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Nasopharyngeal carcinoma, susceptibility to, 2(NPCA2)

MedGen UID:
413336
•Concept ID:
C2750548
•
Neoplastic Process
Synonym: Nasopharyngeal carcinoma 2
 
Monarch Initiative: MONDO:0008067
OMIM®: 161550

Definition

Nasopharyngeal carcinoma is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx (summary by Tse et al., 2009). For a general phenotypic description and a discussion of genetic heterogeneity of susceptibility to nasopharyngeal carcinoma, see NPCA1 (607107). [from OMIM]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
•Concept ID:
C0027651
•
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
See: Feature record | Search on this feature

Professional guidelines

PubMed

Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.
Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin X
Cell Genom 2024 Feb 14;4(2):100474. Epub 2024 Jan 9 doi: 10.1016/j.xgen.2023.100474. PMID: 38359790Free PMC Article
Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan.
Hsu SW, Gong CL, Hsu HM, Chao CC, Wang YC, Chang WS, Tsai YT, Shih LC, Tsai CW, Bau DT
Cancer Genomics Proteomics 2019 Jul-Aug;16(4):287-292. doi: 10.21873/cgp.20133. PMID: 31243109Free PMC Article
Current understanding and management of nasopharyngeal carcinoma.
Yoshizaki T, Ito M, Murono S, Wakisaka N, Kondo S, Endo K
Auris Nasus Larynx 2012 Apr;39(2):137-44. Epub 2011 May 17 doi: 10.1016/j.anl.2011.02.012. PMID: 21592702

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

Whole-Exome Sequencing Study of Familial Nasopharyngeal Carcinoma and Its Implication for Identifying High-Risk Individuals.
Wang TM, He YQ, Xue WQ, Zhang JB, Xia YF, Deng CM, Zhang WL, Xiao RW, Liao Y, Yang DW, Zhou T, Li DH, Luo LT, Tong XT, Wu YX, Chen XY, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Wang F, Wu ZY, Zheng MQ, Huang JW, Jia YJ, Yuan LL, You R, Zhou GQ, Lu LX, Liu YY, Chen MY, Feng L, Dai W, Ren ZF, Mai HQ, Sun Y, Ma J, Zheng W, Lung ML, Jia WH
J Natl Cancer Inst 2022 Dec 8;114(12):1689-1697. doi: 10.1093/jnci/djac177. PMID: 36066420
A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma.
Sun N, Wang XQ
Eur Rev Med Pharmacol Sci 2019 Jul;23(13):5770-5778. doi: 10.26355/eurrev_201907_18315. PMID: 31298328
Genetic susceptibility to the endemic form of NPC.
Bei JX, Zuo XY, Liu WS, Guo YM, Zeng YX
Chin Clin Oncol 2016 Apr;5(2):15. doi: 10.21037/cco.2016.03.11. PMID: 27121875
The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma.
Yang H, Yu K, Zhang R, Li J, Wei X, Zhang Y, Zhang C, Xiao F, Zhao D, Lin X, Wu H, Yang X
Tumour Biol 2016 Jun;37(6):7119-28. Epub 2016 Apr 8 doi: 10.1007/s13277-016-5051-9. PMID: 27059731

Diagnosis

A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
PP2A and tumor radiotherapy.
Lei X, Ma N, Du L, Liang Y, Zhang P, Han Y, Qu B
Hereditas 2020 Aug 26;157(1):36. doi: 10.1186/s41065-020-00149-7. PMID: 32847617Free PMC Article
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
Wang L, Yang J, Peng SY, Li GQ, Tu ZW
Cancer Radiother 2020 Apr;24(2):93-98. Epub 2020 Feb 11 doi: 10.1016/j.canrad.2019.09.008. PMID: 32057645
Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma.
Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y, Chen G, Huang QH, Xie SH, Cao SM, Shao JY, Jia WH, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Huang G, Zeng Y, Zeng YX, Adami HO, Ye W
Am J Epidemiol 2018 Oct 1;187(10):2117-2125. doi: 10.1093/aje/kwy095. PMID: 29701753Free PMC Article
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Therapy

