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Inflammatory bowel disease 11(IBD11)

MedGen UID:
393069
•Concept ID:
C2674051
•
Disease or Syndrome
Synonym: IBD11
 
Monarch Initiative: MONDO:0008617
OMIM®: 191390

Definition

An inflammatory bowel disease that has material basis in variation in the chromosome region 7q22. [from MONDO]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
•Concept ID:
C0000737
•
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
See: Feature record | Search on this feature
Weight loss
MedGen UID:
853198
•Concept ID:
C1262477
•
Finding
Reduction of total body weight.
See: Feature record | Search on this feature
Diarrhea
MedGen UID:
8360
•Concept ID:
C0011991
•
Sign or Symptom
Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.
See: Feature record | Search on this feature
Hematochezia
MedGen UID:
5481
•Concept ID:
C0018932
•
Disease or Syndrome
The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.
See: Feature record | Search on this feature
Inflammation of the large intestine
MedGen UID:
662273
•Concept ID:
C0578878
•
Disease or Syndrome
Inflammation, or an inflammatory state in the large intestine.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.
Bisgaard TH, Allin KH, Keefer L, Ananthakrishnan AN, Jess T
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):717-726. Epub 2022 Jun 22 doi: 10.1038/s41575-022-00634-6. PMID: 35732730
Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions.
Keshteli AH, Madsen KL, Dieleman LA
Nutrients 2019 Jun 30;11(7) doi: 10.3390/nu11071498. PMID: 31262022Free PMC Article
Crohn's Disease: Diagnosis and Management.
Veauthier B, Hornecker JR
Am Fam Physician 2018 Dec 1;98(11):661-669. PMID: 30485038

Recent clinical studies

Etiology

Characteristics and outcomes of acute colitis diagnosed on cross-sectional imaging presenting via the emergency department in an Irish academic medical centre.
O'Connell J, Keohane S, McGreal-Bellone A, McDonagh P, Naimimohasses S, Kennedy U, Dunne C, Hartery K, Larkin J, MacCarthy F, Meaney J, McKiernan S, Norris S, O'Toole D, Kevans D
Ir J Med Sci 2020 Aug;189(3):1115-1121. Epub 2020 Jan 10 doi: 10.1007/s11845-019-02162-w. PMID: 31925651
Long-term results after endoanal advancement flap repair for fistulas-in-ano. How important is the aetiology?
Goos M, Manegold P, Grüneberger M, Thomusch O, Ruf G
Int J Colorectal Dis 2015 Mar;30(3):413-9. Epub 2015 Feb 6 doi: 10.1007/s00384-015-2144-7. PMID: 25652877
Clinical features of ileal pouch-anal anastomosis in African American patients with underlying ulcerative colitis.
Moore L, Tang L, Lopez R, Shen B
Aliment Pharmacol Ther 2009 Aug 15;30(4):385-91. Epub 2009 May 28 doi: 10.1111/j.1365-2036.2009.04054.x. PMID: 19485976
Fluoroscopic and CT enteroclysis in children: initial experience, technical feasibility, and utility.
Brown S, Applegate KE, Sandrasegaran K, Jennings SG, Garrett J, Skantharajah A, Maglinte DT
Pediatr Radiol 2008 May;38(5):497-510. Epub 2008 Feb 7 doi: 10.1007/s00247-008-0754-8. PMID: 18256816
Gender differences in presentation and course of disease in pediatric patients with Crohn disease.
Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Winter HS, Baldassano RN, Gold BD, Abramson O, Smith T, Cohen SA, Heyman MB
Pediatrics 2007 Dec;120(6):e1418-25. doi: 10.1542/peds.2007-0905. PMID: 18055660

Diagnosis

Lessons Learned From the Clinical Presentation of Common Variable Immunodeficiency Disorders: A Systematic Review and Meta-Analysis.
Janssen LMA, van der Flier M, de Vries E
Front Immunol 2021;12:620709. Epub 2021 Mar 23 doi: 10.3389/fimmu.2021.620709. PMID: 33833753Free PMC Article
Characteristics and outcomes of acute colitis diagnosed on cross-sectional imaging presenting via the emergency department in an Irish academic medical centre.
O'Connell J, Keohane S, McGreal-Bellone A, McDonagh P, Naimimohasses S, Kennedy U, Dunne C, Hartery K, Larkin J, MacCarthy F, Meaney J, McKiernan S, Norris S, O'Toole D, Kevans D
Ir J Med Sci 2020 Aug;189(3):1115-1121. Epub 2020 Jan 10 doi: 10.1007/s11845-019-02162-w. PMID: 31925651
Clinical features of pyoderma gangrenosum and current diagnostic trends.
Hadi A, Lebwohl M
J Am Acad Dermatol 2011 May;64(5):950-4. Epub 2011 Feb 3 doi: 10.1016/j.jaad.2010.01.049. PMID: 21292348
Fluoroscopic and CT enteroclysis in children: initial experience, technical feasibility, and utility.
Brown S, Applegate KE, Sandrasegaran K, Jennings SG, Garrett J, Skantharajah A, Maglinte DT
Pediatr Radiol 2008 May;38(5):497-510. Epub 2008 Feb 7 doi: 10.1007/s00247-008-0754-8. PMID: 18256816
Gender differences in presentation and course of disease in pediatric patients with Crohn disease.
Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Winter HS, Baldassano RN, Gold BD, Abramson O, Smith T, Cohen SA, Heyman MB
Pediatrics 2007 Dec;120(6):e1418-25. doi: 10.1542/peds.2007-0905. PMID: 18055660

