;19(3):21. doi: 10.1007/s11912-017-0573-x. PMID: 28283965

Recent clinical studies

Etiology

Outcome of Childhood Acute Myeloid Leukemia With FLT3-ITD Mutation: The Experience of Children's Cancer Hospital Egypt, 2007-17.
Semary SF, Hammad M, Soliman S, Yassen D, Gamal M, Albeltagy D, Hamdy N, Mahmoud S
Clin Lymphoma Myeloma Leuk 2020 Aug;20(8):e529-e541. Epub 2020 Apr 21 doi: 10.1016/j.clml.2020.04.011. PMID: 32473792
Treatment of Acute Myeloid Leukemia with the FLT3 Gene Mutation.
Best-Aguilera C, Rodrigo Gómez-Vázquez O, Elizabeth Guzmán-Hernández A, Monserrat Rojas-Sotelo R
Curr Oncol Rep 2017 Mar;19(3):21. doi: 10.1007/s11912-017-0573-x. PMID: 28283965
FLT3 Gene Mutation Profile and Prognosis in Adult Acute Myeloid Leukemia.
Azari-Yam A, Tavakkoly-Bazzaz J, Semnani Y, Davoudi-Dehaghani E, Ghodssi-Ghassemabadi R, Kianfar S, Saadat A, Masoudifard M, Yaghmaie M, Alimoghaddam K, Ghavamzadeh A, Zeinali S
Clin Lab 2016 Oct 1;62(10):2011-2017. doi: 10.7754/Clin.Lab.2016.160324. PMID: 28164537
Nucleophosmin gene mutations in acute myeloid leukemia.
Chen W, Rassidakis GZ, Medeiros LJ
Arch Pathol Lab Med 2006 Nov;130(11):1687-92. doi: 10.5858/2006-130-1687-NGMIAM. PMID: 17076533
Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy.
Tiesmeier J, Müller-Tidow C, Westermann A, Czwalinna A, Hoffmann M, Krauter J, Heil G, Ganser A, Serve H, Verbeek W
Leuk Res 2004 Oct;28(10):1069-74. doi: 10.1016/j.leukres.2004.02.009. PMID: 15289019

Diagnosis

Midostaurin-induced Sweet syndrome in a patient with FLT3-ITD-positive AML.
Alkassis S, Rizwan A, Daoud L, Chi J
BMJ Case Rep 2021 Aug 20;14(8) doi: 10.1136/bcr-2021-243615. PMID: 34417240Free PMC Article
Co-occurrence of PML-RARA gene fusion, chromosome 8 trisomy, and FLT3 ITD mutation in a young female patient with de novo acute myeloid leukemia and early death: A CARE case report.
Tripon F, Crauciuc GA, Bogliş A, Moldovan V, Sándor-Kéri J, Benedek IJ, Trifa AP, Bănescu C
Medicine (Baltimore) 2020 Apr;99(14):e19730. doi: 10.1097/MD.0000000000019730. PMID: 32243411Free PMC Article
FLT3 Gene Mutation Profile and Prognosis in Adult Acute Myeloid Leukemia.
Azari-Yam A, Tavakkoly-Bazzaz J, Semnani Y, Davoudi-Dehaghani E, Ghodssi-Ghassemabadi R, Kianfar S, Saadat A, Masoudifard M, Yaghmaie M, Alimoghaddam K, Ghavamzadeh A, Zeinali S
Clin Lab 2016 Oct 1;62(10):2011-2017. doi: 10.7754/Clin.Lab.2016.160324. PMID: 28164537
Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy.
Tiesmeier J, Müller-Tidow C, Westermann A, Czwalinna A, Hoffmann M, Krauter J, Heil G, Ganser A, Serve H, Verbeek W
Leuk Res 2004 Oct;28(10):1069-74. doi: 10.1016/j.leukres.2004.02.009. PMID: 15289019
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R
Blood 1999 May 1;93(9):3074-80. PMID: 10216104

