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Gouty arthropathy

MedGen UID:
406
•Concept ID:
C0003868
•
Disease or Syndrome
Synonyms: Arthritides, Gouty; Arthritis, Gouty; Gouty Arthritides; Gouty Arthritis
SNOMED CT: Joints gout affected (170733007); Gouty arthropathy (190828008); Arthritis due to gout (48440001); Articular gout (48440001); Gouty arthritis (48440001)

Definition

Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular. Acute and chronic gouty arthritis are associated with accumulation of MONOSODIUM URATE in and around affected joints. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGouty arthropathy

Professional guidelines

PubMed

Gout: A Rapid Review of Presentation, Diagnosis and Management.
Badshah M, Nadeem I, Ahmed I, Naim T, Fanciullo J
S D Med 2024 Feb;77(2):81-86. PMID: 38986162
Management of gout by Moroccan rheumatologists: a Moroccan Society for Rheumatology National Survey.
Moulay Berkchi J, Rkain H, Benbrahim L, Aktaou S, Lazrak N, Faiz S, Ahid S, Abouqal R, Labzizi S, Ouzeddoun N, Oukerraj L, Hmamouchi I, Hajjaj-Hassouni N, Allali F
Rheumatol Int 2020 Sep;40(9):1399-1408. Epub 2020 May 23 doi: 10.1007/s00296-020-04599-0. PMID: 32447422
Treatment of hyperuricemia, gout and other crystalline arthritidies.
Lioté F
Reumatismo 2012 Jan 19;63(4):276-83. doi: 10.4081/reumatismo.2011.276. PMID: 22303534

Recent clinical studies

Etiology

At the crossroads of gout and psoriatic arthritis: "psout".
Felten R, Duret PM, Gottenberg JE, Spielmann L, Messer L
Clin Rheumatol 2020 May;39(5):1405-1413. Epub 2020 Feb 15 doi: 10.1007/s10067-020-04981-0. PMID: 32062768
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Hyperuricaemia: more than just a cause of gout?
Katsiki N, Karagiannis A, Athyros VG, Mikhailidis DP
J Cardiovasc Med (Hagerstown) 2013 Jun;14(6):397-402. doi: 10.2459/JCM.0b013e3283595adc. PMID: 23032963
Gout and hyperuricemia.
Chilappa CS, Aronow WS, Shapiro D, Sperber K, Patel U, Ash JY
Compr Ther 2010;36:3-13. PMID: 21229813
Axial gouty arthropathy.
Saketkoo LA, Robertson HJ, Dyer HR, Virk ZU, Ferreyro HR, Espinoza LR
Am J Med Sci 2009 Aug;338(2):140-6. doi: 10.1097/MAJ.0b013e3181a3dc14. PMID: 19680018

Diagnosis

Severe and Uncommon Features of Gouty Arthropathy.
Almeida DE, Costa E, Neves JS, Cerqueira M, Ribeiro AR
J Clin Rheumatol 2021 Oct 1;27(7):e253. doi: 10.1097/RHU.0000000000001385. PMID: 32332266
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Gouty arthropathy: Review of clinico-pathologic and imaging features.
Parathithasan N, Lee WK, Pianta M, Oon S, Perera W
J Med Imaging Radiat Oncol 2016 Feb;60(1):9-20. Epub 2015 Oct 5 doi: 10.1111/1754-9485.12356. PMID: 26439321
High-Resolution US of Rheumatologic Diseases.
Taljanovic MS, Melville DM, Gimber LH, Scalcione LR, Miller MD, Kwoh CK, Klauser AS
Radiographics 2015 Nov-Dec;35(7):2026-48. doi: 10.1148/rg.2015140250. PMID: 26562235
Axial gouty arthropathy.
Saketkoo LA, Robertson HJ, Dyer HR, Virk ZU, Ferreyro HR, Espinoza LR
Am J Med Sci 2009 Aug;338(2):140-6. doi: 10.1097/MAJ.0b013e3181a3dc14. PMID: 19680018

