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Non-Neoplastic Kidney Disorder

MedGen UID:
235388
Concept ID:
C1335036
Disease or Syndrome
Synonym: Non-Neoplastic Renal Disorder

Definition

A non-neoplastic disorder that affects the renal parenchyma and/or renal pelvis. Representative examples include glomerulonephritis and pyelonephritis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Kidney Disorder

Professional guidelines

PubMed

Lan W, Yang L, Tan X
Mol Cell Biochem 2024 Oct;479(10):2523-2543. Epub 2023 Oct 25 doi: 10.1007/s11010-023-04871-4. PMID: 37880443
Godoy MC, Viswanathan C, Marchiori E, Truong MT, Benveniste MF, Rossi S, Marom EM
Br J Radiol 2012 Sep;85(1017):1226-35. Epub 2012 May 2 doi: 10.1259/bjr/54532316. PMID: 22553298Free PMC Article
Langford CA, Klippel JH, Balow JE, James SP, Sneller MC
Ann Intern Med 1998 Jun 15;128(12 Pt 1):1021-8. doi: 10.7326/0003-4819-128-12_part_1-199806150-00012. PMID: 9625665

Recent clinical studies

Etiology

Abedi-Ardekani B, Nasrollahzadeh D, Egevad L, Banks RE, Vasudev N, Holcatova I, Povysil C, Foretova L, Janout V, Mates D, Jinga V, Petrescu A, Milosavljevic S, Ognjanovic M, Ognjanovic S, Viksna J, Warren AY, Lathrop M, Riazalhosseini Y, Carreira C, Chanudet E, McKay J, Brennan P, Scélo G
Virchows Arch 2021 Jun;478(6):1099-1107. Epub 2021 Jan 5 doi: 10.1007/s00428-020-02986-3. PMID: 33403511Free PMC Article
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Chang A, Finelli A, Berns JS, Rosner M
Adv Chronic Kidney Dis 2014 Jan;21(1):91-5. doi: 10.1053/j.ackd.2013.09.003. PMID: 24359991
Yaqoob M, Bell GM
Ren Fail 1994;16(4):425-34. doi: 10.3109/08860229409045074. PMID: 7938751

Diagnosis

de Haan K, Zhang Y, Zuckerman JE, Liu T, Sisk AE, Diaz MFP, Jen KY, Nobori A, Liou S, Zhang S, Riahi R, Rivenson Y, Wallace WD, Ozcan A
Nat Commun 2021 Aug 12;12(1):4884. doi: 10.1038/s41467-021-25221-2. PMID: 34385460Free PMC Article
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
Gulati M, Cheng J, Loo JT, Skalski M, Malhi H, Duddalwar V
Clin Imaging 2018 Sep-Oct;51:133-154. Epub 2018 Feb 16 doi: 10.1016/j.clinimag.2018.02.012. PMID: 29477809
Chang A, Finelli A, Berns JS, Rosner M
Adv Chronic Kidney Dis 2014 Jan;21(1):91-5. doi: 10.1053/j.ackd.2013.09.003. PMID: 24359991
Surabhi VR, Menias C, Prasad SR, Patel AH, Nagar A, Dalrymple NC
Radiographics 2008 Jul-Aug;28(4):1005-17. doi: 10.1148/rg.284075157. PMID: 18635626

Therapy

Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Li L, Lau WL, Rhee CM, Harley K, Kovesdy CP, Sim JJ, Jacobsen S, Chang A, Landman J, Kalantar-Zadeh K
Nat Rev Nephrol 2014 Mar;10(3):135-45. Epub 2014 Jan 14 doi: 10.1038/nrneph.2013.273. PMID: 24419566
Bonsib SM, Pei Y
Adv Anat Pathol 2010 Jul;17(4):235-50. doi: 10.1097/PAP.0b013e3181e3c02d. PMID: 20574169
Yaqoob M, Bell GM
Ren Fail 1994;16(4):425-34. doi: 10.3109/08860229409045074. PMID: 7938751
Starzl TE, Esquivel C, Gordon R, Todo S
Transplant Proc 1987 Aug;19(4):3230-5. PMID: 3303488Free PMC Article

Prognosis

González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Devuyst F, Kazakou P, Balériaux D, Alexopoulou O, Burniat A, Salenave S, Chanson P, Corvilain B, Maiter D
Eur J Endocrinol 2020 Jul 1;181(3):95-105. doi: 10.1530/EJE-20-0058. PMID: 32530258
Brandina R, Moreira Leite KR, Gregório EP, Fernandes KBP, Srougi M
Urology 2017 Feb;100:158-162. Epub 2016 Oct 8 doi: 10.1016/j.urology.2016.09.041. PMID: 27725235
Li L, Lau WL, Rhee CM, Harley K, Kovesdy CP, Sim JJ, Jacobsen S, Chang A, Landman J, Kalantar-Zadeh K
Nat Rev Nephrol 2014 Mar;10(3):135-45. Epub 2014 Jan 14 doi: 10.1038/nrneph.2013.273. PMID: 24419566
Bonsib SM, Pei Y
Adv Anat Pathol 2010 Jul;17(4):235-50. doi: 10.1097/PAP.0b013e3181e3c02d. PMID: 20574169

Clinical prediction guides

Mozaffari MS
J Pharmacol Exp Ther 2023 Dec;387(3):277-287. Epub 2023 Sep 28 doi: 10.1124/jpet.123.001846. PMID: 37770199
Abedi-Ardekani B, Nasrollahzadeh D, Egevad L, Banks RE, Vasudev N, Holcatova I, Povysil C, Foretova L, Janout V, Mates D, Jinga V, Petrescu A, Milosavljevic S, Ognjanovic M, Ognjanovic S, Viksna J, Warren AY, Lathrop M, Riazalhosseini Y, Carreira C, Chanudet E, McKay J, Brennan P, Scélo G
Virchows Arch 2021 Jun;478(6):1099-1107. Epub 2021 Jan 5 doi: 10.1007/s00428-020-02986-3. PMID: 33403511Free PMC Article
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Li L, Lau WL, Rhee CM, Harley K, Kovesdy CP, Sim JJ, Jacobsen S, Chang A, Landman J, Kalantar-Zadeh K
Nat Rev Nephrol 2014 Mar;10(3):135-45. Epub 2014 Jan 14 doi: 10.1038/nrneph.2013.273. PMID: 24419566
Bonsib SM, Pei Y
Adv Anat Pathol 2010 Jul;17(4):235-50. doi: 10.1097/PAP.0b013e3181e3c02d. PMID: 20574169

Recent systematic reviews

Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A
Crit Rev Toxicol 2024 Sep;54(8):485-617. Epub 2024 Aug 16 doi: 10.1080/10408444.2024.2362985. PMID: 39150724
Cazzaniga G, Rossi M, Eccher A, Girolami I, L'Imperio V, Van Nguyen H, Becker JU, Bueno García MG, Sbaraglia M, Dei Tos AP, Gambaro G, Pagni F
J Nephrol 2024 Jan;37(1):65-76. Epub 2023 Sep 28 doi: 10.1007/s40620-023-01775-w. PMID: 37768550Free PMC Article
Guerrero-Pérez F, Marengo AP, Vilarrasa N, Vidal N, Ruiz-Roig N, Sánchez-Fernández JJ, Torres-Díaz A, Sanmillán JL, Pérez-Maraver M, Villabona C
Hormones (Athens) 2023 Jun;22(2):199-210. Epub 2023 Jan 25 doi: 10.1007/s42000-023-00432-y. PMID: 36695986

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