A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
Wang L, Yang J, Peng SY, Li GQ, Tu ZW
Cancer Radiother 2020 Apr;24(2):93-98. Epub 2020 Feb 11 doi: 10.1016/j.canrad.2019.09.008. PMID: 32057645
Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma.
Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y, Chen G, Huang QH, Xie SH, Cao SM, Shao JY, Jia WH, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Huang G, Zeng Y, Zeng YX, Adami HO, Ye W
Am J Epidemiol 2018 Oct 1;187(10):2117-2125. doi: 10.1093/aje/kwy095. PMID: 29701753Free PMC Article
Quantitative assessment of the association between interleukin-10 promoter gene polymorphisms and nasopharyngeal carcinoma susceptibility.
Huang H, Wu Y, Liao D, Zhang H
Minerva Med 2016 Apr;107(2):92-100. Epub 2016 Feb 3 PMID: 26842763
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Prognosis

Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma.
Sun N, Wang XQ
Eur Rev Med Pharmacol Sci 2019 Jul;23(13):5770-5778. doi: 10.26355/eurrev_201907_18315. PMID: 31298328
A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility.
Ma L, Li S, Lu Y, Zhang X, Zhao J, Qin X
Eur Arch Otorhinolaryngol 2016 Apr;273(4):819-25. Epub 2014 Dec 31 doi: 10.1007/s00405-014-3465-9. PMID: 25547230
Targeting Jab1/CSN5 in nasopharyngeal carcinoma.
Pan Y, Claret FX
Cancer Lett 2012 Dec 30;326(2):155-60. Epub 2012 Aug 4 doi: 10.1016/j.canlet.2012.07.033. PMID: 22867945Free PMC Article
Unlocking the Rosetta Stone enigma for nasopharyngeal carcinoma: genetics, viral infection, and epidemiological factors.
Lung ML
Semin Cancer Biol 2012 Apr;22(2):77-8. Epub 2012 Jan 14 doi: 10.1016/j.semcancer.2012.01.006. PMID: 22266061
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Clinical prediction guides

Whole-Exome Sequencing Study of Familial Nasopharyngeal Carcinoma and Its Implication for Identifying High-Risk Individuals.
Wang TM, He YQ, Xue WQ, Zhang JB, Xia YF, Deng CM, Zhang WL, Xiao RW, Liao Y, Yang DW, Zhou T, Li DH, Luo LT, Tong XT, Wu YX, Chen XY, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Wang F, Wu ZY, Zheng MQ, Huang JW, Jia YJ, Yuan LL, You R, Zhou GQ, Lu LX, Liu YY, Chen MY, Feng L, Dai W, Ren ZF, Mai HQ, Sun Y, Ma J, Zheng W, Lung ML, Jia WH
J Natl Cancer Inst 2022 Dec 8;114(12):1689-1697. doi: 10.1093/jnci/djac177. PMID: 36066420
Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma.
Viet NH, Trung NQ, Dong LT, Trung LQ, Espinoza JL
J Cancer Res Clin Oncol 2021 Mar;147(3):713-723. Epub 2021 Jan 3 doi: 10.1007/s00432-020-03475-5. PMID: 33392659
Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma.
Sun N, Wang XQ
Eur Rev Med Pharmacol Sci 2019 Jul;23(13):5770-5778. doi: 10.26355/eurrev_201907_18315. PMID: 31298328
CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Yao K, Qin H, Gong L, Zhang R, Li L
Eur Arch Otorhinolaryngol 2017 Jan;274(1):253-259. Epub 2016 Aug 4 doi: 10.1007/s00405-016-4236-6. PMID: 27491320
Quantitative assessment of the association between interleukin-10 promoter gene polymorphisms and nasopharyngeal carcinoma susceptibility.
Huang H, Wu Y, Liao D, Zhang H
Minerva Med 2016 Apr;107(2):92-100. Epub 2016 Feb 3 PMID: 26842763

Recent systematic reviews

The Epstein-Barr virus latent membrane protein-1 (LMP1) 30-bp deletion and XhoI-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies.
da Costa VG, Marques-Silva AC, Moreli ML
Syst Rev 2015 Apr 13;4:46. doi: 10.1186/s13643-015-0037-z. PMID: 25927427Free PMC Article
Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review.
Jia WH, Qin HD
Semin Cancer Biol 2012 Apr;22(2):117-26. Epub 2012 Jan 30 doi: 10.1016/j.semcancer.2012.01.009. PMID: 22311401

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