Therapy

Midostaurin-induced Sweet syndrome in a patient with FLT3-ITD-positive AML.
Alkassis S, Rizwan A, Daoud L, Chi J
BMJ Case Rep 2021 Aug 20;14(8) doi: 10.1136/bcr-2021-243615. PMID: 34417240Free PMC Article
Advancing treatment of acute myeloid leukemia: the future of FLT3 inhibitors.
Elshoury A, Przespolewski A, Baron J, Wang ES
Expert Rev Anticancer Ther 2019 Mar;19(3):273-286. Epub 2019 Feb 6 doi: 10.1080/14737140.2019.1573679. PMID: 30681373
Treatment of Acute Myeloid Leukemia with the FLT3 Gene Mutation.
Best-Aguilera C, Rodrigo Gómez-Vázquez O, Elizabeth Guzmán-Hernández A, Monserrat Rojas-Sotelo R
Curr Oncol Rep 2017 Mar;19(3):21. doi: 10.1007/s11912-017-0573-x. PMID: 28283965
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R
Blood 1999 May 1;93(9):3074-80. PMID: 10216104

Prognosis

Targeting Molecular Signaling Pathways and Cytokine Responses to Modulate c-MYC in Acute Myeloid Leukemia.
Gu K, May HA, Kang MH
Front Biosci (Schol Ed) 2024 Sep 14;16(3):15. doi: 10.31083/j.fbs1603015. PMID: 39344393
Identification of a novel mutation of the FLT3 gene located on the juxtamembrane domain from acute myeloid leukemia patients.
Arwanih EY, Rinaldi I, Wanandi SI, Louisa M
Mol Biol Rep 2024 Jul 29;51(1):867. doi: 10.1007/s11033-024-09790-1. PMID: 39073493
Advancing treatment of acute myeloid leukemia: the future of FLT3 inhibitors.
Elshoury A, Przespolewski A, Baron J, Wang ES
Expert Rev Anticancer Ther 2019 Mar;19(3):273-286. Epub 2019 Feb 6 doi: 10.1080/14737140.2019.1573679. PMID: 30681373
FLT3 Gene Mutation Profile and Prognosis in Adult Acute Myeloid Leukemia.
Azari-Yam A, Tavakkoly-Bazzaz J, Semnani Y, Davoudi-Dehaghani E, Ghodssi-Ghassemabadi R, Kianfar S, Saadat A, Masoudifard M, Yaghmaie M, Alimoghaddam K, Ghavamzadeh A, Zeinali S
Clin Lab 2016 Oct 1;62(10):2011-2017. doi: 10.7754/Clin.Lab.2016.160324. PMID: 28164537
Nucleophosmin gene mutations in acute myeloid leukemia.
Chen W, Rassidakis GZ, Medeiros LJ
Arch Pathol Lab Med 2006 Nov;130(11):1687-92. doi: 10.5858/2006-130-1687-NGMIAM. PMID: 17076533

Clinical prediction guides

Co-occurrence of PML-RARA gene fusion, chromosome 8 trisomy, and FLT3 ITD mutation in a young female patient with de novo acute myeloid leukemia and early death: A CARE case report.
Tripon F, Crauciuc GA, Bogliş A, Moldovan V, Sándor-Kéri J, Benedek IJ, Trifa AP, Bănescu C
Medicine (Baltimore) 2020 Apr;99(14):e19730. doi: 10.1097/MD.0000000000019730. PMID: 32243411Free PMC Article
CD19/CD22 chimeric antigen receptor T-cell therapy for refractory acute B-cell lymphoblastic leukemia with FLT3-ITD mutations.
Jin A, Feng J, Wei G, Wu W, Yang L, Xu H, Zhang Y, Cui J, Chang AH, Hu Y, Huang H
Bone Marrow Transplant 2020 Apr;55(4):717-721. Epub 2020 Jan 31 doi: 10.1038/s41409-020-0807-7. PMID: 32005917
De novo acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): a clinicopathologic and cytogenetic study of an entity recently added to the WHO classification.
Sun J, Konoplev SN, Wang X, Cui W, Chen SS, Medeiros LJ, Lin P
Mod Pathol 2011 Mar;24(3):384-9. Epub 2010 Nov 26 doi: 10.1038/modpathol.2010.210. PMID: 21113141
Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype.
Konoplev S, Rassidakis GZ, Estey E, Kantarjian H, Liakou CI, Huang X, Xiao L, Andreeff M, Konopleva M, Medeiros LJ
Cancer 2007 Mar 15;109(6):1152-6. doi: 10.1002/cncr.22510. PMID: 17315232
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R
Blood 1999 May 1;93(9):3074-80. PMID: 10216104

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