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Platelet aggregation, spontaneous

MedGen UID:
401406
•Concept ID:
C1868263
•
Disease or Syndrome
Synonym: Platelet Aggregation, Spontaneous
 
HPO: HP:0030403
Monarch Initiative: MONDO:0008253
OMIM®: 173400

Definition

Clumping together of platelets in the blood in a platelet aggregation test without addition of agents normally used to induce aggregation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatelet aggregation, spontaneous

Professional guidelines

PubMed

Platelet thrombospondin and glycoprotein IV abnormalities in patients with essential thrombocythemia: effect of alpha-interferon treatment.
Legrand C, Bellucci S, Disdier M, Edelman L, Tobelem G
Am J Hematol 1991 Dec;38(4):307-13. doi: 10.1002/ajh.2830380410. PMID: 1720925
Intraoperative management of patients with heparin-induced thrombocytopenia.
Kappa JR, Fisher CA, Todd B, Stenach N, Bell P, Campbell F, Ellison N, Addonizio VP
Ann Thorac Surg 1990 May;49(5):714-22; discussion 723. doi: 10.1016/0003-4975(90)90008-t. PMID: 1692679

Recent clinical studies

Etiology

Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton's Tyrosine Kinase.
Duan R, Goldmann L, Li Y, Weber C, Siess W, von Hundelshausen P
Int J Mol Sci 2021 Dec 22;23(1) doi: 10.3390/ijms23010076. PMID: 35008508Free PMC Article
Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim.
Al-Samkari H, Van Cott EM, Kuter DJ
Ann Hematol 2019 Mar;98(3):581-588. Epub 2018 Nov 17 doi: 10.1007/s00277-018-3556-6. PMID: 30446804
Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome.
Burke N, Flood K, Muellers S, Murray A, Dunne E, Cotter B, Dempsey M, Dicker P, Geary MP, Kenny D, Malone FD
Eur J Obstet Gynecol Reprod Biol 2016 Apr;199:132-6. Epub 2016 Feb 20 doi: 10.1016/j.ejogrb.2016.02.010. PMID: 26927895
Increased platelet reactivity in patients with late-stage metastatic cancer.
Cooke NM, Egan K, McFadden S, Grogan L, Breathnach OS, O'Leary J, Hennessy BT, Kenny D
Cancer Med 2013 Aug;2(4):564-70. Epub 2013 May 21 doi: 10.1002/cam4.86. PMID: 24156029Free PMC Article
Effect of erythropoietin therapy and withdrawal on blood coagulation and fibrinolysis in hemodialysis patients.
Taylor JE, Belch JJ, McLaren M, Henderson IS, Stewart WK
Kidney Int 1993 Jul;44(1):182-90. doi: 10.1038/ki.1993.229. PMID: 8355460

Diagnosis

Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim.
Al-Samkari H, Van Cott EM, Kuter DJ
Ann Hematol 2019 Mar;98(3):581-588. Epub 2018 Nov 17 doi: 10.1007/s00277-018-3556-6. PMID: 30446804

Therapy

Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim.
Al-Samkari H, Van Cott EM, Kuter DJ
Ann Hematol 2019 Mar;98(3):581-588. Epub 2018 Nov 17 doi: 10.1007/s00277-018-3556-6. PMID: 30446804
Effect of erythropoietin therapy and withdrawal on blood coagulation and fibrinolysis in hemodialysis patients.
Taylor JE, Belch JJ, McLaren M, Henderson IS, Stewart WK
Kidney Int 1993 Jul;44(1):182-90. doi: 10.1038/ki.1993.229. PMID: 8355460
Effect of lovastatin on hemorheology in type II hyperlipoproteinemia.
Koppensteiner R, Minar E, Ehringer H
Atherosclerosis 1990 Jul;83(1):53-8. doi: 10.1016/0021-9150(90)90130-b. PMID: 2390136
Heparin versus low molecular weight heparin K 2165 in chronic hemodialysis patients: a randomized cross-over study.
Borm JJ, Krediet R, Sturk A, ten Cate JW
Haemostasis 1986;16 Suppl 2:59-68. doi: 10.1159/000215582. PMID: 2943643

Prognosis

Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome.
Burke N, Flood K, Muellers S, Murray A, Dunne E, Cotter B, Dempsey M, Dicker P, Geary MP, Kenny D, Malone FD
Eur J Obstet Gynecol Reprod Biol 2016 Apr;199:132-6. Epub 2016 Feb 20 doi: 10.1016/j.ejogrb.2016.02.010. PMID: 26927895
Effect of lovastatin on hemorheology in type II hyperlipoproteinemia.
Koppensteiner R, Minar E, Ehringer H
Atherosclerosis 1990 Jul;83(1):53-8. doi: 10.1016/0021-9150(90)90130-b. PMID: 2390136

Clinical prediction guides

Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim.
Al-Samkari H, Van Cott EM, Kuter DJ
Ann Hematol 2019 Mar;98(3):581-588. Epub 2018 Nov 17 doi: 10.1007/s00277-018-3556-6. PMID: 30446804
Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome.
Burke N, Flood K, Muellers S, Murray A, Dunne E, Cotter B, Dempsey M, Dicker P, Geary MP, Kenny D, Malone FD
Eur J Obstet Gynecol Reprod Biol 2016 Apr;199:132-6. Epub 2016 Feb 20 doi: 10.1016/j.ejogrb.2016.02.010. PMID: 26927895
Assessment of spontaneous platelet aggregation using laser light scattering in healthy subjects: an attempt to standardize.
Suzuki S, Kudo H, Koyama T
Int J Lab Hematol 2014 Dec;36(6):676-85. Epub 2014 Mar 24 doi: 10.1111/ijlh.12208. PMID: 24661348
Effect of erythropoietin therapy and withdrawal on blood coagulation and fibrinolysis in hemodialysis patients.
Taylor JE, Belch JJ, McLaren M, Henderson IS, Stewart WK
Kidney Int 1993 Jul;44(1):182-90. doi: 10.1038/ki.1993.229. PMID: 8355460
Factors influencing platelet aggregation in whole blood.
Abbate R, Favilla S, Boddi M, Costanzo G, Prisco D
Am J Clin Pathol 1986 Jul;86(1):91-6. doi: 10.1093/ajcp/86.1.91. PMID: 3728385

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