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Family history of sudden cardiac death

MedGen UID:
414193
•Concept ID:
C2825161
•
Finding
Synonym: History of Sudden Cardiac Death
SNOMED CT: Family history of sudden cardiac death (117361000119104)

Definition

A first-degree relative (parent, sibling, child) documented to have died suddenly of presumed cardiac etiology without other obvious cause. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Family history of sudden cardiac death

Professional guidelines

PubMed

Brugada syndrome - minimizing overdiagnosis and over treatment in children.
Corcia MCG
Curr Opin Cardiol 2022 Jan 1;37(1):80-85. doi: 10.1097/HCO.0000000000000941. PMID: 34654031
Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy.
Bos JM, Will ML, Gersh BJ, Kruisselbrink TM, Ommen SR, Ackerman MJ
Mayo Clin Proc 2014 Jun;89(6):727-37. Epub 2014 May 1 doi: 10.1016/j.mayocp.2014.01.025. PMID: 24793961Free PMC Article
Evaluation and management of heart murmurs in children.
Frank JE, Jacobe KM
Am Fam Physician 2011 Oct 1;84(7):793-800. PMID: 22010618

Recent clinical studies

Etiology

Brugada Syndrome.
Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC
JACC Clin Electrophysiol 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001. PMID: 35331438
CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.
Galić E, Bešlić P, Kilić P, Planinić Z, Pašalić A, Galić I, Ćubela VV, Pekić P
Acta Clin Croat 2021 Dec;60(4):739-748. doi: 10.20471/acc.2021.60.04.22. PMID: 35734489Free PMC Article
Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence.
Shah SR, Park K, Alweis R
Curr Probl Cardiol 2019 Mar;44(3):92-106. Epub 2018 May 10 doi: 10.1016/j.cpcardiol.2018.04.002. PMID: 29784533
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).
Authors/Task Force members, Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins H
Eur Heart J 2014 Oct 14;35(39):2733-79. Epub 2014 Aug 29 doi: 10.1093/eurheartj/ehu284. PMID: 25173338

Diagnosis

Brugada Syndrome.
Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC
JACC Clin Electrophysiol 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001. PMID: 35331438
CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.
Galić E, Bešlić P, Kilić P, Planinić Z, Pašalić A, Galić I, Ćubela VV, Pekić P
Acta Clin Croat 2021 Dec;60(4):739-748. doi: 10.20471/acc.2021.60.04.22. PMID: 35734489Free PMC Article
Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence.
Shah SR, Park K, Alweis R
Curr Probl Cardiol 2019 Mar;44(3):92-106. Epub 2018 May 10 doi: 10.1016/j.cpcardiol.2018.04.002. PMID: 29784533
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).
Authors/Task Force members, Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins H
Eur Heart J 2014 Oct 14;35(39):2733-79. Epub 2014 Aug 29 doi: 10.1093/eurheartj/ehu284. PMID: 25173338

Therapy

Brugada Syndrome.
Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC
JACC Clin Electrophysiol 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001. PMID: 35331438
CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.
Galić E, Bešlić P, Kilić P, Planinić Z, Pašalić A, Galić I, Ćubela VV, Pekić P
Acta Clin Croat 2021 Dec;60(4):739-748. doi: 10.20471/acc.2021.60.04.22. PMID: 35734489Free PMC Article
Variant Angina and Aborted Sudden Cardiac Death.
Kundu A, Vaze A, Sardar P, Nagy A, Aronow WS, Botkin NF
Curr Cardiol Rep 2018 Mar 8;20(4):26. doi: 10.1007/s11886-018-0963-1. PMID: 29520510
The story of … a lead.
Nisam S, Reddy S
Europace 2015 May;17(5):677-88. Epub 2015 Mar 8 doi: 10.1093/europace/euu391. PMID: 25755290
Short QT syndrome.
Schimpf R, Wolpert C, Gaita F, Giustetto C, Borggrefe M
Cardiovasc Res 2005 Aug 15;67(3):357-66. doi: 10.1016/j.cardiores.2005.03.026. PMID: 15890322

