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Monoclonal B-Cell Lymphocytosis

MedGen UID:
395902
Concept ID:
C2698259
Neoplastic Process
Synonyms: MBL - monoclonal B-cell lymphocytosis; Monoclonal B-cell lymphocytosis
SNOMED CT: MBL - monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (789740004)

Definition

A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Monoclonal B-Cell Lymphocytosis

Professional guidelines

PubMed

Tang C, Shen Y, Soosapilla A, Mulligan SP
Leuk Lymphoma 2022 Dec;63(12):2795-2806. Epub 2022 Jun 29 doi: 10.1080/10428194.2022.2092857. PMID: 35767361
Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC
Leukemia 2010 Mar;24(3):512-20. Epub 2010 Jan 21 doi: 10.1038/leu.2009.287. PMID: 20090778Free PMC Article
Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N; International Familial CLL Consortium
Br J Haematol 2005 Aug;130(3):325-32. doi: 10.1111/j.1365-2141.2005.05550.x. PMID: 16042682

Recent clinical studies

Etiology

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Angelillo P, Capasso A, Ghia P, Scarfò L
Eur J Intern Med 2018 Dec;58:2-6. Epub 2018 Sep 26 doi: 10.1016/j.ejim.2018.09.006. PMID: 30268574
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Parikh SA, Kay NE, Shanafelt TD
Clin Adv Hematol Oncol 2013 Nov;11(11):720-9. PMID: 24896545

Diagnosis

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Nardi V, Kuo FC, Hasserjian RP
Am J Clin Pathol 2019 Aug 1;152(3):347-358. doi: 10.1093/ajcp/aqz079. PMID: 31305863
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Therapy

Wen YK
Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1502-1505. doi: 10.4103/1319-2442.248281. PMID: 30588987
Alfano G, Fontana F, Colaci E, Franceschini E, Ligabue G, Messerotti A, Bettelli F, Grottola A, Gennari W, Potenza L, Guaraldi G, Mussini C, Luppi M, Cappelli G
Clin Transplant 2018 Aug;32(8):e13338. Epub 2018 Aug 26 doi: 10.1111/ctr.13338. PMID: 30074641
Svenningsen M, Herborg LL, Hokland P, Ludvigsen M
Dan Med J 2017 Dec;64(12) PMID: 29206098
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Prognosis

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
D'Auria F, Valvano L, Rago L, Statuto T, Calice G, D'Arena G, Fusco V, Musto P
J Investig Med 2019 Apr;67(4):779-782. Epub 2019 Jan 11 doi: 10.1136/jim-2018-000902. PMID: 30635362
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Clinical prediction guides

Celis M, Navarro Y, Serrano N, Martínez D, Nieto W
Biomedica 2023 Dec 29;43(Sp. 3):66-78. doi: 10.7705/biomedica.7099. PMID: 38207149Free PMC Article
Oliva-Ariza G, Fuentes-Herrero B, Lecrevisse Q, Carbonell C, Pérez-Pons A, Torres-Valle A, Pozo J, Martín-Oterino JÁ, González-López Ó, López-Bernús A, Bernal-Ribes M, Belhassen-García M, Pérez-Escurza O, Pérez-Andrés M, Vazquez L, Hernández-Pérez G, García Palomo FJ, Leoz P, Costa-Alba P, Pérez-Losada E, Yeguas A, Santos Sánchez M, García-Blázquez M, Morán-Plata FJ, Damasceno D, Botafogo V, Muñoz-García N, Fluxa R, van Dongen JJM, Marcos M, Almeida J, Orfao A; ECRIN-M3 Consortium
Am J Hematol 2023 Dec;98(12):1909-1922. Epub 2023 Oct 4 doi: 10.1002/ajh.27119. PMID: 37792579
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Scarfò L, Dagklis A, Scielzo C, Fazi C, Ghia P
Semin Cancer Biol 2010 Dec;20(6):384-90. Epub 2010 Sep 15 doi: 10.1016/j.semcancer.2010.08.005. PMID: 20816789

Recent systematic reviews

Hodgson K, Ferrer G, Montserrat E, Moreno C
Haematologica 2011 May;96(5):752-61. Epub 2011 Jan 17 doi: 10.3324/haematol.2010.036152. PMID: 21242190Free PMC Article
Shim YK, Middleton DC, Caporaso NE, Rachel JM, Landgren O, Abbasi F, Raveche ES, Rawstron AC, Orfao A, Marti GE, Vogt RF
Cytometry B Clin Cytom 2010;78 Suppl 1(Suppl 1):S10-8. doi: 10.1002/cyto.b.20538. PMID: 20839330Free PMC Article

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