Therapy

Gout: A Rapid Review of Presentation, Diagnosis and Management.
Badshah M, Nadeem I, Ahmed I, Naim T, Fanciullo J
S D Med 2024 Feb;77(2):81-86. PMID: 38986162
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Treatment of hyperuricemia, gout and other crystalline arthritidies.
Lioté F
Reumatismo 2012 Jan 19;63(4):276-83. doi: 10.4081/reumatismo.2011.276. PMID: 22303534
Gout and hyperuricemia.
Chilappa CS, Aronow WS, Shapiro D, Sperber K, Patel U, Ash JY
Compr Ther 2010;36:3-13. PMID: 21229813
What do I need to know about gout?
Becker MA, Ruoff GE
J Fam Pract 2010 Jun;59(6 Suppl):S1-8. PMID: 20544070

Prognosis

Plasma adsorption in refractory chronic gouty arthritis flare: A case report.
Lei Y, Cui TJ, Wang XH, Zhang XM, Tang C, Zheng ZH
Front Immunol 2022;13:1045982. Epub 2022 Nov 24 doi: 10.3389/fimmu.2022.1045982. PMID: 36505444Free PMC Article
Pretreatment and Coadministration With Methotrexate Improved Durability of Pegloticase Response: An Observational, Proof-of-Concept Case Series.
Botson JK, Peterson J
J Clin Rheumatol 2022 Jan 1;28(1):e129-e134. doi: 10.1097/RHU.0000000000001639. PMID: 33044389Free PMC Article
Tophaceous gouty arthropathy of the lumbar spine.
Saripalli K, Baskar S
Clin Med (Lond) 2014 Dec;14(6):683-4. doi: 10.7861/clinmedicine.14-6-683. PMID: 25468860Free PMC Article
Hyperuricaemia: more than just a cause of gout?
Katsiki N, Karagiannis A, Athyros VG, Mikhailidis DP
J Cardiovasc Med (Hagerstown) 2013 Jun;14(6):397-402. doi: 10.2459/JCM.0b013e3283595adc. PMID: 23032963
Clinical outcome of tibiotalar arthrodesis utilizing the chevron technique.
Kopp FJ, Banks MA, Marcus RE
Foot Ankle Int 2004 Apr;25(4):225-30. doi: 10.1177/107110070402500406. PMID: 15132930

Clinical prediction guides

Pretreatment and Coadministration With Methotrexate Improved Durability of Pegloticase Response: An Observational, Proof-of-Concept Case Series.
Botson JK, Peterson J
J Clin Rheumatol 2022 Jan 1;28(1):e129-e134. doi: 10.1097/RHU.0000000000001639. PMID: 33044389Free PMC Article
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
The Unique Macroscopic Appearance of Gouty Arthritis of the Knee.
Mittl GS, Zuckerman JD
Bull Hosp Jt Dis (2013) 2015 Jul;73(3):210-2. PMID: 26535601
Bone erosions in patients with chronic gouty arthropathy are associated with tophi but not bone oedema or synovitis: new insights from a 3 T MRI study.
McQueen FM, Doyle A, Reeves Q, Gao A, Tsai A, Gamble GD, Curteis B, Williams M, Dalbeth N
Rheumatology (Oxford) 2014 Jan;53(1):95-103. Epub 2013 Sep 29 doi: 10.1093/rheumatology/ket329. PMID: 24080252
Atherogenic serum lipid profile is an independent predictor for gouty flares in patients with gouty arthropathy.
Mak A, Ho RC, Tan JY, Teng GG, Lahiri M, Lateef A, Vasoo S, Boey ML, Koh DR, Feng PH
Rheumatology (Oxford) 2009 Mar;48(3):262-5. Epub 2009 Jan 16 doi: 10.1093/rheumatology/ken471. PMID: 19151029

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