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Stage 4 chronic kidney disease

MedGen UID:
389224
Concept ID:
C2317473
Disease or Syndrome
Synonyms: Chronic kidney disease stage 4; Chronic Kidney Disease, Stage 4; CKD stage 4; Severe Kidney Disease; Severe Renal Disease
SNOMED CT: Chronic kidney disease stage 4 (431857002); CKD stage 4 (431857002)
 
HPO: HP:0012626

Definition

A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage 4 chronic kidney disease

Professional guidelines

PubMed

Zhou W, Herwald SE, Uppot RN, Arellano RS
J Vasc Interv Radiol 2018 Dec;29(12):1685-1691. Epub 2018 Oct 5 doi: 10.1016/j.jvir.2018.06.021. PMID: 30297311
Ko SY, Choe WH
Clin Mol Hepatol 2018 Dec;24(4):351-357. Epub 2018 Mar 16 doi: 10.3350/cmh.2017.0063. PMID: 29544240Free PMC Article
Fabrizi F, Martin P, Messa P
Kidney Int 2016 May;89(5):988-994. Epub 2016 Mar 11 doi: 10.1016/j.kint.2016.01.011. PMID: 27083277

Curated

UK NICE Guideline NG203, Chronic kidney disease: assessment and management, 2021

Recent clinical studies

Etiology

Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, Dickinson JH, Ouyang F, Tu W
N Engl J Med 2021 Dec 30;385(27):2507-2519. Epub 2021 Nov 5 doi: 10.1056/NEJMoa2110730. PMID: 34739197Free PMC Article
Cherney DZI, Ferrannini E, Umpierrez GE, Peters AL, Rosenstock J, Carroll AK, Lapuerta P, Banks P, Agarwal R
Diabetes Obes Metab 2021 Dec;23(12):2632-2642. Epub 2021 Aug 20 doi: 10.1111/dom.14513. PMID: 34338408
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Sharma P, Bari K
Adv Chronic Kidney Dis 2015 Sep;22(5):404-11. doi: 10.1053/j.ackd.2015.06.001. PMID: 26311603Free PMC Article
Miller PD
Bone 2011 Jul;49(1):77-81. Epub 2011 Jan 11 doi: 10.1016/j.bone.2010.12.024. PMID: 21232648

Diagnosis

Kanbour S, Balaji A, Chae K, Mathioudakis N
BMJ Case Rep 2022 Jul 26;15(7) doi: 10.1136/bcr-2021-245890. PMID: 35882435Free PMC Article
San Norberto EM, Revilla Á, Fernández-Urbón A, Gómez-Giralda B, Taylor JH, Vaquero C
Int Angiol 2021 Dec;40(6):528-536. Epub 2021 Sep 13 doi: 10.23736/S0392-9590.21.04698-8. PMID: 34515450
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Sharma P, Bari K
Adv Chronic Kidney Dis 2015 Sep;22(5):404-11. doi: 10.1053/j.ackd.2015.06.001. PMID: 26311603Free PMC Article
Miller PD
Bone 2011 Jul;49(1):77-81. Epub 2011 Jan 11 doi: 10.1016/j.bone.2010.12.024. PMID: 21232648

Therapy

Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, Dickinson JH, Ouyang F, Tu W
N Engl J Med 2021 Dec 30;385(27):2507-2519. Epub 2021 Nov 5 doi: 10.1056/NEJMoa2110730. PMID: 34739197Free PMC Article
Cherney DZI, Ferrannini E, Umpierrez GE, Peters AL, Rosenstock J, Carroll AK, Lapuerta P, Banks P, Agarwal R
Diabetes Obes Metab 2021 Dec;23(12):2632-2642. Epub 2021 Aug 20 doi: 10.1111/dom.14513. PMID: 34338408
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Sharma P, Bari K
Adv Chronic Kidney Dis 2015 Sep;22(5):404-11. doi: 10.1053/j.ackd.2015.06.001. PMID: 26311603Free PMC Article
Miller PD
Bone 2011 Jul;49(1):77-81. Epub 2011 Jan 11 doi: 10.1016/j.bone.2010.12.024. PMID: 21232648

Prognosis

Jalal K, Charest A, Wu X, Quigg RJ, Chang S
BMC Nephrol 2024 Feb 14;25(1):55. doi: 10.1186/s12882-024-03478-1. PMID: 38355500Free PMC Article
Kanbour S, Balaji A, Chae K, Mathioudakis N
BMJ Case Rep 2022 Jul 26;15(7) doi: 10.1136/bcr-2021-245890. PMID: 35882435Free PMC Article
Jose MD, Raj R, Jose K, Kitsos A, Saunder T, McKercher C, Radford J
Med J Aust 2022 Feb 21;216(3):140-146. Epub 2021 Dec 5 doi: 10.5694/mja2.51361. PMID: 34866191
San Norberto EM, Revilla Á, Fernández-Urbón A, Gómez-Giralda B, Taylor JH, Vaquero C
Int Angiol 2021 Dec;40(6):528-536. Epub 2021 Sep 13 doi: 10.23736/S0392-9590.21.04698-8. PMID: 34515450
Sharma P, Bari K
Adv Chronic Kidney Dis 2015 Sep;22(5):404-11. doi: 10.1053/j.ackd.2015.06.001. PMID: 26311603Free PMC Article

Clinical prediction guides

San Norberto EM, Revilla Á, Fernández-Urbón A, Gómez-Giralda B, Taylor JH, Vaquero C
Int Angiol 2021 Dec;40(6):528-536. Epub 2021 Sep 13 doi: 10.23736/S0392-9590.21.04698-8. PMID: 34515450
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Alqallaf A, Alam A, Sapir-Pichhadze R, Ghali P, Cantarovich M
Exp Clin Transplant 2021 Mar;19(3):231-236. doi: 10.6002/ect.2020.0557. PMID: 33719946
Miller PD
Bone 2011 Jul;49(1):77-81. Epub 2011 Jan 11 doi: 10.1016/j.bone.2010.12.024. PMID: 21232648
O'Neill WC, Sigrist MK, McIntyre CW
Nephrol Dial Transplant 2010 Jan;25(1):187-91. Epub 2009 Jul 24 doi: 10.1093/ndt/gfp362. PMID: 19633093Free PMC Article

Recent systematic reviews

Doulamis IP, Tzani A, Kampaktsis PN, Kaneko T, Tang GHL
Cardiovasc Revasc Med 2022 May;38:29-35. Epub 2021 Jul 23 doi: 10.1016/j.carrev.2021.07.021. PMID: 34334337

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG203, Chronic kidney disease: assessment and management, 2021

    Consumer resources

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