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Monoclonal B-Cell Lymphocytosis

MedGen UID:
395902
•Concept ID:
C2698259
•
Neoplastic Process
Synonyms: MBL - monoclonal B-cell lymphocytosis; Monoclonal B-cell lymphocytosis
SNOMED CT: MBL - monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (789740004)

Definition

A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Monoclonal B-Cell Lymphocytosis

Professional guidelines

PubMed

Monoclonal B-cell Lymphocytosis - a review of diagnostic criteria, biology, natural history, and clinical management.
Tang C, Shen Y, Soosapilla A, Mulligan SP
Leuk Lymphoma 2022 Dec;63(12):2795-2806. Epub 2022 Jun 29 doi: 10.1080/10428194.2022.2092857. PMID: 35767361
Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management.
Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC
Leukemia 2010 Mar;24(3):512-20. Epub 2010 Jan 21 doi: 10.1038/leu.2009.287. PMID: 20090778Free PMC Article
Diagnostic criteria for monoclonal B-cell lymphocytosis.
Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N; International Familial CLL Consortium
Br J Haematol 2005 Aug;130(3):325-32. doi: 10.1111/j.1365-2141.2005.05550.x. PMID: 16042682

Recent clinical studies

Etiology

Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1.
Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?
Angelillo P, Capasso A, Ghia P, Scarfò L
Eur J Intern Med 2018 Dec;58:2-6. Epub 2018 Sep 26 doi: 10.1016/j.ejim.2018.09.006. PMID: 30268574
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?
Scarfò L, Dagklis A, Scielzo C, Fazi C, Ghia P
Semin Cancer Biol 2010 Dec;20(6):384-90. Epub 2010 Sep 15 doi: 10.1016/j.semcancer.2010.08.005. PMID: 20816789

Diagnosis

Characteristic bone marrow findings in patients with UBA1 somatic mutations and VEXAS syndrome.
Patel N, Dulau-Florea A, Calvo KR
Semin Hematol 2021 Oct;58(4):204-211. Epub 2021 Oct 22 doi: 10.1053/j.seminhematol.2021.10.007. PMID: 34802541
Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1.
Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Monoclonal B-cell lymphocytosis.
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Therapy

Immunophenotypic profile and clinical outcome of monoclonal B-cell lymphocytosis in kidney transplantation.
Alfano G, Fontana F, Colaci E, Franceschini E, Ligabue G, Messerotti A, Bettelli F, Grottola A, Gennari W, Potenza L, Guaraldi G, Mussini C, Luppi M, Cappelli G
Clin Transplant 2018 Aug;32(8):e13338. Epub 2018 Aug 26 doi: 10.1111/ctr.13338. PMID: 30074641
Monoclonal B-cell lymphocytosis; not the same as B-cell chronic lymphocytic leukaemia.
Svenningsen M, Herborg LL, Hokland P, Ludvigsen M
Dan Med J 2017 Dec;64(12) PMID: 29206098
Familial leukemias.
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Monoclonal B-cell lymphocytosis.
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229
Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies.
Vogt RF, Shim YK, Middleton DC, Buffler PA, Campolucci SS, Lybarger JA, Marti GE
Br J Haematol 2007 Dec;139(5):690-700. doi: 10.1111/j.1365-2141.2007.06861.x. PMID: 18021083

Prognosis

Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1.
Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Familial leukemias.
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Clinical aspects of monoclonal B-cell lymphocytosis.
Mowery YM, Lanasa MC
Cancer Control 2012 Jan;19(1):8-17. doi: 10.1177/107327481201900102. PMID: 22143058
Monoclonal B-cell lymphocytosis.
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Clinical prediction guides

Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Monoclonal B-cell lymphocytosis: a reappraisal of its clinical implications.
Molica S, Mauro FR, Molica M, Del Giudice I, Foà R
Leuk Lymphoma 2012 Sep;53(9):1660-5. Epub 2012 Mar 16 doi: 10.3109/10428194.2012.666542. PMID: 22335530
Clinical aspects of monoclonal B-cell lymphocytosis.
Mowery YM, Lanasa MC
Cancer Control 2012 Jan;19(1):8-17. doi: 10.1177/107327481201900102. PMID: 22143058
CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?
Scarfò L, Dagklis A, Scielzo C, Fazi C, Ghia P
Semin Cancer Biol 2010 Dec;20(6):384-90. Epub 2010 Sep 15 doi: 10.1016/j.semcancer.2010.08.005. PMID: 20816789

Recent systematic reviews

Chronic lymphocytic leukemia and autoimmunity: a systematic review.
Hodgson K, Ferrer G, Montserrat E, Moreno C
Haematologica 2011 May;96(5):752-61. Epub 2011 Jan 17 doi: 10.3324/haematol.2010.036152. PMID: 21242190Free PMC Article
Prevalence of monoclonal B-cell lymphocytosis: a systematic review.
Shim YK, Middleton DC, Caporaso NE, Rachel JM, Landgren O, Abbasi F, Raveche ES, Rawstron AC, Orfao A, Marti GE, Vogt RF
Cytometry B Clin Cytom 2010;78 Suppl 1(Suppl 1):S10-8. doi: 10.1002/cyto.b.20538. PMID: 20839330Free PMC Article

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