Prognosis

Brugada Syndrome.
Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC
JACC Clin Electrophysiol 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001. PMID: 35331438
Yield of Clinical Screening for Hypertrophic Cardiomyopathy in Child First-Degree Relatives.
Norrish G, Jager J, Field E, Quinn E, Fell H, Lord E, Cicerchia MN, Ochoa JP, Cervi E, Elliott PM, Kaski JP
Circulation 2019 Jul 16;140(3):184-192. Epub 2019 Apr 22 doi: 10.1161/CIRCULATIONAHA.118.038846. PMID: 31006259Free PMC Article
Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy.
van Waning JI, Caliskan K, Hoedemaekers YM, van Spaendonck-Zwarts KY, Baas AF, Boekholdt SM, van Melle JP, Teske AJ, Asselbergs FW, Backx APCM, du Marchie Sarvaas GJ, Dalinghaus M, Breur JMPJ, Linschoten MPM, Verlooij LA, Kardys I, Dooijes D, Lekanne Deprez RH, IJpma AS, van den Berg MP, Hofstra RMW, van Slegtenhorst MA, Jongbloed JDH, Majoor-Krakauer D
J Am Coll Cardiol 2018 Feb 20;71(7):711-722. doi: 10.1016/j.jacc.2017.12.019. PMID: 29447731
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article
Novel genotype-phenotype associations demonstrated by high-throughput sequencing in patients with hypertrophic cardiomyopathy.
Lopes LR, Syrris P, Guttmann OP, O'Mahony C, Tang HC, Dalageorgou C, Jenkins S, Hubank M, Monserrat L, McKenna WJ, Plagnol V, Elliott PM
Heart 2015 Feb;101(4):294-301. Epub 2014 Oct 28 doi: 10.1136/heartjnl-2014-306387. PMID: 25351510Free PMC Article

Clinical prediction guides

CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.
Galić E, Bešlić P, Kilić P, Planinić Z, Pašalić A, Galić I, Ćubela VV, Pekić P
Acta Clin Croat 2021 Dec;60(4):739-748. doi: 10.20471/acc.2021.60.04.22. PMID: 35734489Free PMC Article
Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy.
van Waning JI, Caliskan K, Hoedemaekers YM, van Spaendonck-Zwarts KY, Baas AF, Boekholdt SM, van Melle JP, Teske AJ, Asselbergs FW, Backx APCM, du Marchie Sarvaas GJ, Dalinghaus M, Breur JMPJ, Linschoten MPM, Verlooij LA, Kardys I, Dooijes D, Lekanne Deprez RH, IJpma AS, van den Berg MP, Hofstra RMW, van Slegtenhorst MA, Jongbloed JDH, Majoor-Krakauer D
J Am Coll Cardiol 2018 Feb 20;71(7):711-722. doi: 10.1016/j.jacc.2017.12.019. PMID: 29447731
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article
Novel genotype-phenotype associations demonstrated by high-throughput sequencing in patients with hypertrophic cardiomyopathy.
Lopes LR, Syrris P, Guttmann OP, O'Mahony C, Tang HC, Dalageorgou C, Jenkins S, Hubank M, Monserrat L, McKenna WJ, Plagnol V, Elliott PM
Heart 2015 Feb;101(4):294-301. Epub 2014 Oct 28 doi: 10.1136/heartjnl-2014-306387. PMID: 25351510Free PMC Article
A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD).
O'Mahony C, Jichi F, Pavlou M, Monserrat L, Anastasakis A, Rapezzi C, Biagini E, Gimeno JR, Limongelli G, McKenna WJ, Omar RZ, Elliott PM; Hypertrophic Cardiomyopathy Outcomes Investigators
Eur Heart J 2014 Aug 7;35(30):2010-20. Epub 2013 Oct 14 doi: 10.1093/eurheartj/eht439. PMID: 24126876

Recent systematic reviews

CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.
Galić E, Bešlić P, Kilić P, Planinić Z, Pašalić A, Galić I, Ćubela VV, Pekić P
Acta Clin Croat 2021 Dec;60(4):739-748. doi: 10.20471/acc.2021.60.04.22. PMID: 35734489Free PMC Article
Does the Age of Sudden Cardiac Death in Family Members Matter in Brugada Syndrome?
Rattanawong P, Kewcharoen J, Kanitsoraphan C, Barry T, Shanbhag A, Ko Ko NL, Vutthikraivit W, Home M, Agasthi P, Ashraf H, Shimizu W, Shen WK
J Am Heart Assoc 2021 Jun;10(11):e019788. Epub 2021 May 20 doi: 10.1161/JAHA.120.019788. PMID: 34013737Free PMC Article
Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis.
Norrish G, Cantarutti N, Pissaridou E, Ridout DA, Limongelli G, Elliott PM, Kaski JP
Eur J Prev Cardiol 2017 Jul;24(11):1220-1230. Epub 2017 May 9 doi: 10.1177/2047487317702519. PMID: 28482693
A systematic review and meta-analysis of genotype-phenotype associations in patients with hypertrophic cardiomyopathy caused by sarcomeric protein mutations.
Lopes LR, Rahman MS, Elliott PM
Heart 2013 Dec;99(24):1800-11. Epub 2013 May 14 doi: 10.1136/heartjnl-2013-303939. PMID: 23674365
Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: systematic review of clinical risk markers.
Christiaans I, van Engelen K, van Langen IM, Birnie E, Bonsel GJ, Elliott PM, Wilde AA
Europace 2010 Mar;12(3):313-21. Epub 2010 Jan 29 doi: 10.1093/europace/eup431. PMID: 20118111

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