Therapy

Long-term results after endoanal advancement flap repair for fistulas-in-ano. How important is the aetiology?
Goos M, Manegold P, Grüneberger M, Thomusch O, Ruf G
Int J Colorectal Dis 2015 Mar;30(3):413-9. Epub 2015 Feb 6 doi: 10.1007/s00384-015-2144-7. PMID: 25652877
Clinical features of ileal pouch-anal anastomosis in African American patients with underlying ulcerative colitis.
Moore L, Tang L, Lopez R, Shen B
Aliment Pharmacol Ther 2009 Aug 15;30(4):385-91. Epub 2009 May 28 doi: 10.1111/j.1365-2036.2009.04054.x. PMID: 19485976
Fluoroscopic and CT enteroclysis in children: initial experience, technical feasibility, and utility.
Brown S, Applegate KE, Sandrasegaran K, Jennings SG, Garrett J, Skantharajah A, Maglinte DT
Pediatr Radiol 2008 May;38(5):497-510. Epub 2008 Feb 7 doi: 10.1007/s00247-008-0754-8. PMID: 18256816

Prognosis

Lessons Learned From the Clinical Presentation of Common Variable Immunodeficiency Disorders: A Systematic Review and Meta-Analysis.
Janssen LMA, van der Flier M, de Vries E
Front Immunol 2021;12:620709. Epub 2021 Mar 23 doi: 10.3389/fimmu.2021.620709. PMID: 33833753Free PMC Article
Long-term results after endoanal advancement flap repair for fistulas-in-ano. How important is the aetiology?
Goos M, Manegold P, Grüneberger M, Thomusch O, Ruf G
Int J Colorectal Dis 2015 Mar;30(3):413-9. Epub 2015 Feb 6 doi: 10.1007/s00384-015-2144-7. PMID: 25652877
Clinical features of ileal pouch-anal anastomosis in African American patients with underlying ulcerative colitis.
Moore L, Tang L, Lopez R, Shen B
Aliment Pharmacol Ther 2009 Aug 15;30(4):385-91. Epub 2009 May 28 doi: 10.1111/j.1365-2036.2009.04054.x. PMID: 19485976
Fluoroscopic and CT enteroclysis in children: initial experience, technical feasibility, and utility.
Brown S, Applegate KE, Sandrasegaran K, Jennings SG, Garrett J, Skantharajah A, Maglinte DT
Pediatr Radiol 2008 May;38(5):497-510. Epub 2008 Feb 7 doi: 10.1007/s00247-008-0754-8. PMID: 18256816
Gender differences in presentation and course of disease in pediatric patients with Crohn disease.
Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Winter HS, Baldassano RN, Gold BD, Abramson O, Smith T, Cohen SA, Heyman MB
Pediatrics 2007 Dec;120(6):e1418-25. doi: 10.1542/peds.2007-0905. PMID: 18055660

Clinical prediction guides

Characteristics and outcomes of acute colitis diagnosed on cross-sectional imaging presenting via the emergency department in an Irish academic medical centre.
O'Connell J, Keohane S, McGreal-Bellone A, McDonagh P, Naimimohasses S, Kennedy U, Dunne C, Hartery K, Larkin J, MacCarthy F, Meaney J, McKiernan S, Norris S, O'Toole D, Kevans D
Ir J Med Sci 2020 Aug;189(3):1115-1121. Epub 2020 Jan 10 doi: 10.1007/s11845-019-02162-w. PMID: 31925651
Long-term results after endoanal advancement flap repair for fistulas-in-ano. How important is the aetiology?
Goos M, Manegold P, Grüneberger M, Thomusch O, Ruf G
Int J Colorectal Dis 2015 Mar;30(3):413-9. Epub 2015 Feb 6 doi: 10.1007/s00384-015-2144-7. PMID: 25652877
Fluoroscopic and CT enteroclysis in children: initial experience, technical feasibility, and utility.
Brown S, Applegate KE, Sandrasegaran K, Jennings SG, Garrett J, Skantharajah A, Maglinte DT
Pediatr Radiol 2008 May;38(5):497-510. Epub 2008 Feb 7 doi: 10.1007/s00247-008-0754-8. PMID: 18256816

Recent systematic reviews

Lessons Learned From the Clinical Presentation of Common Variable Immunodeficiency Disorders: A Systematic Review and Meta-Analysis.
Janssen LMA, van der Flier M, de Vries E
Front Immunol 2021;12:620709. Epub 2021 Mar 23 doi: 10.3389/fimmu.2021.620709. PMID: 33833753Free PMC Article

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