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Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

MedGen UID:
389485
Concept ID:
C2347539
Neoplastic Process

Definition

An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults. [from NCI]

Professional guidelines

PubMed

Ragusa D, Dijkhuis L, Pina C, Tosi S
Biosci Rep 2023 Jan 31;43(1) doi: 10.1042/BSR20220489. PMID: 36622782Free PMC Article
El Fakih R, Jabbour E, Ravandi F, Hassanein M, Anjum F, Ahmed S, Kantarjian H
Am J Hematol 2018 Feb;93(2):286-295. Epub 2017 Oct 31 doi: 10.1002/ajh.24926. PMID: 28971501
Grimwade D, Moorman A, Hills R, Wheatley K, Walker H, Harrison G, Harrison Ch, Goldstone A, Burnett A; NCRI Adult Leukaemia Working Party
Ann Hematol 2004;83 Suppl 1:S45-8. doi: 10.1007/s00277-004-0849-8. PMID: 15124668

Recent clinical studies

Etiology

Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Padmakumar D, Chandraprabha VR, Gopinath P, Vimala Devi ART, Anitha GRJ, Sreelatha MM, Padmakumar A, Sreedharan H
Leuk Res 2021 Dec;111:106727. Epub 2021 Oct 16 doi: 10.1016/j.leukres.2021.106727. PMID: 34700049
Begna KH, Kittur J, Yui J, Gangat N, Patnaik MM, Al-Kali A, Elliott MA, Hogan WJ, Litzow MR, Hook CC, Wolanskyj AP, Howard MT, Hanson CA, Ketterling RP, Pardanani AD, Tefferi A
Br J Haematol 2021 Nov;195(3):413-416. Epub 2021 Aug 3 doi: 10.1111/bjh.17742. PMID: 34346084
Faber ZJ, Chen X, Gedman AL, Boggs K, Cheng J, Ma J, Radtke I, Chao JR, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, Cai Z, Mulder H, Wu G, Edmonson M, Rusch M, Qu C, Li Y, Vadodaria B, Wang J, Hedlund E, Cao X, Yergeau D, Nakitandwe J, Pounds SB, Shurtleff S, Fulton RS, Fulton LL, Easton J, Parganas E, Pui CH, Rubnitz JE, Ding L, Mardis ER, Wilson RK, Gruber TA, Mullighan CG, Schlenk RF, Paschka P, Döhner K, Döhner H, Bullinger L, Zhang J, Klco JM, Downing JR
Nat Genet 2016 Dec;48(12):1551-1556. Epub 2016 Oct 31 doi: 10.1038/ng.3709. PMID: 27798625Free PMC Article
Aquino VM
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):50-8. doi: 10.1067/mps.2002.121791. PMID: 11951090

Diagnosis

Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Moorman AV, Barretta E, Butler ER, Ward EJ, Twentyman K, Kirkwood AA, Enshaei A, Schwab C, Creasey T, Leongamornlert D, Papaemmanuil E, Patrick P, Clifton-Hadley L, Patel B, Menne T, McMillan AK, Harrison CJ, Rowntree CJ, Marks DI, Fielding AK
Leukemia 2022 Mar;36(3):625-636. Epub 2021 Oct 16 doi: 10.1038/s41375-021-01448-2. PMID: 34657128Free PMC Article
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article
Liu Q, Liu N, Zang S, Liu H, Wang P, Ji C, Sun X
PLoS One 2014;9(6):e98853. Epub 2014 Jun 5 doi: 10.1371/journal.pone.0098853. PMID: 24901999Free PMC Article
Aquino VM
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):50-8. doi: 10.1067/mps.2002.121791. PMID: 11951090

Therapy

Ranieri R, Pianigiani G, Sciabolacci S, Perriello VM, Marra A, Cardinali V, Pierangeli S, Milano F, Gionfriddo I, Brunetti L, Martelli MP, Falini B
Leukemia 2022 Oct;36(10):2351-2367. Epub 2022 Aug 25 doi: 10.1038/s41375-022-01666-2. PMID: 36008542Free PMC Article
Begna KH, Kittur J, Yui J, Gangat N, Patnaik MM, Al-Kali A, Elliott MA, Hogan WJ, Litzow MR, Hook CC, Wolanskyj AP, Howard MT, Hanson CA, Ketterling RP, Pardanani AD, Tefferi A
Br J Haematol 2021 Nov;195(3):413-416. Epub 2021 Aug 3 doi: 10.1111/bjh.17742. PMID: 34346084
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Aquino VM
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):50-8. doi: 10.1067/mps.2002.121791. PMID: 11951090

Prognosis

Padmakumar D, Chandraprabha VR, Gopinath P, Vimala Devi ART, Anitha GRJ, Sreelatha MM, Padmakumar A, Sreedharan H
Leuk Res 2021 Dec;111:106727. Epub 2021 Oct 16 doi: 10.1016/j.leukres.2021.106727. PMID: 34700049
Begna KH, Kittur J, Yui J, Gangat N, Patnaik MM, Al-Kali A, Elliott MA, Hogan WJ, Litzow MR, Hook CC, Wolanskyj AP, Howard MT, Hanson CA, Ketterling RP, Pardanani AD, Tefferi A
Br J Haematol 2021 Nov;195(3):413-416. Epub 2021 Aug 3 doi: 10.1111/bjh.17742. PMID: 34346084
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Aquino VM
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):50-8. doi: 10.1067/mps.2002.121791. PMID: 11951090

Clinical prediction guides

Bataller A, Kantarjian H, Bazinet A, Kadia T, Daver N, DiNardo CD, Borthakur G, Loghavi S, Patel K, Tang G, Sasaki K, Short NJ, Yilmaz M, Issa GC, Alvarado Y, Montalban-Bravo G, Maiti A, Abbas HA, Takahashi K, Pierce S, Jabbour E, Garcia-Manero G, Ravandi F
Haematologica 2024 Nov 1;109(11):3543-3556. doi: 10.3324/haematol.2024.285057. PMID: 38695144Free PMC Article
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article
Costa AR, Belangero SI, Melaragno MI, Chauffaille Mde L
Med Oncol 2012 Sep;29(3):2083-7. Epub 2011 Nov 25 doi: 10.1007/s12032-011-0108-5. PMID: 22116774
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736

Recent systematic reviews

Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914
Tie R, Zhang T, Fu H, Wang L, Wang Y, He Y, Wang B, Zhu N, Fu S, Lai X, Shi J, Huang H
PLoS One 2014;9(6):e93353. Epub 2014 Jun 17 doi: 10.1371/journal.pone.0093353. PMID: 24936645Free PMC Article

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